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NIH Funding Cuts Would Hobble U.S. Medical Research, Insider Says

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Hmmm…Impeachment?

 

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The U.S. National Institutes of Health announced on February 7 it was immediately cutting some $4 billion a year in funding to biomedical researchers nationwide. The move would reduce the share of NIH grants paid to “indirect” costs—lab upkeep, administration, and operation—to 15 percent, cutting their historical rate almost in half, overnight.

In the announcement, NIH said that of roughly $35 billion spent funding 300,000 researchers nationwide in 2023, $9 billion went to indirect costs. The move to a lower indirect cost rate, it argued, put them more in line with those put in place by private foundations.

On February 10 in response, 22 states filed a federal lawsuit, “to protect their states and residents from unlawful action by the National Institutes of Health (‘NIH’) that will devastate critical public health research at universities and research institutions in the United States.”

Donald Trump proposed dropping NIH’s indirect cost rate to 10 percent in 2017, but faced congressional resistance. As was the case then, the newly proposed cuts have triggered widespread criticism from scientists, who say it endangers patients and the U.S. strategic advantage in research. “Frankly, this means that the lives of my children and grandchildren—and maybe yours—will be shorter and sicker,” medical professor Theodore Iwashyna of Johns Hopkins University told CNN.

Indirect costs eating into lab grants have long triggered complaints from scientists, but a 2014 Nature analysis concluded that “overall, the data support administrators’ assertions that their actual recovery of indirect costs often falls well below their negotiated rates.”

Scientific American spoke to David Skorton, president of the Association of American Medical Colleges, which represents all the medical degree–granting schools in the U.S., about this shift, and its effects on medicine.

[An edited transcript of the interview follows.]

How does this affect people who may have never heard of “indirect” NIH grants before, but who get sick or know people who could benefit from better medicine?

So the idea of biomedical research is multifaceted. Some of it is meant to help understand the way life works. Over a decade of research led to the idea that messenger RNA, a basic building block of biology, for example, could actually be used as a platform for vaccines. That knowledge was very basic, very fundamental, and eventually fed into Operation Warp Speed and the development of vaccines against COVID-19. So that’s one thing.

Then there are research projects that you might call applied research, like cancer clinical trials. Someone unfortunately has cancer, and basic research has shown that perhaps a new approach, like immunotherapy, harnessing the immune system to fight off cancer cells, might help. We need to find out, so it goes to human, clinical trials. Those clinical trials are also research projects. And then there are research projects that have to do with diagnosing illnesses. Not treating it. I did some research early in my career on computer processing medical images from the cardiovascular system. The idea there was to develop better diagnostic techniques that could lead to a quicker way to diagnose an illness. So that you know the right treatment.

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https://static.scientificamerican.com/dam/m/764142bb6daf350f/original/national_institutes_of_health_headquarters.jpg?m=1739221228.287&w=1000

National Institutes of Health (NIH) campus, Bethesda, Maryland. Grandbrothers/Alamy Stock Photo

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Click the link below for the complete article:

https://www.scientificamerican.com/article/nih-funding-cuts-would-hobble-u-s-medical-research-insider-says/

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Go Ahead, Take That Video

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It’s one of my favorite 47 seconds of all time.

On the video playing on my phone, a pigtailed toddler gleefully shrieks as she loses a battle with an unruly sprinkler head in a grassy lawn.

It’s a great memory that feels as if it were taken yesterday. But this soaking wet and positively joyful girl—my daughter—is nearly 13 years old and has long since ditched the pigtails. Another video of my younger daughter polishing off a plate of “skabetti” is a close second, and one played just as often.

As parents, it is very much our birthright to capture childhood. The classic go-to for documenting is, of course, the baby book. And look, I tried. My firstborn was the beneficiary of a well-meaning effort to capture and curate milestones in a pastel-colored, polka-dot baby book. It starts off strong but then dramatically tapers off (because life). My second kid has maybe a shoebox with milestones hastily recorded on a Post-it (because second kid).

But I make up for it by saving snippets of their childhood in another way. Like that of many parents, my phone contains lots of videos of my kids. In addition to the delightful sprinkler showdown, there are clips of soccer games, recitals, birthdays. It is a robust repository—hundreds of videos taking up hundreds of gigabytes.

Whenever the time comes for me to upgrade to a new phone, these old videos come with me, thank you very much. I have, at the ready and at any moment, easy access to their early years—from a first encounter with snow to their budding inquiries at dinnertime (“What do badgers eat?” “Were you and Abraham Lincoln friends?”).

Some find the fact that Generation Alpha has such hyperdocumented childhoods to be alarming and potentially harmful. But as long as your knee-jerk reaction isn’t to immediately put all these photos and videos online and you can balance being present in the moment, these gigabytes of still and moving images are an unalloyed blessing.

But I make up for it by saving snippets of their childhood in another way. Like that of many parents, my phone contains lots of videos of my kids. In addition to the delightful sprinkler showdown, there are clips of soccer games, recitals, birthdays. It is a robust repository—hundreds of videos taking up hundreds of gigabytes.

Whenever the time comes for me to upgrade to a new phone, these old videos come with me, thank you very much. I have, at the ready and at any moment, easy access to their early years—from a first encounter with snow to their budding inquiries at dinnertime (“What do badgers eat?” “Were you and Abraham Lincoln friends?”).

Some find the fact that Generation Alpha has such hyperdocumented childhoods to be alarming and potentially harmful. But as long as your knee-jerk reaction isn’t to immediately put all these photos and videos online and you can balance being present in the moment, these gigabytes of still and moving images are an unalloyed blessing.

It’s a privilege to be able to so effortlessly indulge my nostalgia whenever I want. For many adults my age, seeing snaps of our childhood might be limited to whenever we have a chance to visit our parents’ house. It requires some effort to unearth dusty albums from basements and closets. The ritual of sitting together to watch family videos also requires some time. Set up the VCR; dig up the tapes. Rewind, fast-forward, rewind.

There is a redemptive element at play here. My childhood lives in the carefully curated and compartmentalized memory of my mind. There is virtually no record of my own early years, with only a handful of photos and certainly no videos. In the 1980s, the time of camera film and camcorders, my parents didn’t invest in making a record, and the dysfunction of my fractured family life ensured that there were very few moments worth committing to film or ever watching on playback.

But I’m not alone when it comes to my fierce attachment to these old videos. It turns out, the subjects of these videos are kind of obsessed with watching themselves.

My kids eagerly press Play and relive it all: the unmistakable lilt of their little baby voices, unsteady first steps, charmingly off-key renditions of Disney songs, and wary standoffs with anything remotely resembling a vegetable on their plate.

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https://compote.slate.com/images/b8133ddb-c9af-4d27-9b71-973d406e5ea3.jpeg?crop=1560%2C1040%2Cx0%2Cy0&width=1280Scaliger/iStock/Getty Images Plus

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Click the link below for the complete article:

https://slate.com/life/2025/02/kids-smartphones-videos-photos-storage.html?utm_source=pocket_discover_parenting

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Court Square-Dexter Avenue Historic District of Montgomery, Alabama

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Court Square-Dexter Avenue Historic District of Montgomery, Alabama

On This Day: February 09, 1960

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On This Day: February 09, 1960

Mathematicians Solve Infamous ‘Moving Sofa Problem’

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For those who have wrestled a bulky couch around a tight corner and lamented, “Will this even fit?” mathematicians have heard your pleas. Geometry’s “moving sofa problem” asks for the largest shape that can turn a right angle in a narrow corridor without getting stuck. The problem sat unsolved for nearly 60 years until November, when Jineon Baek, a postdoc at Yonsei University in Seoul, posted a paper online claiming to resolve it. Baek’s proof has yet to undergo thorough peer review, but initial passes from mathematicians who know Baek and the moving sofa problem seem optimistic. Only time will tell why it took Baek 119 pages to write what Ross Geller of the sitcom Friends said in one word.

The solution is unlikely to help you on moving day, but as frontier math grows more abstruse, mathematicians hold a special fondness for unsolved problems that anybody can understand. In fact, the popular math forum MathOverflow maintains a list of “Not especially famous, long-open problems which anyone can understand,” and the moving sofa problem currently ranks second on the list. Still, every proof expands our understanding, and the techniques used to resolve the moving sofa problem will likely lend themselves to other geometric puzzles down the road.

The rules of the problem, which Canadian mathematician Leo Moser first formally posed in 1966, involve a rigid shape—so the cushions don’t yield when pressed—turning a right angle in a hallway. The sofa can be any geometric shape; it doesn’t have to resemble a real couch. Both the shape and the hallway are two-dimensional. Imagine the sofa weighs too much to lift, and you can only slide it.

A quick tour through the problem’s history reveals the extensive effort that mathematicians have poured into it—they were no couch potatoes. Faced with an empty hallway, what is the largest shape you could squeeze through it? If each leg of the corridor measures one unit across (the specific unit doesn’t matter), then we can easily scoot a one-by-one square through the passage. Elongating the square to form a rectangle fails instantly, because once it hits the kink in the hallway, it has no room to turn.

Yet mathematicians realized they can go bigger by introducing curved shapes. Consider a semicircle with a diameter (the straight base) of 2. When it hits the turn, much of it still overhangs in the first leg of the hallway, but the rounded edge leaves just enough room to clear the corner.

Remember the goal is to find the largest “couch” that slides around the corner. Dusting off our high school geometry formulas, we can calculate the area of the semicircle as π/2, or approximately 1.571. The semicircle gives a significant improvement over the square, which had an area of only 1. Unfortunately, both would look strange in a living room.

Solving the moving sofa problem requires that you not only optimize the size of a shape but also the path that shape traverses. The setup permits two types of motion: sliding and rotating. The square couch only slid, whereas the semicircle slid, then rotated around the bend, and then slid again on the other side. But objects can slide and rotate at the same time. Mathematician Dan Romik of the University of California, Davis, has noted that a solution to the problem should optimize both types of motion simultaneously.

British mathematician John Hammersley discovered in 1968 that stretching the semicircle can buy you a larger sofa if you carve out a chunk to deal with that pesky corner. Furthermore, Hammersley’s sofa takes advantage of a hybrid sliding plus rotating motion. The resulting sofa looks like a landline telephone:

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https://static.scientificamerican.com/dam/m/2b5e0c75e43736b8/original/Couple-carrying-couch.jpg?m=1738693306.648&w=1000RgStudio/Getty Images

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Click the link below for the complete article:

https://www.scientificamerican.com/article/mathematicians-solve-infamous-moving-sofa-problem/

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The Age of the Unique Baby Name

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These days, if you hear about the birth of an Olivia or a Liam, you might feel a pang of sympathy—the poor child has been cursed with the most popular name of their time and might be at risk of sharing it with a kindergarten classmate.

This wasn’t always considered an undesirable outcome. The name Mary, for instance, was the most popular girls’ name for all but six years from 1880 to 1961, and “if you talk to people from earlier generations, [they’ll say] ‘Well, of course, there were five Marys in the class,’” Laura Wattenberg, the founder of the naming-trends site Namerology, told me. “That didn’t matter. There wasn’t that kind of fear.”

In the past 60 or so years, American parents’ approach to naming their kids has undergone a profound shift. Today, many parents seek out less popular names to help their kids stand out. But in the past, parents typically picked common names, consciously or not, so that their kids would fit in.

In 1880, the percentage of babies who got a top-10 most popular name was in the neighborhood of 32 percent, according to Wattenberg’s calculations. In 1950, it was about 28 percent. And in 2020, it had fallen to an all-time low of 7 percent. “We are deep in an era of naming individuality, where parents assume that having a [name] sound distinctive and unique is a virtue,” Wattenberg said.

For much of American history, many people just named their kids after someone on the family tree, which helped keep names in circulation for a long time. This was especially true for baby boys, who have historically had less varied names than baby girls in part because they were more likely to inherit a family name. For instance, in Raleigh Colony, roughly one in two boys had the name John, William, or Thomas. Those three names remained in or near the top 10 from the 1880s, when the Social Security Administration’s records begin, through the 1960s.

Of course, some names from earlier eras did stand out. Puritan names like Patience, Temperance, and Standfast had explicit moral heft. Immigrants injected some variety by using names from their home countries, but also sometimes opted for (or felt pressured to pick) “whiter-sounding” names in hopes of fitting in. And there was some charming regional diversity. Early-20th-century Oklahoma produced names like Ovonual and Odelene. In southern Appalachia, there were kids named Meek, Bent, Wild, Whetstone, Speed, and AnvilThe last decades of relatively uniform naming were the 1940s and ’50s. In 1955, for example, half of all American babies born had one of just 78 names, according to Wattenberg. In 2019, that number was 520. Parents’ inclination toward sameness in the ’40s and ’50s might have had to do with the unifying effect of living through the Great Depression and World War II. Those events “gave them a sense of solidarity with the whole culture, the whole country,” Cleveland Evans, a professor emeritus of psychology at Bellevue University and an expert on names, told me. At a time when the path to success seemed communal, being like other people wasn’t seen as a bad thing.

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baby wearing blank nametagJamie Grill/Getty Images

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Click the link below for the complete article:

https://getpocket.com/explore/item/the-age-of-the-unique-baby-name

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Slave Markets and Jails in United States

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Slave Markets and Jails in United States

Professional Soccer Players May Demonstrate Exceptional Cognitive Control

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Soccer fans sometimes imagine that they themselves could potentially perform at the highest levels of the sport, just like the athletic heroes they watch on the pitch. But if they ever do find the chance to try, they will learn that their body simply won’t cooperate—and they might even get seriously hurt. And many of them are ignoring the fact that the “beautiful game” is also a brain game. Reporting in the Proceedings of the National Academy of Sciences USA, an

international research group says it has now confirmed that success on the soccer field is about mind as well as body. The team, co-led by Leonardo Bonetti of Aarhus University in Denmark and the University of Oxford, examined elite soccer players’ intelligence and personality types and discovered they have exceptional cognitive abilities—as well as a typical psychological profile.

The participants comprised more than 200 professional players from Brazil and Sweden, about 9 percent of whom were women, along with a control group of 124 Brazilian nonathletes with a similar education level and social background. The subjects filled out a personality questionnaire and completed several cognitive tests. The researchers compared the results for the athletes with the same measures in the control group and the general population.

Among other things, the professional players demonstrated a better working memory and showed better performance in planning and problem-solving. But above all, they really shined when it came to executive function—the regulation of information processing in higher-order brain areas that helps someone adapt to fast-changing events. In particular, the elite athletes performed far above the norm on the design fluency test, a measure of cognitive flexibility.

The design fluency test had proved to be a good marker of intelligence on the soccer field in previous studies, with higher scores indicating players who had superior skills in developing strategy and analyzing the play around them. “The ability to plan several steps ahead in order to reach a goal in a quickly changing environment may be one of the most crucial cognitive processes related to successful behavior in complex ball sports such as soccer,” Bonetti and his colleagues write in their new paper.

In the personality test, the professional athletes also demonstrated pronounced self-discipline, energy, extraversion and other factors—all unsurprising results. But at first glance, one thing did not fit the picture of success in a team sport: the players were assessed to be less sociable and cooperative than other people, perhaps because they were so focused on their own performance.

Other studies had previously shown that professional soccer players have a unique cognitive profile—but these investigations had smaller samples that often did not include top players. “Our novel study reproduced previous results but can also be regarded as the first conclusive study,” says Predrag Petrovic, co-senior author of the new paper and a senior lecturer of clinical neuroscience at the Karolinska Institute in Stockholm. (Elite players demonstrate cognitive skills above the norm. But the nature of the game can compromise those superior abilities. The frequent heading of the ball and the collisions with other players can lead to head injuries that put players at higher risk for dementia.)

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https://static.scientificamerican.com/dam/m/63cd2e34dc7eef7/original/Soccer-player-making-sliding-tackle.jpg?m=1738952525.377&w=1000Andreyuu/Getty Images

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Click the link below for the complete article:

https://www.scientificamerican.com/article/professional-soccer-players-may-demonstrate-exceptional-cognitive-control/

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On This Day: February 08, 1968

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On This Day: February 08, 1968

Radio

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Received These links from A Friend

For those of us who grew up listening to the radio –

Have fun!

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If you have nothing to do for the next 6 to 10 years you can play with this.

Here’s an unbelievable collection of old-time radio shows.

This is a chance to go back in time and listen to the radio.

Find your favorite, click on it, and listen to some of the episodes.

Remember Dragnet and Bergen & McCarthy?

 

Comedy
Al Jolson Show
Alan Young Show
Aldrich Family
Alka Seltzer Time
Amos & Andy
Avalon Time
Baby Snooks
Bergen & McCarthy
Bickersons, The
Bing Crosby
Bob & Ray
Breakfast In Hollywood
Bright Star
Burns & Allen
Cavalcade Of America
Command Performance
Couple Next Door
Curtain Time
Danny Kaye Show
Dennis Day Show
Duffy’s Tavern
Easy Aces
Father Knows Best
Fibber McGee & Molly
First Nighter Program
Frances Langford Show
Fred Allen Show
Fred Waring Show
Gasoline Alley
GI Journal
Glenn Miller
Goldbergs
Great Gildersleeve
Guest Star
Halls Of Ivy
Harold Peary
Harry James Show
Hollywood Barn Dance
It Pays to Be Ignorant
Jack Benny
Life Of Riley
Lum And Abner
Mail Call
Mayor of the Town
Mel Blanc
Milton Berle
Misadventures Of Si and Elmer
My Favorite Husband
My Friend Irma
Our Miss Brooks
Phil Harris & Alice Faye
Red Skelton
Story Lady, TheWesterns
American Trail
Cisco Kid, The
Fort Laramie
Frontier Fighters
Frontier Gentleman
Frontier Town
Gene Autry
Gunsmoke
Have Gun Will Travel
Hopalong Cassidy
Horizons West
Lone Ranger A
Lone Ranger B
Roy Rogers Show, The
Six Shooter
Tales Of The Texas Rangers
Detective
Barry Craig
Boston Blackie
Broadway Is My Beat
Casey, Crime Photographer
Chase, The
Crime Classics
Crime Club
Crime Does Not Pay
Danger, Dr. Danfield
Dick Tracy
Dragnet
Falcon, The
FBI In War And Peace, The
Federal Agent
Frank Race
Gangbusters
Guilty Party
I Was A Communist For The FBI
Jeff Regan
Let George Do It
Lineup
Mr. District Attorney
Mr. Keene, Tracer of Lost Person
Nero Wolfe
Night Beat
Pat Novak
Philip Marlowe
Saint, The
Secrets Of Scotland Yard
Sherlock Holmes
This Is Your F.B.I
Yours Truly Johnny DollarMystery
Adventures By Morse
Arch Obler’s Plays
Beyond Midnight
Black Museum
Cloak and Dagger
Clock, The
Creaking Door
Dangerous Assignment
Dark Fantasy
Dark Venture
Darkness
David Harding Counter Spy
Diary of Fate
Dimension X
Escape
Five Minute Mysteries
Frankenstein
Ghost Corps
Green Valley Line
Hall Of Fantasy
Haunting Hour, The
Hermits Cave
I Love A Mystery
Incredible, But True
Inner Sanctum, The
Lights Out
Macabre
Man Called X, The
Molle Mystery Theater
Mysterious Traveler
Mystery In The Air
Quiet Please
Sealed Book
Shadow, The
Strange Dr. Weird
Suspense
Weird Circle
Whistler, The
Witch’s Tale
X Minus One
Drama
Academy Award Theater
Adventure Theater
Adventures By Morse
Air Adventures Of Jimmy Allen
Archie Andrews
Audio History
Avenger
Avengers
Big John & Sparky
Big Town
Bill Sterns Sports Reel
Birdseye Open House
Blackstone, The Magic Detective
Blue Beetle
Box 13
British Shows 1
British Shows 2
Campbell Playhouse
Captain Midnight
Chandu The Magician
Chesterfield Chicago Theater Of
Cinnamon Bear
Columbia Workshop
Commercials
Corsican Brothers
Damon Runyon Theater
Dangerously Yours
Family Theater
Fifth Horseman
Fighting AAF
Fire Fighters
Flash Gordon
Ford Show Ford Theater
Frank Merriwell
Future Tense
Goon Show, The
Grand Hotel Grand Marquee
Hallmark Playhouse
Heartbeat Theater
Hollywood Star Playhouse
Hop Harrigan
Horizons West
Humphrey Bogart
I Love Adventure
Information Please
Jungle Jim
Lets Pretend
Little Orphan Annie
Lux Radio Theater 465
Magic Island
Matinee Theater
Mercury Summer Theater
Mercury Theater
Michael Shayne
Miscellaneous Music
Moon Over Africa
Moon River
Mr. President
Railroad Hour
Sears Radio Theater
Smilin Ed’s Buster Brown Gang
Soap Operas
Soldiers of the Press
Speed Gibson
Sports Thrills
Superman
Tarzan
Treasury Star Parade
Treasury Star Salute
Vic & Sade
World Adventures Club
World War II Shows
WSJV Complete Broadcast Day
Your Army Air Force

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