James' World 2

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People often think they know what causes chronic depression. Surveys indicate that more than 80% of the public blames a “chemical imbalance” in the brain. That idea is widespread in pop psychology and cited in research papers and medical textbooks. Listening to Prozac, a book that describes the life-changing value of treating depression with medications that aim to correct this imbalance, spent months on the New York Times bestseller list.

The unbalanced brain chemical in question is serotonin, an important neurotransmitter with fabled “feel-good” effects. Serotonin helps regulate systems in the brain that control everything from body temperature and sleep to sex drive and hunger. For decades, it has also been touted as the pharmaceutical MVP for fighting depression. Widely prescribed medications like Prozac (fluoxetine) are designed to treat chronic depression by raising serotonin levels.

Yet the causes of depression go far beyond serotonin deficiency. Clinical studies have repeatedly concluded that the role of serotonin in depression has been overstated. Indeed, the entire premise of the chemical-imbalance theory may be wrong, despite the relief that Prozac seems to bring to many patients.

A literature review that appeared in Molecular Psychiatry in July was the latest and perhaps loudest death knell for the serotonin hypothesis, at least in its simplest form. An international team of scientists led by Joanna Moncrieff of University College London screened 361 papers from six areas of research and carefully evaluated 17 of them. They found no convincing evidence that lower levels of serotonin caused or were even associated with depression. People with depression didn’t reliably seem to have less serotonin activity than people without the disorder. Experiments in which researchers artificially lowered the serotonin levels of volunteers didn’t consistently cause depression. Genetic studies also seemed to rule out any connection between genes affecting serotonin levels and depression, even when the researchers tried to consider stress as a possible cofactor.

“If you were still of the opinion that it was simply a chemical imbalance of serotonin, then yeah, it’s pretty damning,” said Taylor Braund, a clinical neuroscientist and postdoctoral research fellow at the Black Dog Institute in Australia who was not involved in the new study. (“The black dog” was Winston Churchill’s term for his own dark moods, which some historians speculate were depression.)

The realization that serotonin deficits by themselves probably don’t cause depression has left scientists wondering what does. The evidence suggests that there may not be a simple answer. In fact, it’s leading neuropsychiatric researchers to rethink what depression might be.

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Harol Bustos for Quanta Magazine

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If you’re looking to improve your sleep quality, there are a few basic changes you can make to both your workday and your bedtime routines. But your sleep environment matters, too. In fact, many people’s bedrooms aren’t designed well to maximize their sleep quality–and often wind up harming it.

One way to improve your sleeping arrangement is simply to approach it from four of your five senses (everything minus taste). Here’s how, in order of importance.

1. Sight

Light directly impacts your ability to sleep, so if you only make one change to your bedroom setup, commit to addressing light-related issues above all else.

There’s a spectrum of frequencies within all the light we see (as well as the light we don’t see), called wavelengths, and it’s within the range of 450–480 nanometers, which we call “blue light,” that’s worth looking out for. When exposed to the eye, this blue range causes the eye’s “melinopsin” (a photopigment) cells to signal the brain to turn off the melatonin, the chemical that tells your body it’s time for bed. This isn’t good when you’re trying to fall asleep. Bedside table lamps, TVs, phones, tablets, and laptops all emanate those blue-light wavelengths.

So while darker is generally better, filtered light is also better. Here are some products and techniques for eliminating blue light:

• Blackout shades. Yes, these do work, and they work well. If your bedroom faces east, you may be getting a lot of sunlight in the morning, which can cut into the last leg of your sleep cycle. If you try blackout shades, avoid just hanging a liner behind your ordinary drapes. You’re better off with a product that has two to three layers to really block out light (as a bonus, these tend to keep your room cool–which matters, too, as I’ll explain below).

• Specially filtered light bulbs. These are now commercially available (online and at many hardware and lighting stores) and priced around $20 or so, designed with a built-in filter to reduce blue light.

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Photo by nadia_bormotova/Getty Images.

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What is the most uninformative statement that people are inclined to make? My nominee would be “I love to travel.” This tells you very little about a person, because nearly everyone likes to travel; and yet people say it, because, for some reason, they pride themselves both on having travelled and on the fact that they look forward to doing so.

The opposition team is small but articulate. G. K. Chesterton wrote that “travel narrows the mind.” Ralph Waldo Emerson called travel “a fool’s paradise.” Socrates and Immanuel Kant—arguably the two greatest philosophers of all time—voted with their feet, rarely leaving their respective home towns of Athens and Königsberg. But the greatest hater of travel, ever, was the Portuguese writer Fernando Pessoa, whose wonderful “Book of Disquiet” crackles with outrage:

If you are inclined to dismiss this as contrarian posturing, try shifting the object of your thought from your own travel to that of others. At home or abroad, one tends to avoid “touristy” activities. “Tourism” is what we call travelling when other people are doing it. And, although people like to talk about their travels, few of us like to listen to them. Such talk resembles academic writing and reports of dreams: forms of communication driven more by the needs of the producer than the consumer.

One common argument for travel is that it lifts us into an enlightened state, educating us about the world and connecting us to its denizens. Even Samuel Johnson, a skeptic—“What I gained by being in France was, learning to be better satisfied with my own country,” he once said—conceded that travel had a certain cachet. Advising his beloved Boswell, Johnson recommended a trip to China, for the sake of Boswell’s children: “There would be a luster reflected upon them. . . . They would be at all times regarded as the children of a man who had gone to view the wall of China.”

Travel gets branded as an achievement: see interesting places, have interesting experiences, become interesting people. Is that what it really is?

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Illustration by María Medem

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Travelling-induced jet lag isn’t the only thing that causes untimely fatigue. Ignoring your biological rhythms can lead to chronic exhaustion, too, something that feels so much like jet lag that Till Roenneberg and his team, at Ludwig-Maximilian University, in Munich, Germany, coined the term “social jet lag” in 2006. It occurs when there’s a mismatch between your biological clock and your social life. And not only does it make you tired, it may be to blame for many of today’s ailments. In 2012, Roenneberg and colleagues studied the sleep-wake patterns of more than 65,000 people. They found that 80 percent of those who had jobs also used an alarm clock. The problem with

that, chronobiologists say, is that our own bodies’ clocks are far better for telling us when to wake up.

Unlike the rigid global clock, whose time zones are an artifice of our connected world, our internal clocks vary from person to person, and even within individuals as they move from childhood into puberty, adolescence, and adulthood. The discrepancy between our internal, biological clocks and our external, social clocks peaks around age 20. But the ongoing tug-of-war between external and internal time can affect everyone from school-aged children—whose schedules are dictated by their school districts—to those of retirement age and beyond. People stay up late, or sometimes not; use alarms to wake up early, or snooze it to sleep in; and then spend weekend mornings trying to make up for the sleep they missed, or they don’t. The result? A massive sleep debt and an off-kilter internal clock.

Each of us has a circadian clock that uses a roughly 24-hour rhythm that coordinates with the Earth’s light-dark cycle. Light-sensitive cells in the eye’s retina send information to the brain’s master clock, which readjusts daily. The master clock regulates systemic cues like body temperature, eating patterns, and even fluctuating hormone levels, which are then used by distant, peripheral cellular clocks throughout the body to fine-tune their respective molecular pathways so as to be in synchrony with the master clock phase. The resulting, cyclical patterns can be seen in everything from our behavior to our blood-sugar levels. And when the coordination persistently goes awry, the phase difference between the master and peripheral clocks can manifest as chronic, degenerative diseases. 

Initially, scientists thought these broken circadian clocks were most concerning in night-shift workers, flight attendants, and frequent flyers—people whose jobs resulted in large and regular disruptions to their sleep-wake timing. But research seems to be revealing that, to some degree, all of us are being affected.

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Photo from Atlantis Images/Shutterstock.

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The digital renderings of North Bayshore, a massive proposed development in Mountain View, California, are crowded with glistening buildings and cheerful, animated pedestrians. There’s a lot to show off, including 7,000 new homes, three distinct neighborhoods, and nearly 300,000 square feet of retail and community space. Notably, though, the gleaming images don’t bear any hints of the company behind the whole endeavor: Google.

Companies like Google and Facebook’s parent, Meta, conquered the digital realm a long time ago, setting the ground rules for how we search, interact, and shop online. Not content to stop there, however, these firms are now making huge bids to expand their reach. They want to be landlords, too.

Across the country, corporations are using their considerable sway and resources to build modern company towns — mini-cities that will feature all the trappings of traditional civic life, including housing, shops, and public spaces. These new projects won’t have corporate logos on every building, and many of the units will be available to the general public, not just employees. But in the grand scheme of real estate, they’re distinct: After years of running up against housing shortages in their backyards, companies like Google, Meta, and Disney — not exactly known for building new homes — are taking matters into their own hands. Their creations have boring names like Middlefield Park and Willow Village, but they might as well be called Zucktown or Google City, USA. And while the developments promise thousands of new homes, the plans are also a tacit acknowledgment of the bleak state of the American housing market and the roles these companies have played in driving up home prices near their sprawling HQs.

The companies behind these projects argue that they can help solve the country’s lack of affordable housing, but it’s fair to approach the plans with a healthy degree of skepticism. America’s single-employer “company towns” have a long, bloody history of exploitation and labor strife. While the current plans hardly represent a return to those dark days of the 19th and early-20th centuries, they probably won’t usher in a new era of futuristic techno-utopias, either. Judging by the plans that have been publicly unveiled so far, the Googles and Metas of the world aren’t aiming nearly that high. Instead, their visions of city living spaces look a lot like what we’re already used to seeing from modern real-estate developers: glassy office buildings, verdant parks, and walkable main streets with coffee shops, salad bars, and alluring apartment buildings. It’s nice, but not exactly groundbreaking stuff.

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About a month after the Civil War began, a slaveholding ancestor of current U.S. Congressman French Hill seemed confident about the future. “Lincoln can’t starve me out unless he takes my land and negros,” plantation owner Creed Taylor wrote to a relative.

By the time the war ended in 1865, President Abraham Lincoln had freed the enslaved, including at least 70 who worked Taylor’s cotton fields here. But Taylor’s family found a path back to prosperity that didn’t look much different from the way he had first made his fortune.

Taylor still owned at least 1,500 acres of farmland. By the turn of the 20th century, his grandson oversaw a sprawling cotton operation that would eventually grow to more than 10 times the size of Taylor’s farm. And for years, the fields would be worked once again by Black people who didn’t have a choice.

Emancipation dealt many slaveholders a staggering economic blow, wiping out vast amounts of wealth across the South. In 1870, five years after the war ended and about 4 million Black people were freed from slavery, the states that once made up the Confederacy were enduring one of the largest wealth shocks in American history. The reported wealth of Southerners dropped by $4.3 billion, or about 65%, from a decade earlier, a Reuters analysis found. Put another way, war and emancipation appear to have erased about two-thirds of wealth in the South.

Those who lost the most, like Congressman Hill’s direct ancestor, were the largest enslavers. They also had the clearest path to rebuilding – often by replicating elements of the slavery economy and reinstituting feudal systems that embraced white supremacy.

The Black people who had been enslaved emerged with far less. Racial violence and voting laws locked them out of political power. Schooling was limited, leaving most unable to read and write. The federal government let former slaveholders keep their land, and the newly freed were afforded few paths to prosper – leaving them once again at the mercy of the white elite. tangie

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The forebears of three members of Congress regained – and passed forward – wealth and power their families lost when slavery was abolished. Their success shows how the Southern elite exploited Black Americans in new ways.

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This past Thanksgiving, I asked my mother how old she was in her head. She didn’t pause, didn’t look up, didn’t even ask me to repeat the question, which would have been natural, given that it was both syntactically awkward and a little odd. We were in my brother’s dining room, setting the table. My mother folded another napkin. “Forty-five,” she said.

She is 76.

Why do so many people have an immediate, intuitive grasp of this highly abstract concept—“subjective age,” it’s called—when randomly presented with it? It’s bizarre, if you think about it. Certainly, most of us don’t believe ourselves to be shorter or taller than we actually are. We don’t think of ourselves as having smaller ears or longer noses or curlier hair. Most of us also know where our bodies are in space, what physiologists call “proprioception.”

Yet, we seem to have an awfully rough go of locating ourselves in time. A friend, nearing 60, recently told me that whenever he looks in the mirror, he’s not so much unhappy with his appearance as startled by it—“as if there’s been some sort of error” were his exact words. (High-school reunions can have this same confusing effect. You look around at your lined and thickened

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