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Truck hauling ‘aggressive’ monkeys thought to carry hepatitis C, herpes and Covid overturns in Mississippi with at least one on the loose

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A truck hauling “aggressive” monkeys thought to be carrying hepatitis C, herpes, and Covid-19 has overturned in Mississippi, with at least one on the loose, according to authorities.

The truck was loaded with caged Rehsus monkeys when it crashed on Interstate 59, north of Heidelberg, on Tuesday.

It was transporting the monkeys to a testing facility in Florida, Connecticut news outlet WFSB reported.

Jasper County Sheriff Randy Johnson told local outlet WAPT that 21 monkeys were on the truck, six of whom escaped.

“The monkey that got away actually crossed interstate, went out into a wooded area,” Johnson said.

The sheriff’s department initially said in a Facebook post that the monkeys posed “potential health threats.”

“The driver of the truck told local law enforcement that the monkeys were dangerous and posed a threat to humans. We took the appropriate actions after being given that information from the person transporting the monkeys. He also stated that you had to wear PPE equipment to handle the monkeys,” the department said.

Authorities said the truck was carrying monkeys from Tulane University.

The university told The Independent that the monkeys left the Tulane National Biomedical Research Center in Covington, Louisiana, and were traveling to a non-Tulane-affiliated location.

“The primates in question belong to another entity,” the university said, adding that they were not being transported by a Tulane-affiliated service.

Tulane said in a statement on X Tuesday evening that the monkeys are not infectious.

“The primates in question belong to another entity & aren’t infectious. We’re actively collaborating with local authorities & will send a team of animal care experts to assist as needed,” the university wrote.

Tulane stressed to The Independent that the monkeys “have not been exposed to any infectious agent.”

As of Tuesday afternoon, “All but one of the escaped monkeys have been destroyed. We have been in contact with an animal disposal company to help handle the situation,” authorities said.

Mississippi Wildlife and Fisheries also responded to the scene.

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https://static.independent.co.uk/2025/10/28/21/32/Screenshot-2025-10-28-at-5-21-42-PM.jpg?quality=75&width=640&auto=webp

A truck hauling ‘aggressive’ monkeys carrying hepatitis C, herpes, and Covid has overturned in Mississippi, with several on the loose, according to authorities (Jasper County Sheriff’s Department)

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Click the link below for the complete article:

https://www.independent.co.uk/news/world/americas/truck-monkeys-mississippi-tulane-missing-b2854099.html

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Why Hurricane Melissa Could Be the Worst Storm to Ever Hit Jamaica

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As Category 5 hurricane Melissa bears down on Jamaica, it is poised to be the worst storm to ever hit the Caribbean island, surpassing the damage from Hurricane Gilbert in 1988.

Gilbert, which hit Jamaica as a Category 4 hurricane, sent 19 feet of storm surge slamming into the eastern shore of the island and brought torrential rains and destructive winds. It killed 49 people, destroyed 100,000 homes, and did $700 million in damage, according to the U.S. National Oceanic and Atmospheric Administration.

Melissa, though, is far stronger and will hit from a direction that could expose more coastline to surge. And it is slower-moving, which means Jamaica will be subjected to the storm’s onslaught—especially torrential rains—for longer.

“This is going to be a lot worse than Gilbert,” says Phil Klotzbach, a senior research scientist at Colorado State University, who studies hurricanes.

Jamaica is no stranger to storms, but it has only been hit directly by five major ones (those of Category 3 or stronger), according to the best available historical records, which go back to the late 19th century. All of those major storms were either Category 3 or Category 4—we don’t know of any in recorded history that hit the island as a Category 5.

And Melissa is in rarefied company even among already rare Category 5 storms—it is exceptionally intense for an Atlantic basin hurricane. As of Monday afternoon, its maximum sustained winds are a stunning 175 miles per hour. Gilbert’s winds topped out at 130 mph when it collided with Jamaica.

Even if Melissa weakens some before it makes landfall in Jamaica, it will still be an exceptionally strong storm, and the fact that it is hitting from the south means it is running smack into a longer coastline than Gilbert did with its eastern approach. The nation’s capital, Kingston, sits on its southern shore.

The surge from Melissa is expected to reach nine to 13 feet above ground level, but exactly where that surge will be concentrated will depend on the storm’s exact path. Even small deviations could make a big difference in where the worst winds and waves hit. The farther west Melissa drifts before making a sharp turn to the northeast, the less likely it will be that the major population areas of the eastern half of the country, such as Kingston, will see the worst of the surge.

And then there is the fact that Melissa is creeping along at a pace between 3 and 5 mph, compared with Gilbert’s more typical 12 mph. “It’s barely moving,” Klotzbach says, which means the winds, surge, and rain will last agonizingly long. In fact, “they’ve been getting rain from this storm for days now,” Klotzbach says, as the weather system has drifted south of the island. Most of Jamaica is projected to get more than a foot of rain, and a wide area is forecast to get up to 30 inches. Some spots could see up to 40 inches. That amount of rain can be catastrophic, especially in Jamaica’s hilly terrain, where it can cause flash floods and landslides.

The Jamaican government has ordered mandatory evacuations for some flood-prone areas, according to the Jamaica Observer, and utilities are planning ahead for restoration efforts once the storm passes. “A Category Four hurricane potentially going through the middle of our island could have unprecedented damage on our facilities,” said Hugh Grant, chief executive officer of the Jamaica Public Service Company (JPS), at a media briefing on Sunday, according to the Jamaica Observer. “Here at JPS, it’s likely to be a rebuild and not just a restoration.”

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A cyclist rides up to a store to seek shelter from Hurricane Melissa in Portmore, Jamaica, on October 26, 2025. Ricardo Makyn/AFP/Getty Images

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Click the link below for the complete article:

https://www.scientificamerican.com/article/why-hurricane-melissa-could-be-the-worst-storm-to-ever-hit-jamaica/?_gl=1*1yhwgbg*_up*MQ..*_ga*MTYwNjE4MTIzNS4xNzYxNjQ0NjM5*_ga_0P6ZGEWQVE*czE3NjE2NDQ2MzgkbzEkZzAkdDE3NjE2NDQ2MzgkajYwJGwwJGgw

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Live Updates: Melissa’s Core Moves Off Jamaica as Hurricane Takes Aim at Cuba

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The hurricane weakened to a Category 4 as it carved a path of destruction across Jamaica. Limited communications have left officials with only partial reports as they seek to assess the scale of the damage.

Here’s the latest.

Hurricane Melissa slowly cut a soaking and destructive path across Jamaica on Tuesday after making landfall as one of the strongest Category 5 storms on record.

The hours-long overland passage sapped some of the storm’s strength, dropping it to a Category 4 by the time it began moving off Jamaica’s north coast in the afternoon, on a churning path expected to take it to Cuba last Tuesday or early Wednesday. Forecasts of Melissa’s path after that take it toward the Bahamas later on Wednesday.

Melissa has brought heavy rainfall throughout the Caribbean since late last week. The storm did not make landfall on Haiti, but it has nevertheless dropped a significant amount of rain there, and forecasters warned that flash flooding and landslides are expected for the next day. Officials there have announced that schools will be closed on Wednesday and a workers will be asked to stay home.

Jamaica’s health care system is facing “one of its most severe crises in recent memory” after Hurricane Melissa battered the island’s hospitals and clinics, according to a memo by the local response team of the Pan American Health Organization.

The storm’s advance has unleashed flood warnings in multiple hospitals, threatening to overwhelm them and disrupt essential services.

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https://static01.nyt.com/images/2025/10/28/multimedia/28wea-melissa-aid-efforts1-mqgp/28wea-melissa-aid-efforts1-mqgp-jumbo.jpg?quality=75&auto=webpKingston, Jamaica, on Tuesday, as Hurricane Melissa approaches.Credit…Octavio Jones/Reuters

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Click the link below for the complete article:

https://www.nytimes.com/live/2025/10/28/weather/hurricane-melissa-jamaica-landfall

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Live updates: Hurricane Melissa hits Jamaica with historic 185-mph winds

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Heavy floodwaters swept across southwestern Jamaica, winds tore roofs off buildings, and boulders tumbled into roads Tuesday as Hurricane Melissa came ashore as a catastrophic Category 5 storm, tied for the strongest landfalling Atlantic hurricanes in history.

The storm landed in southwestern Jamaica near New Hope and is expected to exit around St. Ann parish in the north, forecasters said. The storm is expected to slice diagonally across the island, then head for Cuba. It has been blamed for at least seven deaths so far in the Caribbean — three in Jamaica, three in Haiti, and one in the Dominican Republic.

Landslides, fallen trees and numerous power outages were reported ahead of Melissa’s landfall, with officials in Jamaica cautioning that the cleanup and damage assessment would be slow.

“There is no infrastructure in the region that can withstand a Category 5,” Jamaican Prime Minister Andrew Holness said Monday. “The question now is the speed of recovery. That’s the challenge.”

What to know:

  • Storm threatens flooding and landslides: Melissa could cause catastrophic flash flooding and numerous landslides, the U.S. National Hurricane Center warned Monday. A life-threatening storm surge of up to 13 feet (4 meters) is expected across southern Jamaica, and massive wind damage is expected in Melissa’s core.
  • Cuba is next at risk: The storm is expected to make landfall late Tuesday or early Wednesday in eastern Cuba, where hundreds of thousands of people have prepared to evacuate. Up to 20 inches (51 centimeters) of rain are forecast in areas, with a significant storm surge along the coast. The hurricane is expected to reach the southeastern Bahamas by Wednesday evening.
  • Warming oceans fuel Melissa’s ferocity: The warming of the world’s oceans caused by climate change helped double Hurricane Melissa’s wind speed in less than 24 hours over the weekend, climate scientists said Monday. Scientists said this is the fourth storm in the Atlantic this year to undergo rapid intensification of its wind speed and power.

Evacuations already well underway in Cuba

The president of the Provincial Defense Council and first secretary of the Cuban Communist Party in the eastern province of Santiago de Cuba, Beatriz Johnson Urrutia, said that some 281,000 people have already been evacuated and taken to 101 evacuation centers in that region or are staying with neighbors or relatives.

Some low-lying or coastal communities have been completely evacuated, with only the personnel in charge of safeguarding property remaining.

Of the 16 reservoirs managed by the National Institute of Hydraulic Resources in the province, five are discharging water, with 78% of their capacity accumulated in anticipation of heavy downpours.

Blocked roads and severe flooding seen across Jamaica

Desmond McKenzie, deputy chairman of Jamaica’s Disaster Risk Management Council, noted that extensive damage was reported in the southwestern parish of St. Elizabeth, which he said “is under water.”

He said severe damage also was reported in parts of Clarendon in southern Jamaica.

Almost every parish in the country is experiencing blocked roads, fallen trees, damaged utility poles and excessive flooding, McKenzie said.

He said four main hospitals are damaged, with the storm knocking out power to one of them, forcing officials to evacuate 75 patients.

At least 3 families trapped and unable to be rescued until conditions improve, officials say

Floodwaters trapped at least three families in their homes in the community of Black River in western Jamaica, and crews were unable to help them because of dangerous weather conditions, said Desmond McKenzie, deputy chairman of Jamaica’s Disaster Risk Management Council.

“Roofs were flying off,” he said. “We are hoping and praying that the situation will ease so that some attempt can be made to get to those persons.”

McKenzie said there are no confirmed reports of deaths and stressed that it was too early to talk about the extent of the damage because the storm was still pummeling the island.

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Leaflet | Powered by Esri | USGS, NOAA

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Click the link below for the complete article:

https://apnews.com/live/hurricane-melissa-jamaica-tracking-updates?utm_source=firefox-newtab-en-us

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Trump Team Backs Unproven Autism Drug, Sparking Scientific Concern

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Hmmmm… Poor and young MAGA people have been Bamboozled by the current administration!

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According to Martin Makary, head of the US Food and Drug Administration (FDA), the drug leucovorin will help “hundreds of thousands of kids” with autism. But a day after Makary praised leucovorin’s powers at a White House event, some specialists are warning that the science to warrant Makary’s enthusiasm is far from solid.

Those researchers say that the drug’s efficacy has not been established, that scientists don’t know how much of the drug to give or how people should take it, and that safety data in children are lacking. According to the FDA’s current plans, leucovorin will be available to only a minority of autistic people.

All of this has led to widespread confusion, say clinicians, who also worry about the expectations created by Makary and other officials in the administration of US president Donald Trump.

“I’ve heard from a lot of families,” says psychologist Catherine Lord at the University of California, Los Angeles. “The major thing they say is, ‘What is this? What do we do?’”

“I don’t want to get everyone’s hopes up that this is a magic cure,” says Rebecca Schmidt, a molecular epidemiologist at the University of California, Davis. “It’s not for everybody.”

Vitamin in the spotlight

At an announcement on 22 September, Makary announced the upcoming approval of leucovorin, a form of the vitamin folate, by saying it would “open the door to the first FDA-recognized treatment pathway for autism”. People with low levels of folate in the protective fluid surrounding the brain and spine can sometimes exhibit traits associated with autism, including challenges in social communication. This condition, called cerebral folate deficiency, could be due to rogue antibodies that attack the body’s own proteins – in this case, proteins that ensure import of folate into the brain.

There have been clinical trials of leucovorin, also called folinic acid, in autism, but the studies to date have been small. For example, one recent clinical trial enrolled about 80 children aged 2 to 10, and provided folinic acid supplements to about half of the participants. Neither the participants nor their physicians knew who received the supplement and who received a placebo. Participants who received the supplement reported greater improvements in social interactions and language skills than those who received the placebo.

After the trial was published, some researchers subsequently raised concerns that the assessment of those improvements was subjective, and that the study was too small to detect subtle differences in response.

Call for bigger trials

But size is not the only thing that matters in clinical trials, says Dan Rossignol, a family physician in Aliso Viejo, California, who has studied the data on leucovorin and sometimes prescribes it to autistic children. The effect of leucovorin in the trials has been large enough to be apparent even with small numbers of participants, he says. Specifically, Rossignol points to an early leucovorin clinical study, in which only 48 children participated but some experienced marked improvements in a standardized assessment of speech.

“But it would be great if more studies were done with more kids,” he says. “Then w

e could tease out which kids respond better.” Typically, studies submitted for FDA approval of a drug for autism might have data from hundreds of children, he says, but it has been difficult to raise the money for bigger trials. Rossignol says that he and a colleague have been in discussions with US President Donald Trump’s administration to make the case for leucovorin.On Monday, the Trump administration said the US National Institutes of Health plans to monitor the effects of the FDA’s anticipated approval and to study possible broader benefits of leucovorin in autistic people. No details have been released as to how such studies will be designed.

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https://static.scientificamerican.com/dam/m/6c8a9724b33e08e0/original/folinic_acid_illustration.jpg?m=1758740921.394&w=900

Globes of folinic acid, also called leucovorin, which Trump team officials have promoted as an intervention for autism.  Alfred Pasieka/Science Source

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Click the link below for the complete article:

https://www.scientificamerican.com/article/what-is-leucovorin-the-unproven-autism-drug-backed-by-trump-officials/?_gl=1*dd7py6*_up*MQ..*_ga*MzUzNTg2MTk0LjE3NjEzODA3MDM.*_ga_0P6ZGEWQVE*czE3NjEzODA3MDIkbzEkZzAkdDE3NjEzODA3MDIkajYwJGwwJGgw

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Nobody Talks About The Money Fights You’ll Have After The Baby Comes

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I used to make good money. In fact, when I got engaged to my now ex-husband, I was making more than he was. Yes, he was a hard worker, but I was a few years older than him, had been in the workforce longer, and had been on my own for a while. We still split everything down the middle when we moved in, and he never complained or told me I should contribute more because I made more.

Then, after we got married and had babies right away, we decided together that I’d stay home with the kids. It was something we both wanted and were equally excited about. He started a company and did really well. He made more than enough to support our family, and we were both smart with our money. No credit card debt, didn’t live above our means, and neither of us were really extravagant.

But even in that situation, we still fought about money. I was used to contributing and going shopping to get a new outfit when I wanted. I also love going out to eat, and we did that regularly when we had two incomes. After we had a baby, though, and I went out to eat, my ex would make a comment about how it wasn’t really necessary and we should save as much as possible.

I agreed with the saving thing, but I didn’t want to stop living my life. We weren’t going out and doing things as much. I only shopped during sales, and as much as I wanted a new car, I didn’t push it because the one I had was fine.

I felt like I was making adjustments, but we still had arguments about spending. My ex was not a controlling man by any means, but he only enjoyed spending money on certain things. He didn’t care as much about going out to eat or staying up on the latest fashion trends. But those were two things that made me so happy. And frankly, they made me feel alive. We all need an outlet, something to look forward to, and those were my things.

In a way, I felt like he was trying to take that away from me, and I would not let that happen.

I started asking him for permission to spend money to avoid fighting about it. That didn’t work, as he’d say we should use any extra money to save for college funds or retirement. Even if I really wanted something, he’d come back with “You don’t need that.”I’d usually reply with something akin to “Just because you don’t care about how you dress doesn’t mean I have to live that way,” or “you get to leave the house every day and go to work, so going out to eat is something I really look forward to. I don’t want to make all the meals, and it’s not like you help.”

Needless to say, it brought out an ugly side in both of us. We had previously made such a great team, so I never expected for that to happen. Neither of us were right, of course. But there was a shift, a change. We both had to make sacrifices, and that’s hard. No one wants someone to tell them what they can’t and can’t do with money. My husband was under a lot of pressure, starting a business and going from supporting himself to supporting me and a child. I didn’t have enough empathy then, and he didn’t have empathy for the fact that I had lost some identity and freedom.

Yes, this was a sacrifice we both agreed to make, not knowing how hard it was going to be.

I had always worked, knew my budget, and treating myself to things was how I loved myself. And I felt like that was being threatened.

You may roll your eyes, or you may completely understand. All I know is that I’ve never talked to a couple that didn’t go through growing pains over money after they had a baby. Every situation is unique, is hard, and requires some tough talks and sacrifices.

It took a bit, but my ex and I finally got on the same page. It required both of us to make some changes because ultimately, the most important thing to us was for me to stay at home with the kids.

If you’re going through this with your partner, be gentle on yourself but also gentle on them. It’s likely that neither of you have been through this before, and there’s a learning curve.

Nobody really talks about the money fights you’ll have after the baby comes. Be prepared, and more importantly, remember that the faster you come to a comfortable place for both of you, the faster you can enjoy this new life. You’re allowed to change your mind about working. You’re allowed to get another job, or a different job. And letting go of some luxuries can actually be freeing.

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https://imgix.bustle.com/uploads/image/2025/8/25/2fd4a7a3/moneyfights_header.jpg?w=720&h=810&fit=crop&crop=facesI had always worked, knew my budget, and treating myself to things was how I loved myself. And I felt like that was being threatened.

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Click the link below for the complete article:

https://www.romper.com/romper-new-parent-finance

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Donor Who Gave $130 Million to Pay Troops Is Reclusive Heir to Mellon Fortune

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Timothy Mellon, a reclusive billionaire and a major financial backer of President Trump, is the anonymous private donor who gave $130 million to the U.S. government to help pay troops during the shutdown, according to two people familiar with the matter.

Mr. Trump announced the donation on Thursday night, but he declined to name the person who provided the funds, only calling him a “patriot” and a friend. But the two people, who spoke on the condition of anonymity because the donation was private, identified him as Mr. Mellon.

Shortly after departing Washington on Friday, Mr. Trump again declined to identify Mr. Mellon while talking to reporters aboard Air Force One. He only said the individual was “a great American citizen” and a “substantial man.”

“He doesn’t want publicity,” Mr. Trump said as he headed to Malaysia. “He prefers that his name not be mentioned, which is pretty unusual in the world I come from, and in the world of politics, you want your name mentioned.”

The White House declined to comment. Multiple attempts to reach Mr. Mellon and representatives for him were unsuccessful.

It remains unclear how far the donation will go toward covering the salaries of the more than 1.3 million troops who make up the active-duty military. According to the Congressional Budget Office, the Trump administration’s 2025 budget requested about $600 billion in total military compensation. A $130 million donation would equal about $100 a service member.

Mr. Mellon, a wealthy banking heir and railroad magnate, is a longtime backer of Mr. Trump and gave tens of millions of dollars to groups supporting the president’s campaign. Last year, he made a $50 million donation to a super PAC supporting Mr. Trump, which was one of the largest single contributions ever disclosed.

A grandson of former Treasury Secretary Andrew W. Mellon, Mr. Mellon was not a prominent Republican donor until Mr. Trump was elected. But in recent years, he has poured hundreds of millions of dollars into supporting Mr. Trump and the Republican Party.

Mr. Mellon, who lives primarily in Wyoming, keeps a low profile despite his prolific political spending. He is also a significant supporter of Health Secretary Robert F. Kennedy Jr., who also ran for president last year. Mr. Mellon donated millions to Mr. Kennedy’s presidential campaign and has also given money to his anti-vaccine group, Children’s Health Defense.

The Pentagon said it accepted the donation under the “general gift acceptance authority.”

“The donation was made on the condition that it be used to offset the cost of service members’ salaries and benefits,” Sean Parnell, the Pentagon’s chief spokesman, said in a statement.

Still, the donation appears to be a potential violation of the Antideficiency Act, which prohibits federal agencies from spending money in excess of congressional appropriations or from accepting voluntary services.

More than three weeks into the government shutdown, the Trump administration has taken a series of unorthodox steps to redirect funds to pay certain government workers.

Mr. Trump has vowed to pay military members, immigration agents, and law enforcement officials even though lawmakers have not approved the money for their wages. Workers in those categories are considered essential and must continue working during the shutdown, although they are entitled to back pay under a 2019 law.

As part of that promise, the president signed an executive order this month directing the Pentagon to use unspent research and development funds to cover troops’ salaries. But congressional leaders have warned that moving funds around is only a temporary fix.

Thousands of federal workers missed their first paycheck this week. About 670,000 workers have been furloughed, according to a tally by the Bipartisan Policy Center, a Washington-based think tank. An additional 730,000 or so are working without pay.

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Click the link below for the complete article:

https://www.nytimes.com/2025/10/25/us/politics/timothy-mellon-donation-troops.html?campaign_id=60&emc=edit_na_20251025&instance_id=165145&nl=breaking-news&regi_id=86018945&segment_id=209323&user_id=c20540e0b7c4bb9b7acd45efa2e77a96

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Van Jones: MAGA ‘bamboozled’ on Epstein files

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CNN pundit Van Jones said the “Make America Great Again” movement has been “bamboozled” over the Trump administration’s handling of records relating to disgraced financier and convicted sex offender Jeffrey Epstein.

“Look, MAGA has been took, had, bamboozled. I don’t know, like — look, you have everything that you just said, every Republican was saying, and now ‘nothing to see here,’” Jones, an ex-adviser to former President Obama, said Monday night on CNN’s “OutFront.”

“So Hakeem Jeffries is 100 percent correct. Either they were lying the whole time, saying they had all the goods on all these rich people, or they’re lying now and covering it up. Either way, if I were in MAGA, I might think to myself, what else are they being dishonest about? Somebody is tricking somebody,” the CNN political commentator told host Erin Burnett. 

House Minority Leader Hakeem Jeffries (D-N.Y.) said earlier Monday that the administration should release all of the files related to Epstein. The Democratic leader pointed to two possible scenarios of why the documents related to the case are not public. 

“Option 1: They lied for years. Option 2: They’re engaging in a cover-up. At this point. it seems reasonable that it can only be one of the two things,” Jeffries told reporters at the Capitol. “And so it’s Congress’s responsibility, in a bipartisan way, to ask the questions and try to get answers on behalf of the American people.”

Many MAGA supporters have been outraged over the administration’s posture around the Epstein case, particularly after the FBI and DOJ published a memo earlier this month stating there’s no evidence Epstein had a “client list” and reaffirming that he died by suicide in a jail cell in 2019 while awaiting trial on federal sex-trafficking charges. 

Attorney General Pam Bondi has faced strong blowback from the MAGA base. She said during a February Fox News interview that she had the Epstein client list on her desk, comments she clarified earlier this month, saying she meant she had the Epstein case file. Trump has stood by Bondi’s side, praising her on Saturday for doing a “FANTASTIC JOB” and told his backers to move on. 

Jones on Monday used the controversy to knock the Trump administration’s policies.

“Are they being dishonest when they say that there are tens of millions of violent immigrants, and therefore we should have people snatched off the streets? What else should you start asking questions about? Because obviously the people in charge of the Republican Party and the people in the White House are not being honest with you about this,” Jones said.

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The Hill

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Click the link below for the complete article (sound on to listen):

https://thehill.com/homenews/media/5401397-van-jones-trump-bamboozled-epstein-files/

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Infections of Drug-Resistant ‘Nightmare Bacteria’ Are Surging in Hospitals

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The U.S. Centers for Disease Control and Prevention is raising alarm about a sharp spike in infections from dangerous bacteria that are resistant to some of the strongest antibiotics.

A report released on Tuesday by CDC scientists found that, between 2019 and 2023, there was as much as a 461 percent increase in the infection rate of certain bacteria in the group Enterobacterales that can thwart many antibiotic treatments, including a powerful class of drugs known as carbapenems. Carbapenems are used to treat severe multidrug-resistant bacterial infections, including pneumonia and bloodstream, bone and urinary tract infections. These carbapenem-resistant Enterobacterales (CRE) infections are notoriously difficult to treat and can be fatal: In 2020 alone, CRE caused about 12,700 infections and 1,100 deaths in the U.S. Former CDC director Tom Frieden once called CRE “nightmare bacteria.”

The report’s authors note that CRE infections are still considered rare and mostly occur in hospital settings. Still, the rise in infections highlighted in the new study is cause for some concern.

“It was shocking to see how large of an increase it was,” says Danielle Rankin, a co-author of the new report and an epidemiologist at the CDC’s Division of Healthcare Quality Promotion. “The biggest thing for us is that we understand where this is happening because we want to ensure that this does not go outside of health care settings [and] into the community and cause more difficult-to-treat infections.”

What Did Researchers Find?

The group Enterobacterales encompasses a wide number of common germs, including Escherichia coli and Klebsiella pneumoniae. One way bacterial species turn into CRE is by picking up specific genes that allow them to evade antibiotics, such as by giving them the ability to make carbapenemases, enzymes that inactivate carbapenems.

The study’s authors analyzed cases in 29 states that require hospitals to report and send CRE samples to local public health departments for testing. They looked at overall changes in CRE infection rates, as well as the prevalence of five different types of genes that code for carbapenemases. Overall, the researchers found a 69 percent increase in the rate of CRE infections that involved carbapenemase-producing genes between 2019 and 2013. “We saw this increase in at least every region,” Rankin says.

Among CRE with these genes, those with a gene that codes for an enzyme called New Delhi metallo-β-lactamase, or NDM, had the largest jump in infection rate—461 percent. Such so-called NDM-CRE bacteria are known to spread easily through health care facilities via medical equipment such as ventilators and intravenous tubing. People receiving treatment in these care settings are currently at highest risk, but Rankin says it’s not out of the realm of possibility for NDM-CRE infections to occur in other environments.

“The antibiotics we have that are effective against NDM-CRE are only available through IV. They are not an oral antibiotic you can take,” Rankin says. “We are concerned because there is risk that this could spread into communities, meaning that common infections like urinary tract infections that are usually treated with the oral antibiotics may increasingly need to be treated with the IV antibiotics and require hospitalization.”

Rankin notes that the situation with NDM-CRE also plays a part in the larger antimicrobial resistance crisis. “These are genes that can transfer resistance across different bacterial species,” she says.

What’s behind the Increase in Infections?

CDC scientists are still investigating, but they suspect several factors are involved. NDM-CRE can spread from improper hand hygiene among health care providers or inadequate cleaning and disinfection of equipment. Other key factors are insufficient testing and limited access to detection tools. “When NDM-CRE infections are not identified quickly, earlier treatment with effective antibiotics and infection control interventions may be delayed, which can then create more opportunities for transmission from patient to patient,” Rankin says.

She hopes the report shows the importance of using specialized testing to detect these drug-resistant genes so that health care providers can deliver effective—and potentially lifesaving—treatments.

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https://static.scientificamerican.com/dam/m/e0691f7192cedeb/original/Klebsiella-pneumoniae.jpg?m=1758748607.839&w=900

Microbiologist holds a petri dish growing bacteria, Klebsiella pneumoniae, one species that can become resistant to last-resort antibiotics.  Eric Carr/Alamy Stock Photo

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Click the link below for the complete article:

https://www.scientificamerican.com/article/nightmare-bacteria-infections-spiking-leaving-key-carbapenem-antibiotics/?_gl=1*gas14d*_up*MQ..*_ga*MzUzNTg2MTk0LjE3NjEzODA3MDM.*_ga_0P6ZGEWQVE*czE3NjEzODA3MDIkbzEkZzAkdDE3NjEzODA3MDIkajYwJGwwJGgw

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How Ayo Edebiri Became the Adult in the Room

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I have been with Ayo Edebiri for 15 minutes, tops, and already I’m getting her Pacino.

“What have I been listening to? I’ve been listening to, honestly, the Sonny Boy audiobook,” she tells me, unprompted, after we’ve ducked into her compact car. “You’re literally like, Wait, how is this a book? The way he delivers lines? It’s really shocking. Every actor should listen to that book. He goes—my impression of him is if RFK was raised in the Trump household. It’s like: ‘I had no idea! My mutha…gave me away…for six months…because my fatha’ ”—she takes on here the affect of a very sad clown—“ ‘wasawayinthewar.’ I’m actually going to pull it up.”

The plan for our morning is almost satirically LA: After meeting at 8 a.m. at a matcha place in Highland Park, she’s to drive us to a hiking trail in Angeles National Forest. (She’s an early riser, something that she attributes, in part, to being a former New Yorker: “No matter how early you get up in New York, there’s always somebody who’s either earlier or their day hasn’t finished. But in LA, it’s office hours.”) Dressed in a baseball tee emblazoned with the NBC logo, track pants, a printed headscarf—not unlike the ones she wears as Sydney Adamu, the hyper-competent, superdriven, rather anxious young sous-chef on The Bear, in fact—and Prada sunglasses, she certainly looks the part of a 20-something somebody in the industry, taking the air before she tootles down to Studio City for “meetings,” or whatever actors do. (In reality, Edebiri is due on Hollywood Boulevard later that day for an appearance on Jimmy Kimmel Live!.)

She’s been out here for five or six years—moving from Brooklyn, where she put down roots after attending NYU, when she began writing for television. But it took quite some time for Los Angeles to feel like home. “I don’t really think I started to enjoy living here until last year,” Edebiri says, swirling her iced latte. “I liked it, but I don’t think it really meant anything to me. And I missed a lot of my friends on the East Coast.”

What changed things was hanging out with people like Lionel Boyce, one of her costars on The Bear, and his former Odd Future bandmates Tyler, the Creator, and Travis Bennett—native Angelenos all—who helped her find her footing in the city’s sprawl. (Asked what they like to do when they see each other, Tyler makes his and Edebiri’s milieu sound more like suburban teenagers than very famous adults. “We loiter,” he says. “We’ll sit in the parking lot. We’ll go to someone’s house and play Uno. We’ll eat. It’s just the most normal shit you could think of.”)The strangeness of life in LA this year has also done its part to affirm her sense of community: In January, Edebiri was one of the hundreds of thousands evacuated during the wildfires (her home was ultimately unharmed, but she has friends and colleagues who weren’t so lucky), and at the time of our first interview, downtown LA had recently been under curfew due to the anti-ICE and “No Kings” protests of the days prior.

Edebiri had been out marching over the weekend; the sign she carried—now in her car’s backseat next to Gromit, her dozing Chihuahua mix—reads “Don’t tread on us,” a riff on the Gadsden flag from the Revolutionary War. (Very Boston-native of her, really.)

“It was actually amazing,” she says. “We’re in such a weird empathy drought, which it’s hard not to be—you want to save your own skin. But it’s like, If we’re supposed to be evolved people, we extend care to each other.” And then, in the very same breath: “Do you want sunscreen?”

Raised in the Dorchester neighborhood of Boston, Edebiri is the only child of a Nigerian father and a strictly Pentecostal Barbadian mother. She’s said there was a time when her greatest aspiration was to be a pastor’s wife, but then she got into improv and theater at her public school and started recording episodes of 30 Rock and Conan at home. In college, Edebiri veered from majoring in education to studying dramatic writing at Tisch, meeting, along the way, friends and collaborators like Rachel Sennott, her costar in the 2023 film Bottoms (directed by Emma Seligman, another NYU alum); and Tyler Mitchell, who has now photographed her for this magazine twice. (“We met at a Halloween party,” Edebiri recalls of Mitchell. “I was dressed as Solange on the cover of A Seat at the Table, and he was dressed as Young Frankenstein. And we looked at each other and we said, ‘We are friends.’ ”)

Well-placed writing- and production-assistant jobs, paired with a growing profile in New York’s stand-up comedy scene, led eventually to Edebiri’s first writing credits—on series like the short-lived NBC sitcom Sunnyside, Apple TV+’s Dickinson, Netflix’s Big Mouth, and FX’s What We Do in the Shadows—as well as some supporting and voice-acting roles. But it was appearing on The Bear, which premiered in 2022, that made Edebiri suddenly, and quite unexpectedly, a proper star.

Critics have jabbed at The Bear for competing for awards as a comedy series, when really it walks and talks like a lightly comic drama. Whatever it is, an upshot of its tonal ambiguity has been getting to see someone as obviously, instinctively funny as Edebiri play in every kind of key: delivering punch lines and making wry asides, sure, but anchoring surreal dream sequences and executing sobbing monologues too. “She’s very smart but also silly,” says the actor, writer, and director Will Sharpe, with whom Edebiri will soon star in the Apple TV+ show Prodigies. “She has the ability to be a serious, sophisticated, dramatic actor, but also has funny bones.”

The performance as Sydney has won Edebiri an Emmy, a Golden Globe, a Screen Actors Guild Award, and a Critics’ Choice Award, among other prizes. So, too, did The Bear—and the deft work of Danielle Goldberg, Edebiri’s stylist and good friend, on all those important red carpets—launch her into the fashion firmament: Suddenly, Edebiri was flitting freely between high-femme silhouettes and looks drawn from menswear, whether in a red satin column from Prada for the 2024 Golden Globes or a floor-length shirtdress and leather tailcoat from Ferragamo for May’s Met Gala. And then, this fall, in a true cool-girl coup, she was named a brand ambassador for Matthieu Blazy’s new Chanel.

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https://assets.vogue.com/photos/68dc1e87b3a906caf4b7f5a6/master/w_1600,c_limit/VO1125_Cover_logo_AE.jpgEdebiri wears a Chanel top, necklace, and earring. Fashion Editor: Alex Harrington.Photographed by Tyler Mitchell. Vogue, November 2025.

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Click the link below for the complete article:

https://www.vogue.com/article/ayo-edebiri-november-cover-2025-interview

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