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Missed News 497
February 19, 2021
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Missed News 496
February 18, 2021
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Missed News 495
February 17, 2021
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The Epigenetic Secrets Behind Dopamine, Drug Addiction and Depression
February 16, 2021
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As I opened my copy of Science at home one night, an unfamiliar word in the title of a new study caught my eye: dopaminylation. The term refers to the brain chemical dopamine’s ability, in addition to transmitting signals across synapses, to enter a cell’s nucleus and control specific genes. As I read the paper, I realized that it completely upends our understanding of genetics and drug addiction. The intense craving for addictive drugs like alcohol and cocaine may be caused by dopamine controlling genes that alter the brain circuitry underlying addiction. Intriguingly, the results also suggest an answer to why drugs that treat major depression must typically be taken for weeks before they’re effective. I was shocked by the dramatic discovery, but to really understand it, I first had to unlearn some things.
“Half of what you learned in college is wrong,” my biology professor, David Lange, once said. “Problem is, we don’t know which half.” How right he was. I was taught to scoff at Jean-Baptiste Lamarck and his theory that traits acquired through life experience could be passed on to the next generation. The silly traditional example is the mama giraffe stretching her neck to reach food high in trees, resulting in baby giraffes with extra-long necks. Then biologists discovered we really can inherit traits our parents acquired in life, without any change to the DNA sequence of our genes. It’s all thanks to a process called epigenetics — a form of gene expression that can be inherited but isn’t actually part of the genetic code. This is where it turns out that brain chemicals like dopamine play a role.
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James O’Brien for Quanta Magazine
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Missed News 494
February 16, 2021
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Missed News 493
February 15, 2021
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How Many Americans Are About to Die?
February 13, 2021
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The United States has made huge advances in fighting the coronavirus. The astonishingly high death rates the country saw during the spring have fallen, and Americans are much more likely now than they were then to survive a COVID-19 hospitalization. New treatments have, in some cases, helped speed recovery—President Donald Trump has trumpeted his own bout with the virus as proof that there is a “cure” for the illness. (There is not.) These developments have given Americans the impression that no matter how high cases surge, deaths might not reach the heights of the spring.
But the truth is grimmer. The story people want to believe about how much treatments have improved in recent months does not hold up to quantitative scrutiny.
The U.S. health-care system has not reduced the deadliness of the coronavirus since July, according to a new estimate by a prominent COVID-19 researcher, which accounts for the lags in public reporting of cases and deaths. Instead, the virus has, with ruthless regularity, killed at least 1.5 percent of all Americans diagnosed with COVID-19 over the past four months.
This rate is a major improvement, down more than tenfold from the earliest days of the pandemic when deaths were high and the extreme limits on coronavirus testing held down the number of diagnosed cases. But in this new phase of the pandemic, when testing is more widely available and a much higher proportion of cases are diagnosed, to begin with, it is also terrible, terrible news.
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Shutterstock / Paul Spella / The Atlantic.
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Coronavirus is evolving. Whether it gets deadlier or not may depend on us
February 13, 2021
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Missed News 489
February 10, 2021
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Missed News 488
February 9, 2021
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James' World 2 