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Landmark Alzheimer’s Study Pinpoints Protein That Protects Aging Brain

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The conundrum has stumped doctors for years. Why do neurodegenerative diseases such as Alzheimer’s affect only the elderly? Why do some people live to be over 100 with normal brain functioning while others develop dementia decades earlier?

Now, a new study by Harvard scientists points to a possible answer, one that could spark further research that — ultimately — could lead to new drugs and treatments for dementia.

Researchers have found that a protein active during fetal brain development, called REST, switches back on later in life to protect aging neurons from various stresses, including the toxic effects of abnormal proteins. But in those with Alzheimer’s and mild cognitive impairment, the protein — RE1-Silencing Transcription factor — is absent from key brain regions.

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7 Foods That Reduce Your Alzheimer’s Risk

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Keep your brain healthy with these foods that can slow down—or perhaps even help prevent—the disease.

Keep Your Brain Healthy

The best thing you can do to keep your brain working the way you want it to: exercise, and eat right. “Nutrition is very, very important to brain health,” says Paul Nussbaum, Ph.D., a clinical neuropsychologist and member of scientific advisory board for the Alzheimer’s Foundation of America. “Surprisingly, the brain is made up of 60% fat—it’s the fattest part of our body—and that fat insulates the nerve tracks. Without that fat we slow down mentally,” Dr. Nussbaum says.

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