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A Biochemist’s View of Life’s Origin Reframes Cancer and Aging

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All living cells power themselves by coaxing energetic electrons from one side of a membrane to the other. Membrane-based mechanisms for accomplishing this are, in a sense, as universal a feature of life as the genetic code. But unlike the genetic code, these mechanisms are not the same everywhere: The two simplest categories of cells, bacteria, and archaea have membranes and protein complexes for producing energy that are chemically and structurally dissimilar. Those differences make it hard to guess how the very first cells met their energy needs.

This mystery led Nick Lane, a professor of evolutionary biochemistry at University College London, to an unorthodox hypothesis about the origin of life. What if life arose in a geological environment where electrochemical gradients across tiny barriers occurred naturally, supporting a primitive form of metabolism while cells as we know them evolved? A place where this might be possible suggested itself: alkaline hydrothermal vents on the deep seafloor, inside highly porous rock formations that are almost like mineralized sponges.

Lane has explored this provocative idea in a variety of journal papers, and he has touched on it in some of his books, such as The Vital Question, where he wrote, “Carbon and energy metabolism are driven by proton gradients, exactly what the vents provided for free.” He describes the idea in more detail for the general public in his latest book, Transformer: The Deep Chemistry of Life and Death. In his view, metabolism is central to life, and genetic information emerges naturally from it rather than the other way around. Lane believes that the implications of this reversal touch almost every big mystery in biology, including the nature of cancer and aging.

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https://d2r55xnwy6nx47.cloudfront.net/uploads/2050/08/Nick_Lane_2880x1620_Lede-scaled.jpgIn contrast to many other researchers who study the origin of life, Nick Lane, a professor of evolutionary biochemistry at University College London, suggests that some form of primitive metabolism may have arisen in deep-sea hydrothermal vents before the appearance of genetic information.  Philipp Ammon for Quanta Magazine

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A Biochemist’s View of Life’s Origin Reframes Cancer and Aging

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Cosmologist Laura Mersini-Houghton: ‘Our universe is one tiny grain of dust in a beautiful cosmos’

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Ethiopia’s Capital

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Addis Ababa is the capital and largest city of Ethiopia. It also serves as the seat of the government of Oromia: while being outside of Oromia regional state boundaries. In the 2007 census, the city’s population was estimated to be 2,739,551 inhabitants. Addis Ababa is a highly developed and important cultural, artistic, financial, and administrative center of Ethiopia.

In the 15th century, Addis Ababa was depicted as a fortified place named “Barara” and served as a residence of the Emperors of Ethiopia until Dawit II. Barara was completely destroyed during the Ethiopian–Adal War and Oromo expansions. The founding history of Addis Ababa dates back in late 19th-century by Menelik II, Negus of Shewa, in 1886 after finding Mount Entoto unpleasant two years prior. At the time, the city was a resort town; its large mineral spring abundance attracted nobilities of the empire, led them to establish permanent settlement. It also attracted many members of the working classes — including artisans and merchants — and foreign visitors. Menelik II then formed his imperial palace in 1887. Addis Ababa became the empire’s capital in 1889, and subsequently, international embassies were opened. Addis Ababa urban development began at the beginning of the 20th century and without any preplanning.

Addis Ababa saw a wide-scale economic boom in 1926 and 1927, and an increase in the number of buildings owned by the middle class, including stone houses filled with imported European furniture. The middle class also imported newly manufactured automobiles and expanded banking institutions. During the Italian occupation, urbanization and modernization steadily increased by a master plan which they hoped Addis Ababa would be more colonial city and continued after their occupation. Consequent master plans were designed by French and British consultants from 1940s onwards focusing on monumental structures, satellite cities, and inner-city. Similarly, the Italo-Ethiopian master plan also projected in 1986 concerning only urban structure and accommodating service, which was later adapted by the 2003 master plan.

Addis Ababa remains federal chartered city in accordance with the Addis Ababa City Government Charter Proclamation No. 87/1997 in the FDRE Constitution. Referred to as “the political capital of Africa” due to its historical, diplomatic, and political significance for the continent, Addis Ababa serves as the headquarters of major international organizations such as the African Union and the United Nations Economic Commission for Africa (ECA).

The city lies a few kilometers west of the East African Rift, which splits Ethiopia into two, between the Nubian Plate and the Somali Plate. The city is surrounded by the Special Zone of Oromia and is populated by people from the different regions of Ethiopia. It is home to Addis Ababa University. The city has a high human development index and is known for its vibrant culture, strong fashion scene, high involvement of young people, thriving arts scene, and for having the fastest economic growth of any country in the world.

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An image from Ethiopia’s Capital

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We exist. What can that fact teach us about the Universe?

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For thousands of years, humans have pondered the meaning of our existence. From philosophers who debated whether their minds could be trusted to provide accurate interpretations of our reality to physicists who’ve attempted to interpret the weirder aspects of quantum physics and relativity, we’ve learned that some aspects of our Universe appear to be objectively true for everyone, while others are dependent on the actions and properties of the observer.

Although the scientific process, combined with our experiments and observations, have uncovered many of the fundamental physical laws and entities that govern our Universe, there’s still much that remains unknown. However, just as Descartes was able to reason, “I think, therefore I am,” the fact of our existence — the fact that “we are” — has inevitable physical consequences for the Universe as well. Here’s what the simple fact that we exist can teach us about the nature of our reality.

To start with, the Universe has a set of governing rules, and we’ve been able to make some sense of at least some of them. We understand how gravity works at a continuous, non-quantum level: by matter and energy curving spacetime and by that curved spacetime dictating how matter and energy move through it. We know a large portion of the particles that exist (from the Standard Model) and how they interact through the three other fundamental forces, including at the quantum level. And we know that we exist, composed of those very same particles and obeying those same laws of nature.

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https://bigthink.com/wp-content/uploads/2022/08/astrobio_award_0.jpg?lb=985,554That the Universe exists and that we are here to observe it tells us a lot. It enables us to place constraints on various parameters, and to the infer the existence of states and reactions that present themselves as gaps in our present-day knowledge. But there are severe limits to what we can learn from this type of reasoning as well  (Credit: NASA/NEXSS collaboration)

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https://bigthink.com/starts-with-a-bang/we-exist/?utm_source=pocket_discover_science

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Emotionally Intelligent People Use 5 Simple Rules to Make More Friends and Build Stronger Relationships

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How do I make more friends?

In a world where the word friend is associated by most people with superficial relationships formed on social media, true friendship is hard to come by. True friends are those who are there for you in good times and bad, who tell you what you need to hear, not just what you want to hear, and who help you be the best version of yourself–all of which can prove invaluable to entrepreneurs and business owners.

So, actually, you don’t necessarily want more friends. Rather, you want “true” friends. But to have true friends, you first need to be a friend.

But to have true friends, you first need to be a friend. How do you do that?

Emotional intelligence can help. Emotional intelligence is the ability to identify, understand, and manage emotions. This ability can help you not only understand others better but also strengthen your relationships with them.

Here are five simple rules of emotional intelligence that will help you make more and better friends, which can help you in business and life. (If you find value in these five rules, you might be interested in my free seven-day course, which delivers a rule to your inbox each day to teach you how to build emotional intelligence in yourself and your team.)

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https://img-cdn.inc.com/image/upload/w_1920,h_1080,c_fill/images/panoramic/getty_1191117019_ik7mlx.jpg

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https://www.inc.com/justin-bariso/emotional-intelligence-how-to-make-friends.html?utm_source=pocket_discover_self-improvement

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Missed News 008A

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News You might have missed!

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NEWS TED TALKS +
Pint? Anyone? The big problem men have with keeping friends How diversity makes teams more innovative | Rocío Lorenzo
12 habits of the calmest people I know | by Alex Mathers How Great Leaders Innovate Responsibly | Ken Chenault
Your Daily AM Roundup Bandits are losing interest in robbing banks, as some crimes no longer pay
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Heather Moorland

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Moorland or moor is a type of habitat found in upland areas in temperate grasslands, savannas, and shrublands and montane grasslands and shrublands biomes, characterised by low-growing vegetation on acidic soils. Moorland, nowadays, generally means uncultivated hill land (such as Dartmoor in South West England), but also includes low-lying wetlands (such as Sedgemoor, also South West England). It is closely related to heath, although experts disagree on what precisely distinguishes these types of vegetation. Generally, moor refers to highland and high rainfall zones, whereas heath refers to lowland zones which are more likely to be the result of human activity. Moorland habitats mostly occur in tropical Africa, northern and western Europe, and neotropical South America. Most of the world’s moorlands are diverse ecosystems. In the extensive moorlands of the tropics, biodiversity can be extremely high. Moorland also bears a relationship to tundra (where the subsoil is permafrost or permanently frozen soil), appearing as the tundra and the natural tree zone. The boundary between tundra and moorland constantly shifts with climatic change.

Heathland and moorland are the most extensive areas of semi-natural vegetation in the British Isles. The eastern British moorlands are similar to heaths but are differentiated by having a covering of peat. On western moors, the peat layer may be several meters thick. Scottish “muirs” are generally heather moors, but also have extensive covering of grass, cotton grass, mosses, bracken, and under-shrubs such as crowberry, with the wetter moorland having sphagnum moss merging into bog-land.

There is uncertainty about how many moors were created by human activity. Oliver Rackham writes that pollen analysis shows that some moorland, such as in the islands and extreme north of Scotland, are clearly natural, never having had trees, whereas much of the Pennine moorland area was forested in Mesolithic times. How much the deforestation was caused by climatic changes and how much by human activity is uncertain.

A variety of distinct habitat types are found in different world regions of moorland. The wildlife and vegetation forms often lead to high endemism because of the severe soil and microclimate characteristics. An example of this is the Exmoor Pony, a rare horse breed which has adapted to the harsh conditions in England’s Exmoor.

In Europe, the associated fauna consists of bird species such as red grouse, hen harrier, merlin, golden plover, curlew, skylark, meadow pipit, whinchat, ring ouzel, and twite. Other species dominate in moorlands elsewhere. Reptiles are few due to the cooler conditions. In Europe, only the common viper is frequent, though in other regions moorlands are commonly home to dozens of reptile species. Amphibians such as frogs are well represented in moorlands. When moorland is overgrazed, woody vegetation is often lost, being replaced by coarse, unpalatable grasses and bracken, with a greatly reduced fauna.

Some hill sheep breeds, such as Scottish Blackface and the Lonk, thrive on the austere conditions of heather moors.

Burning of moorland has been practised for a number of reasons, for example, when grazing is insufficient to control growth. This is recorded in Britain in the fourteenth century. Uncontrolled burning frequently caused (and causes) problems and was forbidden by statute in 1609.[citation needed] With the rise of sheep and grouse management in the nineteenth century, it again became common practice. Heather is burnt at about 10 or 12 years old when it will regenerate easily. Left longer, the woodier stems will burn more aggressively and will hinder regrowth. Burning of moorland vegetation needs to be very carefully controlled, as the peat itself can catch fire, and this can be difficult if not impossible to extinguish. In addition, uncontrolled burning of heather can promote alternative bracken and rough grass growth, which ultimately produces poorer grazing. As a result, burning is now a controversial practice; Rackham calls it “second-best land management”.

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An image from Heather Moorland

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This Is How To Have Emotionally Intelligent Arguments: 4 Secrets

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Mark didn’t mean to cut the guy off. The man in the pickup truck honked repeatedly. Mark nodded at him: Sorry. But a few minutes later Mark accidentally cut the guy off again. And that’s when things went sideways…

The man raced his truck forward and blocked Mark’s car. With both vehicles now stopped, the guy got out. All six-foot-five and three hundred pounds of him. (If I was Mark I would have considered calling ahead to reserve one of the nicer rooms in the ICU.)

The guy started banging his fist on Mark’s door. Bellowing at him with rage. Inexplicably, Mark rolled down his window:

“Have you ever had such an awful day that you’re just hoping to meet someone who will pull out a gun, shoot you, and put you out of your misery? Are you that someone?”

The man’s jaw dropped. “What?

“Yeah, I really mean it. I don’t usually cut people off, and I never cut someone off twice. I’m just having a day where no matter what I do or who I meet—including you!—I seem to mess everything up. Are you the person who is going to mercifully put an end to it?”

The man’s demeanor changed instantly. He became calm. Reassuring.

“Hey. C’mon, man. It’ll be okay. Really! Just relax, it’ll be okay. Everyone has days like this.”

They talked for a while. Nicely. The guy got back into his truck. He waved to Mark in the rearview mirror. And drove off.

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https://bakadesuyo.com/wp-content/uploads/2022/09/arguments.jpgTrue

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Neptune and its rings shown in striking new light by Webb telescope

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Missed News 007A

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Injured Tom Brady Announces His Status For Sunday’s Game Ted Cruz admitted to colleagues that all ‘one hundred senators’ knew Trump committed an impeachable defense: report
Uvalde school district suspends police force, victims’ parents react President Biden’s Approval Rating Hits 18-Month High
Five takeaways from the Arizona Senate debate between Mark Kelly and Blake Masters Texas executes John Henry Ramirez, the inmate who asked to die holding his pastor’s hand
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