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Heart disease in young women projected to rise sharply by 2050

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Heart disease is the top cause of death for women in the U.S.; it kills more of them than all forms of cancer combined. But the unique signs and symptoms of heart disease in women are more likely go undetected and untreated than those in men.

The dangers heart disease poses to women may be about to get worse, according to a new analysis. Based on national data between 2010 to 2020, researchers project that, by 2050, the prevalence of serious cardiovascular disease and stroke in women in the U.S. will rise from 10.7 percent to 14.4 percent—affecting more than 22 million people. And that’s not counting high blood pressure.

The study, published today in Circulation, also shows an alarming uptick of disease in younger women: nearly a third of all women between age 20 and 44 will be diagnosed with some form of cardiovascular disease by 2050.

Bar charts show projected changes in prevalence of cardiovascular diseases among U.S. women, by age and race or ethnicity, from 2020 to 2050.

Amanda Montañez; Source: “Forecasting the Burden of Cardiovascular Disease and Stroke in Women in the United States through 2050: A Scientific Statement from the American Heart Association,” by Karen E. Joynt et al., in Circulation, Vol. 153. Published online February 25, 2026 (data)

The projection is “really a wake-up call,” says Karen Joynt Maddox, lead author of the study and a cardiologist at Washington University in St. Louis. She is also vice chair of the Council on Quality of Care and Outcomes Research at the American Heart Association, which publishes these forecasts every year.

“Despite all of our amazing advances in treating cardiovascular disease, we have not made many advances in preventing the disease. And in fact, the projections would suggest that we’re doing worse and worse in preventing the cardiovascular risk factors,” she says.

The estimates represent a setback in the fight against cardiovascular disease, says C. Noel Bairey Merz, a cardiologist at Cedars-Sinai Medical Center in Los Angeles, who was not involved in the study.

“We had this idea that maybe by the end of this century, cardiovascular disease would be a rare condition,” Bairey Merz says. “Up until 2010, we had gotten cardiovascular disease down to one in four women, and now we’re back to one in three. It’s a sad reality.”

Hypertension—a form of high blood pressure that is an early risk factor of heart disease—could spike, according to the projections. Nearly 60 percent of women will have high blood pressure by 2050—up from 50 percent in 2020. And the rates of numerous cardiovascular conditions, such as coronary disease, heart failure, stroke and atrial fibrillation could all rise slightly, according to the study. By 2050, the prevalence of diabetes could increase by 10 percent, while that of obesity may increase by about 17 percent. Similar trends were observed in girls aged two to 19, with obesity predicted to increase from 19.6 percent to 32 percent by 2050.

“Cardiovascular disease is a life course disease. We can see risk factors start in childhood,” Joynt Maddox says. “I worry a lot about the increases that we’re projecting in young people, about setting people up for having heart problems when they’re in their 30s and 40s and 50s instead of their 60s and 70s and 80s.”

Bar charts show projected changes in prevalence of high blood pressure, obesity, high cholesterol and diabetes among U.S. women from 2020 to 2050.

Amanda Montañez; Source: “Forecasting the Burden of Cardiovascular Disease and Stroke in Women in the United States through 2050: A Scientific Statement from the American Heart Association,” by Karen E. Joynt et al.,

Older women have a higher prevalence of disease, but cardiovascular risk factors are high and rising in younger groups. Those two trends could feed each other in a vicious cycle, Joynt Maddox explains. As women age, they might experience greater rates of cardiovascular disease associated with a prior heart or metabolic issue. People with a past history of stroke and heart attacks are more likely to die from heart failure years later.

Similar trends could be seen in men, Joynt Maddox says. “It’s not that women are uniquely experiencing the increase in obesity or high blood pressure, but there are additional layers on top of that,” she adds.

Part of the reason why women may be at particular risk could relate to the significant hormonal changes they experience throughout life, including during menstruation, pregnancy and menopause, Joynt Maddox says. Determining how these life events affect heart health will require more research, but these are “issues that we can definitely build upon,” Bairey Merz says.

Socioeconomic and demographic factors also affect outcomes. For example, Black women have the highest incidence of high blood pressure, obesity and diabetes, which are all cardiovascular disease risk factors, and this is expected to still be the case in 2050. They could also see the gr

eatest jumps in heart failure and stroke, according to the new predictions.

“The double whammy is these intersectionalities—you’re Black or brown, and you live in a rural or underserved area, and you have absolutely no access to health care or insurance,” Bairey Merz says.

These racial health disparities are well documented, but the new forecast underscores the need for better prevention measures and health care policies, Joynt Maddox says. New glucagonlike peptide 1 (GLP-1) drugs, for example, could help mitigate rates of cardiovascular disease and obesity. How much GLP-1 drugs will do this “is an enormous unanswered question,” says Joynt Maddox, adding that the data the projections are based on do not fully overlap with the rise in GLP-1 drugs. “But I’m optimistic that it’s going to be part of helping us bend the curve.”

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https://static.scientificamerican.com/dam/m/511fbe93254d7731/original/GettyImages-2261207901_heart.jpg?m=1772028485.505&w=900KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty Images

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Columbia president says student was detained by DHS agents who claimed they were looking for missing child

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A Columbia University student was detained Thursday morning by immigration agents who misrepresented themselves by saying they were looking for a missing child to get access to a residential building, the university’s top administrator said.

Elmina Aghayeva, who is from Azerbaijan, was later released, but the school’s acting president, Claire Shipman, and others condemned the agents’ actions in the alleged 6 a.m. incident in an off-campus Columbia building.

“This was a frightening and fast-moving situation and utterly unacceptable for our students and staff,” Shipman said in a statement.

The Department of Homeland Security said Immigration and Customs Enforcement agents arrested Aghayeva and said her student visa had been terminated in 2016 “for failing to attend classes.”

“The building manager and her roommate let officers into the apartment,” the DHS statement said.

Aghayeva said Thursday afternoon in an Instagram story that she had been released and was on her way home. “I am safe and okay,” she wrote, adding that she was in “complete shock over what happened.”

The hours before she was released were marked by growing outrage and concern over how she was arrested.

Shipman said five federal agents entered the off-campus Columbia building “without any kind of warrant.”

“The agents gained entry by stating they were police searching for a missing child,” she said. “They made their way to the apartment of the student they were targeting with the same story.”

A representative from DHS said its agents wore badges around their necks and verbally identified themselves.

Shipman said the agents flashed a photo of the purported missing child, which was captured on security video, as part of the false story. She also said the agents did not show a university public safety officer any warrant.

“A public safety officer arrived, asked multiple times for a warrant, which was not produced, and asked for time to call his boss, which was not given,” Shipman said. “The agents took our student.”

Public officials were alarmed over the university officials’ allegation, including New York Mayor Zohran Mamdani. Mamdani, who is in Washington, wrote on X that he spoke with President Donald Trump about concerns over the arrest.

“He has just informed me that she will be released imminently,” Mamdani wrote shortly before Aghayeva shared news of her release.

Gov. Kathy Hochul condemned the detention of the student and said “a rogue deportation agenda is operating with zero transparency and even less accountability.”

She also referred to Nurul Amin Shah Alam, a nearly blind refugee who was found dead in Buffalo, New York, after authorities said Customs and Border Protection left him at a coffee shop.

“Yesterday, a blind father was released from federal custody and left alone on the street to find his way home. He never made it back to his family. This morning, ICE agents misled campus security and took a young woman from her college dorm without a judicial warrant,” Hochul said.

Senate Minority Leader Chuck Schumer, D-N.Y., described the allegations as “unacceptable” on X. He said his office was working closely with Columbia and authorities on the matter.

“It is outrageous that ICE agents falsely represented themselves to arrest a Columbia graduate student by entering university-owned housing without a warrant,” he wrote.

Aghayeva is an international student with a visa, according to a statement her friends released through a faculty organization, the American Association of University Professors. She is in her senior year, majoring in neuroscience and political science.

The statement added that she was taken from her Columbia housing building on West 121st Street. 

Aghayeva’s lawyer filed a habeas corpus petition with the Southern District of New York on Thursday, a copy of which was obtained by NBC News. It says that she entered the U.S. in or around 2016 on a visa and that no reason was given for her detention.

An attorney for Aghayeva did not immediately respond to a request for comment.

Several student groups, including Columbia Student Apartheid Divest, called for an emergency rally “to protest the detention of an undergrad from a Columbia building.” The demonstration outside the university gates drew about 100 people, according to the college newspaper, the Columbia Spectator.

In the letter, Shipman reminded the campus community that law enforcement agents must have judicial warrants or judicial subpoenas to access nonpublic areas of the school. If law enforcement requests access, she said, students, faculty and staff members should ask the agents to wait and then contact the university’s public safety office.

“Do not allow them to enter or accept service of a warrant or subpoena,” Shipman urged.

“An administrative warrant is not sufficient” to access nonpublic areas of the campus, she added.

NBC News has reported that an internal ICE memo in May said agents are allowed to forcibly enter a home using an administrative warrant if a judge has issued a “final order of removal.” That is a departure from previous norms, in which a warrant signed by a judge or a magistrate was necessary for agents to forcibly enter homes.

The university said in a letter sent to the campus Thursday that it was deploying additional patrols and staffing to residential buildings.

Columbia residential staff members were instructed, in nonemergency situations, not to allow any law enforcement entry into its buildings without Columbia Public Safety present and guidance from the Office of the General Counsel.

Columbia University has become a political flash point over the past two years amid protests against Israel’s war in Gaza, high-profile ICE arrests, and criticism of the university from Trump himself.

The Trump administration ordered the cancellation of $400 million in federal grants last year after he accused the university of failing to act “in the face of persistent harassment of Jewish students.”

A letter was sent to the Columbia University trustees and the former interim president laying out conditions to restore its federal funding, which included a ban on masks on campus and comprehensive reform of its admissions “to confirm with federal law and policy.”

The university acquiesced to the demands last year to restore its grant funding. It also agreed to pay a $200 million settlement to the government to resolve allegations that it violated anti-discrimination laws.

According to the university, the agreement preserved “Columbia’s autonomy and authority over faculty hiring, admissions, and academic decision-making.”

Homeland Security agents also executed search warrants on two Columbia University residences last year, though no arrests were made at the time. The search came days after immigration authorities arrested Palestinian activist Mahmoud Khalil, a Columbia University graduate student at the time.

Khalil, a legal permanent resident, was released in June after three months in immigration detention following widespread protests and a legal battle to keep him in the U.S. Attorneys for Khalil argued that his detention was a targeted retaliation for his pro-Palestinian views and, therefore, unconstitutional.

Khalil’s status remains uncertain after an appeals court overturned a lower court ruling last month, saying he had to continue to move through the immigration court process before he could challenge whether the detention violated his rights.

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Elmina Aghayeva was detained at Columbia

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Trump’s Shields Are Down

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It’s my favorite “Star Trek” moment:

Shields are down, captain! We can’t take another hit!

In what seems like every movie or episode, whenever a federation starship is engaged in battle, its deflector shields are being raised or dropped or damaged by enemy fire to some oddly specific level (47 percent, say). It’s the stuff of high drama, when risk meets strategy to force a life-or-death decision. When shields are down, will the captain surrender, call for a shipwide evacuation, or launch an ingenious counterattack?

I do not claim full Trekkie status, but I’ve been thinking about those shields as I watch President Trump’s second term. Trump seems to have his own set of deflector shields: his cabinet secretaries and other top officials, whom he uses to absorb some of the blowback from his most contentious policies.

Kristi Noem, the secretary of homeland security, is a shield for the Trump administration’s brutal, sometimes fatal, immigration enforcement. Pam Bondi, the attorney general, is the face of the president’s efforts to exact prosecutorial vengeance upon his antagonists and to bypass such punishment for his allies. Pete Hegseth, the secretary of defense, embodies the administration’s crusade against diversity programs and its faux tough-guy persona. And Howard Lutnick, the commerce secretary, is the administration’s “tariff dealmaker in chief,” as The New Yorker put it, the implementer of the president’s stubbornly unpopular trade policies.

When the shields are at reasonable strength, they can keep taking fire, and the ship of state continues flying. But when the shields are battered and begin to malfunction, the entire enterprise is exposed. And right now, a lot of Trump’s shields seem to be faltering at once.

Cosplaying with cowboy hats and bulletproof vests, Noem oversees and defends the excesses of ICE and the border patrol, personifying all that has gone wrong with the Department of Homeland Security. The Wall Street Journal recently published an embarrassing exposé, which featured Noem feuding with senior officials and obsessing over her television appearances; and this week, The Intercept reported that a story Noem has told repeatedly about an immigrant cannibal who began eating himself on a deportation flight was fabricated, citing federal law enforcement sources. The knives are out for Noem, not only from Democrats hoping to impeach her but from within the administration itself.

At the Justice Department, Bondi has done precisely as the president has demanded — investigating or indicting his political enemies, whether they are members of Congress, prosecutors, a former F.B.I. director, or another official who served in Trump’s first administration. Yet the saga of the Epstein files hovers over her. In a spectacularly combative House hearing this month, Bondi refused to turn and face victims of Epstein’s who were present and apologize to them, and she derided members of the Judiciary Committee as “a failed politician” in one case and a “washed-up loser lawyer” in another. While the Justice Department can’t hire enough prosecutors willing to pursue her partisan agenda, Bondi melts down on live television.

velations that surrounded his nomination, by the Signal-group-chat fiasco, and by his hectoring of top military officers regarding fitness and haircuts. But more recently, his missteps have escalated. First, with the strikes against suspected drug boats in the Caribbean (including a potential war crime that Hegseth blamed on the “fog of war”), and second, with the Pentagon’s approval of the use of a laser weapon by border protection agents, which resulted in the brief shutdown of El Paso International Airport. The “warrior ethos” that Hegseth purports to represent is morphing into the incompetence that one would expect when a Fox News host is tasked with running the Pentagon.

And Lutnick, already charged with pursuing the Trump administration’s tariff policy — which 60 percent of Americans dislike — is now known to have misled the public about his connections to Epstein, which were more extensive than the secretary had previously stated. (It seems Lutnick visited Epstein’s island and did business with him after he had supposedly cut off ties.) When Representative Thomas Massie, Republican of Kentucky, calls this government “the Epstein administration,” this is the sort of thing he’s talking about.

During his first term, Trump was quick to eject top officials who displeased or embarrassed him. By this point in his first administration, the president had already moved on from the national security adviser; the F.B.I. director and deputy director; the White House chief of staff, press secretary and chief political strategist; and the secretary of health and human services. (Soon to go were his secretary of state, his top economic adviser, his secretary of veterans’ affairs, and another national security adviser.)

In the second term, by contrast, Trump has endured few major personnel losses. Mike Waltz was ousted as the national security adviser last year but received a consolation prize as the ambassador to the United Nations, while Elon Musk, who caused so much harm in his brief tenure as the head of the Department of Government Efficiency, departed the unpaid post when his time as a so-called special government employee ran out.

So, why does Trump seem less willing to dismiss top officials and advisers this time around?

Part of it may be pique. After Trump gave up on Matt Gaetz, his initial choice for attorney general, who withdrew from consideration in response to allegations of sex trafficking and drug use, the president became reluctant to buckle again. Backtracking on other cabinet choices, even dubious picks such as Hegseth for the Pentagon or Tulsi Gabbard as the director of national intelligence, might have signaled weakness, which we know this president cannot abide.

But there’s another explanation. When Trump cut loose senior officials during his first term, it was often because they espoused worldviews or priorities different from his own; in some cases, they obstructed his decisions or subscribed to norms he found useless and constraining. Remember Jeff Sessions, the attorney general whose unforgivable sin was to recuse himself from oversight of the Russia investigation, leading to the appointment of Robert Mueller as a special counsel? Or Rex Tillerson, the secretary of state who repeatedly clashed with the White House over policy? “We were not really thinking the same,” Trump explained to reporters when he pushed out Tillerson.

The offenses of Trump’s second-term cabinet members tend to be ones of loyalty or sycophancy, rarely of independent thought. Whatever damage the secretaries inflict on their country or their reputations is done on the president’s orders and on his behalf. In Trump’s first term, sacrificing cabinet members meant firing them, or pushing them to resign. In the second term, it means keeping them in the job for as long as those shields retain even marginal power.

The cabinet secretaries understand their purpose. Marco Rubio, the secretary of state (and national security adviser and onetime national archivist), is among the more respected members of the administration; he was confirmed in the post by a unanimous Senate vote, as Trump recalled in his State of the Union address this week. “People like you,” the president marveled, to Rubio, perhaps thinking of the contrast with his own weak approval ratings. But Rubio knows the deal, which Trump made clear when he mused about retaking the Panama Canal during his address to Congress last year. “Good luck, Marco,” he said. “Now we know who to blame if anything goes wrong.”

Cabinet secretaries have often taken the fall for the president they serve. Jimmy Carter’s entire cabinet and senior White House staff offered to resign in July 1979, hoping to re-energize his troubled presidency. (Carter accepted a handful of resignations and reorganized the White House, but he still lost to Ronald Reagan the next year.) And after the Republican Party suffered “a thumping” in the 2006 midterm elections, as President George W. Bush memorably put it, Donald Rumsfeld, the defense secretary overseeing the unpopular war in Iraq, quickly stepped down. (Stuff happens.)

Trump himself seems to be tiring of the cloying cabinet meetings, a staple of both terms, in which officials take turns gushing over their leader. (Personnel once meant policy; now it means flattery.) After he appeared to doze off at a recent gathering, Trump explained that it had gotten “pretty boring.” If affordability worries or violent immigration enforcement continue undercutting Trump’s standing, producing another midterm thumping for the Republicans this November, perhaps some of the cabinet secretaries will find the exits, no matter how fawningly they’ve praised Trump in public.

After all, it’s nice to have people to blame if anything goes wrong.

For the moment, though, Trump is sticking by his team, even those members who seem especially vulnerable. “Secretary Lutnick remains a very important member of President Trump’s team,” Karoline Leavitt, the White House press secretary, recently declared. “The president fully supports the secretary.” And at Homeland Security, a top spokeswoman, Tricia McLaughlin, is leaving, but not yet Noem herself, no matter that the department is so toxic on Capitol Hill that Democrats have blocked its funding.

The president can afford to dangle these battered shields by his side a little longer because he still has others at his disposal: a subservient congressional majority; a Supreme Court that, no matter its ruling on tariffs or on the deployment of National Guard troops in U.S. cities, still granted him “absolute immunity” from prosecution for official acts; and a vice president who will remain a trolling Trump loyalist as long as he thinks it will get him the Republican nomination in 2028.

For all the attention devoted to Trump’s deteriorating popularity, his public standing may not matter that much to him. Trump knows he is not going to appear on a ballot again; whatever the price for the incompetence of his cabinet or the venality of his administration, he will not be the one to pay it.

Trump’s approach to governance is entirely self-referential. His best protection may be his indifference to the plight of his party, of his potential successors, and of his fellow citizens. That shield is always at maximum strength.

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https://static01.nyt.com/images/2026/02/27/opinion/27lozada-grid/27lozada-grid-superJumbo.jpg?quality=75&auto=webpPhoto illustration by The New York Times; source photographs by Associated Press, Reuters, and Getty Images

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China is reportedly testing a new airborne wind turbine

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Hmmmm … We are falling behind the world in everything because of this Administration!

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The future of renewable energy might be in the sky. Researchers in China have reportedly tested a new, gravity-defying wind turbine system that they say could generate power from the airspace above cities.

The turbine is called the S2000 Stratosphere Airborne Wind Energy System, or SAWES. Held up by what is essentially a helium blimp, the machine reportedly generated 385 kilowatts of electricity from 2,000 meters (more than 6,500 feet) above the city of Yibin in China’s province of Sichuan, according to a recent Euronews report.

You can see it in action in the video below.

“Traditional wind turbines operate by rotating their blades when wind strikes them, thereby generating electricity,” said Weng Hanke, co-founder and chief technology officer of the turbine’s maker, Beijing Linyi Yunchuan Energy Technology, to Euronews. “This generator functions similarly, except that power generation occurs not at ground level but in the air.” As the blades spin, cables carry electricity to the ground.

Researchers reportedly conducted similar tests last September, and the machine is still a prototype. Although China is the world’s largest emitter of carbon dioxide, the country is also the global leader in renewable energy, especially wind and solar.

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https://static.scientificamerican.com/dam/m/517556dc1a360e04/original/Offshore-Wind-Power-Generation.jpg?m=1771527968.652&w=900

Wind turbines in the city of Yancheng in the Chinese province of Jiangsu. CFOTO/Future Publishing via Getty Images

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‘Fear is everywhere’: BBC reports from Mexican city turned into war zone by drug cartel feud

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Mexico’s president has praised the special forces for “bringing down” the country’s most wanted man, drug lord Nemesio Oseguera Cervantes.

Oseguera, better known as “El Mencho”, died in custody on Sunday, shortly after being captured amid a bloody firefight in Jalisco.

But as the BBC’s Quentin Sommerville found in another Mexican cartel hotspot – Culiacán in northern Sinaloa state – the vacuum left by the removal of a powerful cartel leader can trigger a surge in violence as warring factions battle for control.

Warning: This article contains graphic accounts of cartel violence, which readers may find upsetting.

“The fear is everywhere, and the fear is constant,” said paramedic Héctor Torres, 53, from the front seat of the ambulance in Culiacán.

We had just come from the scene of a shooting inside a garage in the city centre.

The owner was lying dead in his office, blood spreading across the white tiled floor. As Héctor and the other paramedic, Julio César Vega, 28, entered the premises, a woman ran in wailing.

She was the man’s wife, but there was nothing to be done. Héctor checked for vitals and then placed a paper blanket over the corpse.

For the last year and a half, the Sinaloa cartel, one of the world’s largest and most feared drug gangs, has been at war with itself, after the son of one of its leaders betrayed another.

The removal of that cartel leader, Ismael “El Mayo” Zambada, who is now in prison in the US, has wrought mayhem across Sinaloa and provides a warning of the dangers facing the country.

 
Héctor said the violence in Culiacán had never been so bad or gone on for so long. Last year, their number of call-outs increased by over 70%.

But in the week I spent with Héctor and Julio, almost every incident they responded to ended the same way, with a dead body in a building or by the side of the road, and grief-stricken relatives nearby asking for answers.

Few cartel victims survive, and nowhere is safe; schools, hospitals and even funerals have been attacked.

“Sinaloa cartel was like a family. Everyone was united in a single cartel. They were friends, they ate at the same table,” Héctor explained. “They were like brothers –parents, uncles, sisters – and suddenly they were fighting… and locked in a deadly feud,” he said.

That family business was built into a billion-dollar enterprise producing the deadly drug fentanyl and flooding US streets with opioids, which have cost tens of thousands of lives.

US President Donald Trump declared the cartel, and others, terrorist organisations, and labelled fentanyl a weapon of mass destruction. He’s threatened Mexico with direct military action if it doesn’t bring the drug and the traffickers under control.

Both Héctor and Julio were wearing body armour, 14kg of Kevlar and armour plate.

Julio said it was essential: “We don’t know if the people responsible for the attacks are still at the scene or if they completed their objective and suddenly disappeared. So we run the risk of being caught in the crossfire of an attack and getting injured.”

The sun was beginning to set as we drove back to the paramedic base, and a city that once came alive at night, would soon be deserted. Traffic was slow.

The Mexican government has sent thousands of troops to Sinaloa, and they’d set up checkpoints on most of the roads.

It turned out that when the garage owner was killed, three men were kidnapped from the premises at the same time. The heavily armed soldiers and marines were checking cars for any sign of them.

Warning: The following paragraphs contain descriptions of violence and torture which readers may find upsetting.

Kidnapping in Culiacán can be a fate worse than death.

Earlier in the week, a body had been found dumped on the pavement outside one of the main shopping malls.

From the state of the victim’s corpse, it was clear he’d been tortured. His body was intact, but the skull had been flayed and the eyes removed.

A sign was left with the corpse, in large lettering, a message from one cartel faction to another. It accused the dead man of being a traitor and came with a warning: “We are coming for the rest of you.”

Culiacán is a prosperous city, full of shopping malls, neat parks and fancy car dealerships. Outside the mall, a man in black cycling gear stopped in the rush-hour traffic to stare as the police placed the remains of the man into a body bag.

The next day, the body of another victim – mutilated in the same way – was left by the main road heading north outside of the city. When the forensic team lifted the accompanying sign, it was difficult to read; blood ran down its surface and puddled in the gravel verge.

At each new crime scene, I would meet Ernesto Martínez, who has been reporting on the violence here for 27 years. A 16-year-old boy had been shot dead in the city’s San Rafael neighbourhood; Emmanuel Alexander legs were still tangled in his bike frame as the police marked out the more than a dozen bullet casings around his body.

He’d been killed at close range by a handgun. 

Martínez explained that “there used to be more police officers, there were more soldiers, there was more security”.

“You’d find a checkpoint on every corner, and yet the homicides continued; they didn’t decrease, they remained at an average of five or six homicides a day. And the same trend continues.”

So what might end the violence? I met one of the Sinaloa factions to ask that question. Before the meeting, I was told not to bring my phone, nor any tracking devices.

They are vicious criminals, who show little remorse, and they have a simple solution to the killings. The government should step out of the way and let them murder each other – regardless of the threat to bystanders – until one faction is left standing.

They arrived at the meeting fully armed, and donned face masks for the interview, after insisting on having their identities disguised.

When I asked “Marco” (not his real name) if he had any guilt, he said: “Yes, it’s true because a lot of times innocent people die. Children die. There’s a lot of death of innocent people.”

Sitting beside him, “Miguel” (not his real name) was more ruthless: “A lot of people will keep dying because the cartel is still fighting, and it keeps getting worse. The war will continue. Nothing will calm down until there’s only one faction left.”

Reynalda Pulido’s son, Javier Ernesto, disappeared in December 2020. She’s still searching for him, and for others too – and leads the group Mothers Fighting Back.

On a chilly morning, at a petrol station not far from Culiacán, Pulido and a group of other mothers hugged each other before setting out on a search.

The women, more than a dozen, were nearly all wearing white T-shirts with the pictures and names of their missing loved ones.

They began by fixing the pictures of some of the missing to lamp posts, the sound of their tape tearing across the noise of neighbourhood dogs, which barked aggressively when they passed by homes. With them was a military escort, half a dozen heavily armed soldiers, in an armoured truck and pick-up truck with a top-mounted gunner, acting as their convoy.

In a field where buzzards were flying overhead, they used metal probes and pick axes and shovels in their search for remains. They were looking for disturbed soil, indentations in the ground, any sign of a makeshift grave. As they probed the earth, they smelt the dirt, looking for the distinctive odour of human remains.

During a break in the search, Reynalda Pulido told me that when she wakes up every day, she asks God: “Tell me why I’m here?”.

“What gives me strength is realizing that no one else is going to look for them. I realize it because no one is moving to search for the disappeared in Sinaloa. And a mother will always look for her child, no matter if it’s to the ends of the earth, she will look.”

The women had received several tip-offs that a body may have been disposed of in the field, but after hours in the midday sun, they found nothing but animal bones.

I asked Reynalda gently if she thought she would ever find her son. “It’s something I ask myself very often,” she said, wiping tears from her eyes.

“But I’ve already found my son in the 250 bodies I’ve located, and in the thirty-something people I’ve found alive. They are my children, too. And the children of all the families who come to ask me for help become my children. My son is there, in each and every one of them. All of them carry a little piece of my son.”

The root cause of Culiacán’s misery is the fentanyl trade.

In a cartel-owned basement, “Román” (not his real name), who produces the drug, tells me to follow him.

He’d just packed his latest shipment of the drug, more than half a dozen packages of tightly pressed white powder, bound for the United States.

He wore a face mask and gloves while handling the deadly bundles.

When he opened one package, it was pressed solid, the number 300 indented in the surface.

Before, they would ship pills to the US. Now, they send powder, which they believe makes it easier to avoid US Customs.

Each package weighs a kilo and is worth $20,000 (£14,800). But Román explained that, depending on the city it is sent to, it can fetch more. “If we take it to New York, it can go as high as $28,000 or $29,000. The further up it goes, the higher the price, and the greater our profit.”

He takes no responsibility, feels no shame for the business he is in. And he says that whatever the Mexican and United States governments think, the fentanyl will keep flowing.

“Even though the government has intensified the search, they’re coming after us more and getting closer, yes,” he said. “But when it comes to production, we’ve never stopped. Sometimes we do scale back because things get hot, the government gets too close. So we lay low for a few days, but once that problem passes, we either continue or move to other areas.”

The US has labelled you terrorists, we tell him. He replies, blithely: “Well, even though President Donald Trump refers to us as terrorists, I would just remind him that as long as there are consumers, we’re going to keep doing this, but that doesn’t necessarily make us terrorists. As long as people want to consume it, they are free to do so. No one is forcing them. No one forced them to start this vice, to start using this stuff.”

The Mexican government has said it is making progress in its fight against drug trafficking. It says it has cut the fentanyl supply to the US by 50%.

From Culiacán, I travelled to Mexico City. The capital’s airport was noisy with the sound of drilling and plaster being pulled from walls, preparations for World Cup 2026.

At one of her regular news conferences – held before Sunday’s killing of “El Mencho” – I asked President Claudia Sheinbaum what it would take to bring the violence in Sinaloa under control.

She blamed the internal power struggle within the Sinaloa cartel for the surge in violence in the northern state and insisted that her government was “trying to avoid harm to civilians, to the people”.

Back in Sinaloa, I’d had a final call out with the paramedics, Héctor and Julio, to another shooting downtown. As a police helicopter flew overhead, we passed through the crime scene tape to find a man on the pavement bleeding from a bullet wound to the chest. He was still breathing and screaming for help. As Héctor began treating him, Julio raced to another man around the corner, who was critically injured and wasn’t responding.

The fear that the cartel might return, even despite the presence of soldiers and marines around us, added greater urgency to the men’s work.

Both victims were patched up and rushed to a nearby hospital. They were bystanders, it turned out, caught in crossfire. But, still, the military placed an armed cordon around the hospital in case of attack. We would later learn that the men survived.

Both Héctor and Julio removed their blue rubber medical gloves, still wet with blood, and shared a cigarette. “These are the first victims we’ve found alive since November,” Héctor said.

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Members of the Sinaloa cartel have split into rival factions engaged in a deadly war, Darren Conway/BBC

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Trump Administration Live Updates: Federal Judge Finds Third-Country Deportations Unlawful

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  • Immigration: A federal judge in Boston on Wednesday found that the Trump administration’s policy of summarily deporting immigrants to nations other than their home countries is unlawful. The judge stayed his ruling for 15 days to allow the administration to appeal, but it was nonetheless a repudiation of an aggressive deportation policy that sent immigrants to countries where they have no ties, including Eswatini, Rwanda, and Ghana.

  • Surgeon General: Dr. Casey Means, the wellness influencer and entrepreneur nominated by President Trump for surgeon general, dodged questions on whether she believed vaccines cause autism at her Senate confirmation hearing on Wednesday. She also deflected questions about birth control, her finance,s and other topics while making the case that the country was suffering from an epidemic of chronic diseases.

  • State of the Union: Mr. Trump used much of his State of the Union address on Tuesday to berate Democrats, offering few new policy proposals while portraying the country as “winning” under his leadership. In the Democrats’ formal rebuttal, Gov. Abigail Spanberger accused Mr. Trump of lying about the economy, while other Democrats boycotted the speech.  

The third-country deportations ruling repudiates a key Homeland Security Department policy.

A federal judge in Boston on Wednesday found that the Trump administration’s policy of summarily deporting immigrants to so-called third countries — nations other than their countries of origin — is unlawful.

In an 81-page ruling, Judge Brian E. Murphy of the Federal District Court for the District of Massachusetts wrote that the government must first try to deport detained immigrants to their home countries — or to countries designated by an immigration judge when the immigrants were ordered removed from the country. After that process, immigration detainees must be given “meaningful notice” before being deported to another country, to allow them the opportunity to raise any fears they have that they might be persecuted or tortured there.

Senate Democrats block D.H.S. funding bill because it has no new curbs on immigration enforcement.

Senate Democrats on Tuesday blocked a spending bill to reopen the Department of Homeland Security, insisting that any such measure must include new curbs on immigration enforcement that Republicans have so far rejected.

The 50-to-45 vote all but ensured that federal funding for the department would remain halted for a second week as the stalemate between Democrats and Republicans over new restrictions on immigration agents stretches on. The legislation, which would fund the agency through September, contained modest guardrails that fell well short of Democrats’ demands. It stalled anew after failing to draw the 60 votes necessary to overcome a filibuster, with nearly all Democrats opposed, just hours before President Trump was set to address Congress. 

The nominee for surgeon general sidesteps questions about vaccines at a Senate hearing.

Dr. Casey Means, President Trump’s nominee for surgeon general, told senators on Wednesday that “anti-vaccine rhetoric has never been part of my message,” as she deflected questions about birth control, pesticides, vaccines and her finances.

Testifying before the Senate Health Committee, Dr. Means, a wellness influencer, author and leader in Health Secretary Robert F. Kennedy Jr.’s “Make America Healthy Again” movement, said Americans were suffering from an epidemic of chronic diseases linked to ultraprocessed foods, chemical exposures, and the stressed, sedentary nature of modern life.

Over more than two hours before the Senate health committee, Dr. Casey Means laid out a bleak picture of health in the United States, tying rising rates of chronic diseases to the foods Americans eat, how little we move, the medications we take and the toxic chemicals around us. While Means called for a “great national healing” during her confirmation hearing for surgeon general, she repeatedly dodged questions on vaccines, including from Senator Bill Cassidy of Louisiana, a Republican who is a doctor and a proponent of vaccines.

Means said that she believed vaccines were life-saving and important but also that parents and patients should have autonomy and rely on thorough discussions with their doctors. She also faced numerous questions about the supplements and wellness products she has previously promoted in her newsletter.

The Senate’s confirmation hearing for Dr. Casey Means, President Trump’s nominee for surgeon general, has ended. Dr. Casey Means did not answer directly when Senator Bill Cassidy, Republican of Lousiana, asked if universal hepatitis B vaccination was an important goal. She said the vaccine was life-saving but that parents should have “autonomy.” She said children should be immunized “at some point in their youth.” Cassidy, a medical doctor and liver specialist, has previously spoken out strongly in support of the vaccine.Dr. Means said she had “significant concerns” about pesticides like glyphosate, and called for them to be studied more robustly. She has previously called moving away from industrial agriculture practices that use toxic pesticides the single most important strategy for solving health and environmental issues. She has also called the use of pesticides a “slow-motion extinction event.”Senator Lisa Murkowski, Republican of Alaska, pressed Means about past comments she had made on the hepatitis B vaccine for newborns. Means said the vaccine was “effective” and “very important,” but that parents should make a shared decision with doctors.

Democrats counter Trump after his combative State of the Union speech.

President Trump used much of his nearly two-hour State of the Union address on Tuesday night to berate and taunt Democrats, who responded by accusing the president of lying about the economy and ignoring voters’ concerns.

In his remarks, Mr. Trump introduced few new policies and instead appeared to relish the theatrics of the moment. He attacked Democrats as “crazy” for not standing for or applauding his priorities, especially on crime, immigration and the economy.

Ilhan Omar condemns arrest of her guest at State of the Union.

Representative Ilhan Omar on Wednesday condemned the arrest of a guest she brought to the State of the Union, saying that being charged with a crime for standing up in the gallery during the president’s address “sends a chilling message about the state of our democracy.”

Aliya Rahman, a U.S. citizen who was dragged from her vehicle after an ICE agent shattered its window during President Trump’s immigration crackdown in Minneapolis, attended the president’s speech on Tuesday night at the invitation of Ms. Omar. As Mr. Trump was speaking, Ms. Rahman was seen being escorted from the gallery above the House floor by Capitol Police officers. She could be heard shouting for someone to call Ms. Omar, and that all she had done was stand up.

Trump’s speech gets a mixed reaction around the world.

President Trump’s State of the Union address on Tuesday has prompted a variety of reactions in the global news media.

Canada’s public broadcaster called it a “relatively focused” speech by the president’s standards, with “one angry detour” about immigration. The British Broadcasting Corporation said it was “made-for-the-cameras” moment, while The Guardian deemed it Mr. Trump’s “most inconsequential” address yet. The South China Morning Post noticed he did not mention Beijing.

Representative Ilhan Omar, Democrat of Minnesota, released a statement condemning the arrest of one of her guests at last night’s State of the Union speech: Aliya Rahman, a U.S. citizen who had been dragged from her car after an ICE agent shattered her car’s window during the immigration crackdown in Minneapolis. In an interview with “Democracy Now,” Rahman said that the sergeant of arms told her she was arrested because she had stood up during the speech.

Rahman “stood up silently in the gallery during the president’s speech for a short period of time, part of which other guests were also standing,” Omar said. “For that, she was forcibly removed, despite warning officers about her injured shoulders and ultimately charged with ‘Unlawful Conduct.’”

“The heavy-handed response to a peaceful guest sends a chilling message about the state of our democracy,” Omar said, calling for a full explanation.

President Trump insulted and criticized Representatives Ilhan Omar and Rashida Tlaib, two Muslim Democrats who heckled him during his State of the Union address, suggesting in a post on Truth Social on Wednesday that that America “should send them back from where they came.”

Trump has a history of making such nativist attacks, which lawmakers have long criticized as deploying racist tropes, against both women, left-leaning lawmakers, who were the first two Muslim women ever elected to Congress. Tlaib, the daughter of Palestinian immigrants, was born in Detroit. Omar, a frequent target of the president, is from Somalia. Both are American citizens.

Seven voters react to Trump’s address.

During President Trump’s State of the Union address, many medals were given out. There was taunting of Democrats, a few of whom shouted right back.

But in a midterm election year, with his polls numbers slipping, Mr. Trump spent much of the speech trying to make the case that his second term was “a turnaround for the ages.”

Vance says Trump administration will withhold over $250 million in Medicaid funds from Minnesota.

Trump administration officials announced on Wednesday that the federal government would withhold $259 million in Medicaid funds to Minnesota, the latest effort by the federal government to pull funding from Democratic-led states as President Trump rails against a major welfare fraud scandal there.

Federal judges have blocked most of the Trump administration’s efforts to claw back funds from states like Minnesota, New York, California, Illinois and Colorado. The states have decried the cuts as politically motivated, adding that they would harm hundreds of thousands of people. The Trump administration has pointed to allegations of fraud to justify the cuts.

Patel ousts F.B.I. personnel tied to the inquiry into Trump’s retention of classified records.

About 10 F.B.I. employees, some veteran agents, were dismissed this week for their work on the investigation into President Trump’s retention of classified documents at Mar-a-Lago, his residence in Florida, according to five people with knowledge of the move.

The firings are part of a rolling barrage of retribution aimed at those who worked on the two federal prosecutions of Mr. Trump after his first term in office. They came hours after Kash Patel, the F.B.I. director, told Reuters that as part of the documents inquiry, the bureau had subpoenaed phone metadata for himself and Susie Wiles, currently the White House chief of staff.

A federal prosecutor found to be in civil contempt of court by a judge in Minnesota is now appealing that ruling, according to court filings. Matthew Isihara, a military judge advocate on temporary assignment to the Justice Department, was found in contempt by Judge Laura M. Provinzino last week after D.H.S. released an immigration detainee hundreds of miles away from home, and without his identification papers, contrary to the judge’s order. Because his papers were returned promptly by FedEx after the contempt ruling, Isihara was able to avoid a $500-a-day fine, but the legal dispute over his conduct will now continue. The notice filed Wednesday with the U.S. Court of Appeals for the Eighth Circuit says Isihara is appealing “in his individual capacity,” and is signed by Daniel N. Rosen, the district’s U.S. attorney. The appeal comes as dozens of judges across the country threaten to hold administration lawyers in contempt for ignoring their orders and missing filing deadlines in cases where immigrants are challenging the legality of their detention. 

About 10 F.B.I. employees, some of them veteran agents, have been dismissed in connection with their work on the federal investigation into President Trump’s improper retention of classified documents at Mar-a-Lago, his residence and resort in Florida, according to three people with knowledge of the matter. The dismissals came on the same day Kash Patel, the F.B.I. director, told Reuters that the F.B.I. had subpoenaed phone metadata for himself and Susie Wiles, currently the White House chief of staff, when they were private citizens in 2022 and 2023 as part of the documents investigation.

Vice President JD Vance announced that the Trump administration would withhold $259 million in Medicaid funds to Minnesota, the latest effort by the federal government to pull funding from Democratic states. Federal judges have blocked most of those actions, including two pots of funds of more than $10 billion distributed by the Department of Health and Human Services.

Like the previous safety net cuts, administration officials justified the withheld funds by pointing to a major welfare fraud scandal that has rocked Minnesota. President Trump has alleged, without evidence, that similar large fraud schemes are playing out elsewhere in Minnesota and other Democratic states. The president has also, improbably, claimed that there is so much fraud that he would be able to balance the federal budget once he eliminated such waste — a mathematically impossible feat, given the amount of funding involved compared with the size of the deficit.

The Senate voted along party lines to fill the seat of an air safety official ousted by Trump.

The Senate on Wednesday voted along party lines to confirm John DeLeeuw to the National Transportation Safety Board, filling an opening that President Trump created when he fired the board’s vice chair, who is suing to get his job back.

The debate over the selection of Mr. DeLeeuw, a longtime aviator and executive for American Airlines, did not center on his qualifications. The 50-to-45 vote, in which all Republicans voted to confirm, served as more of a referendum on whether Mr. Trump has power to fire Senate-confirmed federal officials — a question being considered by the Supreme Court.

Senator Tim Kaine, Democrat of Virginia, said Wednesday that he would most likely force a vote next week on a measure to curb President Trump’s power to order an attack on Iran. “The president made no real case last night as to why we should be in a war with Iran,” Kaine said on Capitol Hill. “We should not send our sons and daughters into another war in the Middle East.”

Kaine conceded that the Republican majority could kill the bill, as they did with a similar resolution on Venezuela last month. But with the president ordering a build up of U.S. military force in the region, he said he intended to make sure “everybody is going to be on the record.”

President Volodymyr Zelensky of Ukraine said he spoke with Trump over the phone on Wednesday, along with Steve Witkoff and Jared Kushner, about the peace talks set to take place in Geneva on Thursday. Zelensky said he thanked Trump for a program that allows European allies to buy U.S. air defense missiles for Ukraine, which Trump touted during his State of the Union address on Tuesday. “This winter has been the most difficult one for Ukraine, but the missiles for air defense systems that we purchase from the U.S. are helping us get through all these challenges and protect lives,” Zelensky said in a statement. Vice President JD Vance told Fox News on Wednesday that Iran should take President Trump’s threats to use military action “seriously,” saying the president had shown a “willingness” to use force if diplomatic efforts fail to stop Iran from acquiring nuclear weapons. His comment echoed President Trump’s State of the Union address, in which he said that his “preference” was to take the path of diplomacy but did not explain why he had amassed the largest amount of military firepower in the Middle East since the United States invaded Iraq in 2003. Negotiators for both the United States and Iran are set to hold indirect talks in Geneva on the United States imposed new sanctions on Wednesday on more than 30 entities, individuals, and vessels that it said were linked to Iran’s weapons procurement networks and the shadow fleet surreptitiously transporting Iranian oil to foreign markets. The Treasury Department will continue to apply “maximum pressure on Iran to target the regime’s weapons capabilities and support for terrorism,” Secretary Scott Bessent said in a statement.

President Claudia Sheinbaum of Mexico said on Wednesday that she had an eight-minute phone call with President Trump on Monday after a military operation in the state of Jalisco during which the cartel leader Nemesio Oseguera Cervantes, known as El Mencho, was killed. The kiling unleashed retaliatory violence by the cartel in several states.

She said that Trump asked what was happening in Mexico. “I told him how the operation had gone, that we had received intelligence support from the U.S. government, that the coordination was going very well, and that was it,” Sheinbaum said. This contrasts with Trump’s remarks on Tuesday night during his State of the Union address, when he appeared to take credit for the operation.

To deal with rising electric bills, Trump says tech companies will pay.

In a nod to voter frustration over rising electricity prices, President Trump on Tuesday said he was negotiating pledges from major tech companies to pay a greater share of the energy costs associated with new data centers.

Silicon Valley is spending hundreds of billions of dollars to build power-hungry data centers for artificial intelligence as demand for electricity is increasing across the United States. That has led to widespread fears that the A.I. boom could cause utility bills to spike for ordinary households.

The United States sent a group of F-22 Raptor jets to Israel on Tuesday, a U.S. official and a person familiar with the deployment said. The move continued the U.S. military buildup in the Middle East and came two days before the next round of negotiations with Iran about its nuclear program was expected.

Flight tracking data and videos show what appears to be the first known deployment of this type of aircraft, one of the most advanced U.S. fighter jets, during the escalating tensions with Iran. Videos and photos captured by plane spotters show a dozen F-22s taking off from their temporary station in Britain.

The Latest on the Trump Administration


  • State of the Union: In the longest such address in U.S. history, President Trump cast Democrats as villains and insisted he had overseen a “turnaround for the ages,” even as voters lost confidence in his handling of the economy. Gov. Abigail Spanberger of Virginia gave the Democratic rebuttal. Here are six takeaways from the night.

  • Surgeon General Nominee: Dr. Casey Means told senators in her confirmation hearing that “anti-vaccine rhetoric has never been part of my message,” as she deflected questions about birth control, pesticides, vaccines, and her finances.

  • Bureau of Land Management: An unusual coalition of hunters, veterans, and environmental activists is opposing Steve Pearce, Trump’s choice to lead the

  • bureau, citing concerns about actions he had taken as a lawmaker to try to sell public lands to private interests.

  • Mideast Military Buildup: The United States sent a group of F-22 Raptor jets to Israel, a U.S. official and a person familiar with the deployment said, a continuation buildup of forces in the region that came two days before another round of negotiations with Iran.

  • Kash Patel: The F.B.I. director’s trip to Italy — culminating in a celebratory beer swig with the U.S. hockey team at the Milan Olympics — included several hours of work meetings, a handful of meet-and-greets, hours of downtime, private meals, and “cultural activities,” according to an internal schedule obtained by The Times. The taxpayer-funded visit reignited the firestorm over use of government resources.

  • Homeland Security Funding: Senate Democrats blocked a spending bill to reopen the Department of Homeland Security, insisting that any such measure must include new curbs on immigration enforcement that Republicans have so far rejected. The vote all but ensured that federal funding for the department would remain halted for a second week.

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https://static01.nyt.com/images/2025/03/21/multimedia/live-blog-20260225-trump-news-header-1/live-blog-20260225-trump-news-header-1-jumbo-v3.jpg?quality=75&auto=webpA group of Middle Eastern and Asian migrants deported by the U.S. government at a shelter in Panama last year. Credit…Nathalia Angarita for The New York Times

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Alzheimer’s blood tests predict what age people will be when the disease may cause symptoms, study finds

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Blood tests that detect a protein involved in Alzheimer’s disease could help predict the age at which the disease may strike people long before they develop symptoms, according to a new study. But questions remain about the accuracy and uncertainty of these tests, and experts caution that the assays aren’t ready for prime time.

“While the results here are encouraging, they are not yet at the level of having significant clinical benefit for individual patients,” says Corey Bolton, a clinical neuropsychologist and an assistant professor of medicine at Vanderbilt University Medical Center, who was not involved in the new study. “Alzheimer’s disease is a complex condition with numerous intersecting risk and resilience factors that vary from person to person. These factors can have a large influence in the age of symptom onset and the rate of clinical decline.”

The study included more than 600 people aged 62 to 78 who were not cognitively impaired. They had blood tests to detect a protein called p-tau217, which accumulates in the brains of people with Alzheimer’s. The researchers then used a model based on the tests to predict the age of onset of the disease in people with no cognitive impairment, with three to four years of uncertainty.

“A key innovation was estimating when they’re going to develop symptoms,” says Suzanne Schindler, an associate professor of neurology at the Washington University School of Medicine in St. Louis, who co-authored the study. The research was published on Thursday in Nature Medicine. Several of the study authors have consulted for or received funding from companies that make these Alzheimer’s blood tests. Schindler says she provides unpaid consulting to diagnostic companies.

More than seven million Americans are living with Alzheimer’s disease, and there is no cure. The neurodegenerative condition is associated with the buildup of plaques of amyloid protein and tangles of tau protein in the brain, which can develop for a decade or more before visible symptoms such as memory loss or confusion arise.

Blood tests are increasingly used to detect biological signs of the disease. They are much cheaper and easier to administer than traditional diagnostics such as spinal taps or positron-emission tomography (PET) scans. Two tests are approved for use in the U.S. in people with Alzheimer’s symptoms—Lumipulse (made by Fujirebio) and Elecsys (made by Roche Diagnostics).

But these tests may not always accurately predict who will and won’t develop Alzheimer’s, experts say. And the medical consensus is that they should not be taken by people who do not have symptoms of cognitive decline.

Detecting Alzheimer’s before symptoms show up, however, may be crucial to treating it: although there is no cure for the condition, two drugs have been approved that can slow the rate of progression in some people when the disease is caught early. And there are clinical trials of these drugs underway to determine whether treatment could head off the disease in people who have biological signs of the disease but no symptoms. The results are expected in the next few years.

In the new study, Schindler and her colleagues tested how well a blood test for p-tau217 could predict the age at which people who had the protein would develop symptoms of the disease. They found that these blood, or plasma, “clocks” could predict how likely and when people would develop symptoms of the disease. Interestingly, the older a person was, the sooner symptoms would appear.

“So, for example, if you have a positive blood test when you’re 60, it may take 20 years before you develop symptoms—versus, if you don’t have a positive blood test until you’re 80, it may take only 10 years,” Schindler says.

Of course, the tests are not foolproof. It’s important to note that the researchers are “not recommending this for people who are asymptomatic,” says Zaldy Tan, a memory and aging specialist at the Cedars-Sinai Medical Center in Los Angeles. And a three- to four-year error margin on either side of diagnosis is “a big window,” he notes, especially if you’re using the knowledge to make decisions about retirement plans or finances.

“Other medical conditions, such as chronic kidney disease and obesity, seem to have a large impact on the circulating levels of these proteins and can greatly influence results, leading to false positives or false negatives,” Bolton says. This study used a type of test that limits the effect of these conditions, he says, but “there are still many unanswered questions about how these blood tests perform in diverse populations.”

Despite their limits, however, the tests are still valuable for diagnosis and planning treatment, Bolton says. People found to be at greater risk of developing the disease could still benefit from interventions such as exercise, a healthy diet and cognitive or social stimulation.

Nathaniel Chin, a geriatrician and medical director at the Wisconsin Alzheimer’s Disease Research Center in Madison, who was not involved in the study, is “impressed and excited” by its results. He hopes researchers will replicate the findings in other populations.

The study was funded by a public-private partnership through the Foundation for the National Institutes of Health Biomarkers Consortium. Schindler notes that the study data are publicly available and that anyone can download and analyze them.

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OpenAI and Google Take Steps to Avoid Abusive AI Imagery After Grok Scandal

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2026 started with a horrifying example of generative AI’s potential for abuse. Grok, the AI tool from Elon Musk’s xAI, was used to undress or nudify pictures of people shared on X (formerly Twitter) at an alarming rate. Grok made 3 million sexualized images over a span of 11 days in January, with approximately 23,000 of those containing images of children, according to a study from the Center for Countering Digital Hate.

Now, competitors like OpenAI and Google are stepping up their security to avoid being the next Grok.

Advocates and safety researchers have long been concerned about AI’s ability to create abusive and illegal content. The creation and sharing of nonconsensual intimate imagery, sometimes referred to as revenge porn, was a big problem before AI. Generative AI only makes it quicker, easier, and cheaper for anyone to target and victimize people. 

2026 started with a horrifying example of generative AI’s potential for abuse. Grok, the AI tool from Elon Musk’s xAI, was used to undress or nudify pictures of people shared on X (formerly Twitter) at an alarming rate. Grok made 3 million sexualized images over a span of 11 days in January, with approximately 23,000 of those containing images of children, according to a study from the Center for Countering Digital Hate.

Now, competitors like OpenAI and Google are stepping up their security to avoid being the next Grok.

Advocates and safety researchers have long been concerned about AI’s ability to create abusive and illegal content. The creation and sharing of nonconsensual intimate imagery, sometimes referred to as revenge porn, was a big problem before AI. Generative AI only makes it quicker, easier, and cheaper for anyone to target and victimize people. 

On Jan. 14, two weeks into the scandal, X’s Safety account confirmed in a post that it would pause Grok’s ability to edit images on the social media app. Grok’s image-generation abilities are still available to paying subscribers in its standalone app and website. X did not respond to multiple requests for comment.

Most major companies have safeguards in place to prevent the kind of wide-scale abuse that we saw was possible with Grok. But cybersecurity is never a solid metal wall of protection; it’s a brick wall that’s constantly undergoing repairs. Here’s how OpenAI and Google have tried to beef up their safety protections to circumvent Grok-like failures.

Read More: AI Slop Is Destroying the Internet. These Are the People Fighting to Save It

OpenAI fixes image generation vulnerabilities

At a base level, all AI companies have policies prohibiting the creation of illegal imagery, like child sexual abuse material, also known as CSAM. Many tech companies have guardrails to prevent the creation of intimate imagery altogether. Grok is the exception, with “spicy” modes for image and video.

Still, anyone intent on creating nonconsensual intimate imagery can try to trick AI models into doing so.

Researchers from Mindgard, a cybersecurity company focused on AI, found a vulnerability in ChatGPT that allowed people to circumvent its guardrails and make intimate images. They used a tactic called “adversarial prompting,” where testers try to poke holes in an AI with specifically crafted instructions. In this case, it was tricking the chatbot’s memory with custom prompts, then copying the nudified style onto images of well-known people.

Mindgard alerted OpenAI of its findings in early February, and the ChatGPT developer confirmed on Feb. 10 — before Mindgard went public with its report — that it had fixed the problem.

“We’re grateful to the researchers who shared their findings,” an OpenAI spokesperson said to CNET and Mindgard. “We moved quickly to fix a bug that allowed the model to generate these images. We value this kind of collaboration and remain focused on strengthening safeguards to keep users safe.”

This process is how cybersecurity often works. Outside red-team researchers like Mindgard test software for weaknesses or workarounds, mimicking strategies that bad actors might use. When they identify security gaps, they alert the software provider so fixes can be deployed.

“Assuming motivated users will not attempt to bypass safeguards is a strategic miscalculation. Attackers iterate. Guardrails must assume persistence,” Mindgard wrote in a blog post.

While tech companies boast about how you can use their AI for any purpose, they also need to make a strong promise that they can prevent AI from being used to enact abuse. For AI image generation, that means having a strong repertoire of prompts that will be refused and kicked back to users. 

When OpenAI launched its Sora 2 video model, it promised to be more conservative with its content moderation for this very reason. But it’s important to ensure its moderation practices are consistently effective, not just at a product’s launch. It makes AI safety testing an ongoing process for cybersecurity researchers and AI developers alike.

Google upgrades Search reporting

For its part, Google is taking steps to ensure abusive images aren’t spread as easily. The tech giant simplified its process for requesting the removal of explicit images from Google Search. You can click the three dots in the upper right corner of an image, click report and then tell Google you want the photo removed because it “shows a sexual image of me.” The new changes also let you select multiple images at once and track your reports more easily.

“We hope that this new removal process reduces the burden that victims of nonconsensual explicit imagery face,” the company said in a blog post.

When asked about any further steps the company is taking to prevent AI-enabled abuse, Google pointed CNET to its generative AI prohibited use policy. Google’s policy, like many other tech companies’ fine print, outlaws using AI for illegal or potentially abusive activities, such as creating intimate imagery.

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AI safety is an ongoing challenge. ismagilov/iStock/Getty Images

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State of the Union Live Updates: Trump Is Set to Speak at a Pivotal Moment

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Bruised by a Supreme Court setback and falling approval ratings, the president has an opportunity to change the narrative ahead.

Here’s the latest.

President Trump, reeling from a major setback on his sweeping tariffs at the Supreme Court and facing the lowest approval ratings of his second term, will deliver his State of the Union address on Tuesday at a pivotal moment in his presidency.

He is expected to highlight what he said was a lengthy list of achievements. But polls show that Americans, by a wide margin, now disapprove of him on what were once his winning issues: the economy and immigration. Republicans are now in danger of losing the House in the upcoming midterm elections, a development that would threaten much of Mr. Trump’s second-term agenda.

Add Representative Alexandria Ocasio-Cortez, Democrat of New York, to the list of prominent Democrats who are boycotting Trump’s speech. The list so far includes some 40 lawmakers. We’re still waiting to hear where others, like Nancy Pelosi, the former House speaker, land. Notably, the No. 2 Democrat in the House, Katherine Clark of Massachusetts, is not coming. Representative Al Green, the septuagenarian Texas Democrat who last year was ejected from the chamber during Trump’s speech for shouting and waving his cane, is in the chamber with a homemade cardboard sign that says “Al Green.” His outburst last year, which Republicans eventually censured him for, was largely viewed with frustration by Democrats, who thought it was a childish form of protest.

How The Times reports on the State of the Union.

Tonight is somewhat of a political Super Bowl: President Trump will deliver his State of the Union address to the nation, a tradition that dates to 1790.

“It’s an important moment to see where the president is focused and how he is being received,” said Julie Hirschfeld Davis, The New York Times’s congressional editor, who is helping coordinate coverage of the speech.

Biden laid out the stakes of Russia’s invasion of Ukraine four years ago.

Four years ago, Russia poured over the border into Ukraine, igniting the biggest war in the heart of Europe since the end of World War II. The invasion that began on Feb. 24, 2022, shattered the notion that the world order that followed had banished the days when powerful nations simply took over their weaker neighbors.

Days later, President Joseph R. Biden Jr. laid out the stakes during a State of the Union address and received towering applause, even from Republicans who disliked him and despised his agenda. After all, vowing to support nascent democracies was still in favor in Washington, an idea that crossed party lines. 

More than a dozen Epstein victims will attend the speech as lawmakers’ invited guests.

Over a dozen lawmakers are bringing survivors of Jeffrey Epstein’s abuse to President Trump’s State of the Union address on Tuesday night, a statement against the administration’s handling of documents related to the convicted sex offender.

Lawmakers for many years have invited guests to the annual speech as a way of sending pointed messages to the president. A number of Democrats have said they will boycott the speech and attend a rally on the National Mall near the Capitol.

U.S. men’s hockey team arrives for the State of the Union, but the women stay away.

Fresh from winning a gold medal, members of the U.S. men’s hockey team arrived at the White House on Tuesday afternoon, two days after President Trump invited them to visit the residence and then attend his State of the Union speech on Capitol Hill.

The president had excitedly extended the invitation on Sunday by speakerphone, when he placed a call to the equally jazzed F.B.I. director, Kash Patel. Mr. Patel was at the Winter Olympics in Italy, celebrating and spraying beer in the locker room with the men’s team.

More than a dozen Epstein victims will attend the speech as lawmakers’ invited guests.

Over a dozen lawmakers are bringing survivors of Jeffrey Epstein’s abuse to President Trump’s State of the Union address on Tuesday night, a statement against the administration’s handling of documents related to the convicted sex offender.

Lawmakers for many years have invited guests to the annual speech as a way of sending pointed messages to the president. A number of Democrats have said they will boycott the speech and attend a rally on the National Mall near the Capitol.

U.S. men’s hockey team arrives for the State of the Union, but the women stay away.

Fresh from winning a gold medal, members of the U.S. men’s hockey team arrived at the White House on Tuesday afternoon, two days after President Trump invited them to visit the residence and then attend his State of the Union speech on Capitol Hill.

The president had excitedly extended the invitation on Sunday by speakerphone, when he placed a call to the equally jazzed F.B.I. director, Kash Patel. Mr. Patel was at the Winter Olympics in Italy, celebrating and spraying beer in the locker room with the men’s team.

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The Capitol

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Click the link below for the complete article:

https://www.nytimes.com

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How does type 1 diabetes actually work?

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Have you ever thought about how your body turns food into energy? Or just how carefully it has to manage that process?

When we eat, the glucose from our food gets stored in the liver as glycogen. And based on our body’s needs, the liver will convert that glycogen back into glucose so that it can travel through the blood and get to our cells, which turn that glucose into energy.

Meanwhile, our pancreas produces a hormone called insulin whose job is to go into the blood and tell our cells to take in that glucose. That also makes insulin a regulator of our body’s blood sugar levels, preventing the complications that can happen when our levels are too high or too low.

When the pancreas stops producing insulin, glucose doesn’t enter our cells. Instead, it accumulates in the bloodstream. In some people, the pancreas stops making insulin altogether. This condition is known as type 1 diabetes.

While the exact cause is mysterious, we know the disease happens because immune cells target and attack insulin-producing cells in the pancreas called beta cells. As those cells get destroyed, the body stops producing insulin and loses the key regulator of blood sugar levels. That in turn can drive a number of symptoms, including fatigue and weakness.

Over the 20th and 21st centuries, scientists have developed technologies that have made type 1 diabetes treatable. These include meters to check blood glucose levels and pumps that give small doses of insulin. And with advances in construction and software, these tools have become smaller and more portable. Despite these advances, scientists are still pursuing a cure for type 1 diabetes.

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1 . Click the link below, 2 . Click ‘How does type 1 diabetes actually work’, 3 . click play button.

https://www.scientificamerican.com/video/how-does-type-1-diabetes-actually-work/

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