James' World 2

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I always wanted to understand life. What moves us? What allows us to heal and thrive? And what goes wrong when we get sick or when we eventually stop breathing and die? My search for answers to these stupendously ambitious questions led me, it now seems inexorably, to mitochondria.

In biology classes from high school through university, I learned that mitochondria are little objects that reside within each cell and serve as “powerhouses,” combining oxygen and food to yield energy for the body. This idea of mitochondria being little batteries with a built-in charger, about as interesting as the one in my phone, left me unprepared for the vital reality of these organelles when I first saw them under a microscope in 2011. They were luminous because of a glowing dye I had put in them, and they were dynamic—constantly moving, stretching, morphing, touching one another. They were beautiful. That night, a graduate student alone in a dark laboratory in Newcastle upon Tyne in England, I became a mitochondriac: hooked on mitochondria.

A profound insight by biologist Lynn Margulis helped me make some sense of what I was seeing. She postulated in 1967 that mitochondria descend from a bacterium that was engulfed by a larger ancestral cell about 1.5 billion years ago. Instead of consuming this tidbit, the larger cell let it continue living within. Margulis called this event endosymbiosis, which means, roughly, “living or working together from the inside.” The host cell had no energy source that used oxygen, which, thanks to plants, was already abundant in the atmosphere; mitochondria filled this gap. The unlikely union allowed cells to communicate and cooperate and let their awareness expand beyond their own boundaries, enabling a more complex future in the form of multicellular animals. Mitochondria made cells social, binding them in a contract whereby the survival of each cell depends on every other one, and thus made us possible.

Amazingly, my co-workers and I have discovered that mitochondria are themselves social beings. At least, they foreshadow sociality. Like the bacterium they descended from, they have a life cycle: old ones die out, and new ones are born out of existing ones. Communities of these organelles live within each cell, usually clustered around the nucleus. Mitochondria communicate, both within their own cells and among other cells, reaching out to support one another in times of need and generally helping the community flourish. They produce the heat that keeps our bodies warm. They receive signals about aspects of the environment in which we live, such as air pollution levels and stress triggers, and then integrate this information and emit signals such as molecules that regulate processes within the cell and, indeed, throughout the body.

When our mitochondria thrive, so do we. When they malfunction—when, for instance, their ability to change energy into forms required for biochemical reactions is impaired—we may experience conditions as diverse as diabetes, cancer, autism, and neurodegenerative disorders. And as mitochondria accumulate defects over a lifetime of stress and other insults, they contribute to aging and, ultimately, death. To understand these processes—to see how to sustain physical and mental health—it helps to understand how energy moves through our bodies and minds. That requires a deeper look into mitochondria and their social lives.

Long before I got my first glimpse of mitochondria, I had boned up on the basics of their structure and biology. We inherit our mitochondria from our mother—from the egg cell, to be precise. Mitochondria have their own DNA, which consists of only 37 genes, compared with the thousands of genes in the spiraling chromosomes inside the cell nucleus. This ring of mitochondrial DNA, or mtDNA, is sheltered within two membranes. The outer shell, shaped like the skin of a sausage, encases the mitochondrion and selectively allows molecules to enter or exit. The inner membrane is made of densely packed proteins and has many folds, called cristae, which serve as a site for chemical reactions, much like the plates suspended inside a battery.

Rather than being like battery chargers, mitochondria are more like the motherboard of the cell.

In the 1960s, British biochemists Peter Mitchell and Jennifer Moyle discovered how electrons derived from carbon in food combine with oxygen in the cristae, releasing a spark of energy that is captured as a gradient in electrical voltage across the membrane. This voltage provides the driving force for all processes in the body and brain, from warming to manufacturing molecules to thinking. Mitochondria also produce a molecule called adenosine triphosphate, which serves as a portable unit of energy that powers hundreds of biochemical reactions within each cell.

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Jennifer N.R. Smith

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U.S. Court of International Trade in New York City, August 22, 2022.Getty Images

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Hail the size of grapefruit shattered car windows in Johnson City, Texas. In June, 2024, a storm chaser found a hailstone almost as big as a pineapple. Even larger hailstones have been documented in South Dakota, Kansas, and Nebraska. Hail has damaged airplanes and even crashed through the roofs of houses.

How do hailstones get so large, and are hailstorms getting worse?

As an atmospheric scientist, I study and teach about extreme weather and its risks. Here’s how hail forms, how hailstorms may be changing, and some tips for staying safe.

How does hail get so big?

Hail begins as tiny crystals of ice that are swept into a thunderstorm’s updraft. As these ice embryos collide with supercooled water – liquid water that has a temperature below freezing – the water freezes around each embryo, causing the embryo to grow.

Supercooled water freezes at different rates, depending on the temperature of the hailstone surface, leaving layers of clear or cloudy ice as the hailstone moves around inside a thunderstorm. If you cut open a large hailstone, you can see those layers, similar to tree rings.

The path a hailstone takes through a thunderstorm cloud, and the time it spends collecting supercooled water, dictates how large it can grow.

Rotating, long-lived, severe thunderstorms called supercells tend to produce the largest hail. In supercells, hailstones can be suspended for 10-15 minutes or more in strong thunderstorm updrafts, where there is ample supercooled water, before falling out of the storm due to their weight or moving out of the updraft.

Hail is most common during spring and summer when a few key ingredients are present: warm, humid air near the surface; an unstable air mass in the middle troposphere; winds strongly changing with height; and thunderstorms triggered by a weather system.

Larger hail, more damage

Hailstorms can be destructive, particularly for farms, where barrages of even small hail can beat down crops and damage fruit.

As hailstones get larger, their energy and force when they strike objects increases dramatically. Baseball-sized hail falling from the sky has as much kinetic energy as a typical major league fastball. As a result, property damage, such as to roofs, siding, windows, and cars, increases as hail gets larger than the size of a quarter.

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A federal court in New York handed President Donald Trump a big setback Wednesday, blocking his audacious plan to impose massive taxes on imports from almost every country in the world.

A three-judge panel of the U.S. Court of International Trade ruled that Trump overstepped his authority when he invoked the 1977 International Emergency Economic Powers Act to declare a national emergency and justify the sweeping tariffs.

The tariffs overturned decades of U.S. trade policy, disrupted global commerce, rattled financial markets, and raised the risk of higher prices and recession in the United States and around the world.

The U.S. Court of International Trade has jurisdiction over civil cases involving trade. Its decisions can be appealed to the U.S. Court of Appeals for the Federal Circuit in Washington and ultimately to the Supreme Court, where the legal challenges to Trump’ tariffs are widely expected to end up.

Which tariffs did the court block?

The court’s decision blocks the tariffs Trump slapped last month on almost all U.S. trading partners and levies he imposed before that on China, Mexico, and Canada.

On April 2, Trump imposed so-called reciprocal tariffs of up to 50% on countries with which the United States runs a trade deficit and 10% baseline tariffs on almost everybody else. He later suspended the reciprocal tariffs for 90 days to give countries time to agree to reduce barriers to U.S. exports. But he kept the baseline tariffs in place. Claiming extraordinary power to act without congressional approval, he justified the taxes under IEEPA by declaring the United States’ longstanding trade deficits “a national emergency.”

In February, he’d invoked the law to impose tariffs on Canada, Mexico and China, saying that the illegal flow of immigrants and drugs across the U.S. border amounted to a national emergency and that the three countries needed to do more to stop it.

The U.S. Constitution gives Congress the power to set taxes, including tariffs. But lawmakers have gradually let presidents assume more power over tariffs, and Trump has made the most of it.

The tariffs are being challenged in at least seven lawsuits. In the ruling Wednesday, the trade court combined two of the cases — one brought by five small businesses and another by 12 U.S. states.

The ruling does leave in place other Trump tariffs, including those on foreign steel, aluminum, and autos. But those levies were invoked under a different law that required a Commerce Department investigation and could not be imposed at the president’s own discretion.

Why did the court rule against the president?

The administration had argued that courts had approved then-President Richard Nixon’s emergency use of tariffs in a 1971 economic and financial crisis that arose when the United States suddenly devalued the dollar by ending a policy that linked the U.S. currency to the price of gold. The Nixon administration successfully cited its authority under the 1917 Trading With Enemy Act, which preceded and supplied some of the legal language later used in IEPPA.

The court disagreed, deciding that Trump’s sweeping tariffs exceeded his authority to regulate imports under IEEPA. It also said the tariffs did nothing to deal with problems they were supposed to address. In their case, the states noted that America’s trade deficits hardly amount of a sudden emergency. The United States has racked them up for 49 straight years in good times and bad.

So where does this leave Trump’s trade agenda?

Wendy Cutler, a former U.S. trade official who is now vice president at the Asia Society Policy Institute, says the court’s decision “throws the president’s trade policy into turmoil.”

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President Donald Trump speaks during a swearing-in ceremony for interim U.S. Attorney General for the District of Columbia Jeanine Pirro, Wednesday, May 28, 2025, in Washington. (AP Photo/Evan Vucci)

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CLIMATEWIRE | Public officials have started pleading with the Trump administration for help in recovering from deadly disasters as President Donald Trump triggers frustration in states struck by tornadoes, floods, and storms by taking no action on requests for aid.

Trump has left states, counties and tribes in limbo as he delays making decisions on formal requests for millions of dollars in Federal Emergency Management Agency funding. Some areas that are still reeling from extreme weather are unable to start cleanup.

“We’re at a standstill and waiting on a declaration from FEMA,” said Royce McKee, emergency management director in Walthall County, Mississippi, which was hit by tornadoes in mid-March.

The county of 13,000 people can’t afford to clean up acres of debris, McKee said, and is waiting for Trump to act on a disaster request that was submitted by Gov. Tate Reeves, a Republican, on April 1 after the tornadoes killed seven people, destroyed or damaged 671 homes, and caused $18.2 million in public damage.

“I’m disappointed, especially for the people that lost their houses,” McKee said.

Trump himself assailed FEMA in January for being “very slow.”

The frustration over Trump’s handling of disasters is the latest upheaval

involving FEMA. Trump recently canceled two FEMA grant programs that gave states billions of dollars a year to pay for protective measures against disasters. The move drew protests from Republican and Democratic lawmakers.

On May 8, Trump fired FEMA leader Cameron Hamilton and replaced him with David Richardson, a former Marine Corps officer who has no experience in emergency management.

At a congressional hearing on Tuesday, Missouri Sen. Josh Hawley, a Republican, pleaded with Homeland Security Secretary Kristi Noem to push Trump to approve three disaster requests that Missouri Gov. Mike Kehoe, a Republican, had sent to Trump beginning April 2.

“We are desperate for assistance in Missouri,” Hawley said as Noem pledged to help. Her department oversees FEMA.

St. Louis Mayor Cara Spencer, whose city was badly damaged by tornadoes earlier this week, told MSNBC: “What we need right now is federal assistance. This is where FEMA and the federal government have got to come in and help communities. Our city can’t shoulder this alone.”

Trump has not acted on 17 disaster requests, a high number for this time of year, according to a FEMA daily report released Wednesday. On the same date eight years ago, during Trump’s first presidency, only three disaster requests were awaiting presidential action, the FEMA report from May 21, 2017, shows.

Eleven of the 17 pending disaster requests were sent to Trump more than a month ago.

“This looks to me like, until FEMA’s role is clarified, then we’re just going to sit on it,” said a former senior FEMA official who was granted anonymity to speak candidly.

Trump has indicated that he wants to shrink the agency, which distributes about $45 billion in disaster aid a year, helps with as many as 100 disasters at a time and, he said, “has been a very big disappointment.”

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As a parent, it may feel like managing your child’s sleep habits is an uphill battle—the busy swirl of school, extra-curricular activities, and the family circus can make getting to bed a chore. But sleep is not just important for physical health—it is essential for mental health, too. Getting to bed on time can be a challenge for busy families, but it’s possible to build a good rest routine to support children’s emotional and cognitive resilience.

Clinical psychologist Brian Razzino, Ph.D., stresses the importance of sleep as the “foundation” of mental health. “Think of sleep as the foundation of a house—if it’s shaky, everything built on it becomes unstable,” he says. “Chronic sleep deprivation undermines our emotional ‘blueprints,’ making us more prone to mood swings, heightened stress responses, and persistent anxiety.”

Dr. Razzino describes an emotional blueprint as the underlying structure or framework that shapes how a person experiences, processes, and expresses emotions.

The Link Between Sleep and Mental Health

When sleep is inadequate over long periods, it can significantly impact mood regulation, emotional stability, and mental health. Research highlights a direct link between chronic sleep deprivation and mental health disorders such as anxiety and depression. In a 2020 review in the National Library of Medicine, researchers found that individuals suffering from chronic insomnia were more likely to develop mood disorders. This reinforces the understanding that poor sleep is not just a symptom, but a contributing factor to mental health challenges.

Dr. Razzino says that “over time, insufficient sleep is strongly linked to a higher risk of clinical depression and more severe anxiety disorders,” and the effects are not limited to adults. Children and adolescents with disrupted sleep patterns are also at greater risk for mental health struggles. A 2024 study by renowned sleep researcher Evelyn Touchette and colleagues revealed that kids experiencing sleep difficulties, such as trouble falling asleep, were at an elevated risk for depression, ADHD, and conduct problems by age 15.

Dr. Razzino compares a child’s brain to a cluttered office by day’s end, with sleep serving as the cleaning crew that clears out waste and reorganizes for a fresh start the next day.

“Sleep acts as the brain’s overnight maintenance crew,” Dr. Razzino explains. “During sleep, our minds consolidate memories, process stressors, and strengthen the neural connections critical for learning. But when sleep is interrupted, these repair cycles are shortened, leading to deficits in emotional regulation and cognitive performance.”

While the link between sleep and emotional well-being is undeniable, emotional regulation and emotional resilience often become key areas of concern in children and adolescents facing sleep disturbances. From a clinical standpoint, understanding how sleep deprivation affects emotional responses is crucial, and learning how to implement age-appropriate support strategies can help mitigate these effects.

Emotional Resilience

Stephanie Drew, LCSW, a therapist specializing in child and adolescent mental health, also emphasizes the benefits of adequate sleep for emotional resilience. “Well-rested children are better equipped to regulate their emotions and cope with stress effectively,” she says. “Sleep helps develop emotional regulation skills, which are essential for coping with life’s challenges.”

For children, sleep disruptions—such as long sleep latency (difficulty falling asleep)—can be particularly detrimental. “Even one aspect of sleep disruption can gradually undermine the brain’s nightly ‘maintenance,’ leading to challenges in managing everyday stress, learning effectively, and developing stable emotional patterns,” Dr. Razzino adds.

Sleep-Deprived Parents Suffer, Too

Sleep deprivation doesn’t only affect children; it also has serious repercussions for adult mental health. Rebekka Wall, a certified adolescent and adult sleep consultant, explains, “Chronic lack of sleep affects our mental health because it increases stress, impairs our emotional regulation, and reduces our overall resilience to mental, emotional, and physical challenges.” Though parents may be able to push through sleep deprivation, adults, like children, need quality sleep to maintain their mental well-being, and going without rest can lead to a similar cascade of negative effects.

“When we lack sleep, we experience irritability, brain fog, and the parts of the brain that help us manage emotions don’t function as they should,” says Wall. “This results in an inability to cope effectively with stress, increased anxiety, and even symptoms of depression.” While addressing sleep and emotional regulation in children is crucial, it’s important to recognize the immense challenge parents face in ensuring everyone gets adequate rest, particularly when caring for younger children.

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Nearly 900 tornadoes have torn through more than 30 states so far this year, killing dozens of people, shredding buildings and landscapes across big chunks of the Eastern U.S., and costing billions. The oddly fickle and precise mix of atmospheric ingredients needed to generate tornadoes just happens to have occurred over and over again since mid-March, and the season isn’t over yet.

How do tornadoes form?

“In order to get a tornado, you need to have a thunderstorm that’s capable of producing a tornado,” says Jana Houser, a tornado researcher at the Ohio State University. Most often, these are what meteorologists call “supercell” thunderstorms, which feature a circulation pattern called a mesocyclone.

Supercell formation requires a set of conditions that make the atmosphere unstable, and these start with warm, moist air at the surface and cold, dry air above. The instability comes from warmer air’s greater buoyancy, which makes it rise upward. And this mix needs yet another specific ingredient, wind shear, “where winds change speed and direction as you go up with height” in the atmosphere, Houser says. This can create sort of a “tube” of horizontally rotating air. Next, the nascent twister needs an updraft, or upward-moving air, which tightens and speeds up the rotating air, taking it “from spinning like a bike tire” to “spinning like a top.”

All of these conditions are necessary, but they’re still not always enough. “Most supercells don’t even actually produce tornadoes in their lifetime,” Houser says.

The exact mechanics of tornado formation aren’t yet fully understood, but essentially, air rotation at the ground needs to meet a strong updraft aloft; this pulls the rotation in like a figure skater pulling in their arms, as Houser puts it.

Where do tornadoes form?

Tornadoes can—and do—happen wherever the right conditions are present, from Argentina to Italy to Bangladesh. But the U.S. is by far the leader in the average annual number of these storms. North America’s geography naturally promotes a crucial collision of air masses: juicy air streams northward from the bathtub warmth of the Gulf of Mexico, while cool, dry winds rush eastward over the Rockies. The air masses meet over the center of the country, which is how the region centered around northeastern Texas and Oklahoma came to be called Tornado Alley. “If you were to design a place that would get repeated severe storms, you would build something like the central U.S.,” says Rich Thompson, chief of forecast operations for the National Weather Service’s Storm Prediction Center.

But over the past decade or so, that tornado bull’s-eye has changed a bit. A “new Tornado Alley” has emerged about 400 or 500 miles to the east, in part because moist Gulf air is reaching farther east than in the past.

Why do tornadoes mainly form in spring?

“Spring tends to be the peak because it’s a transitional season,” Houser says. Coming out of winter, there is still abundant cold air at northern latitudes and aloft, and at the same time, the sun is shining much more, heating up the surface air to promote instability.

Fall is also a transitional season, but the air aloft remains generally warmer for some time after summer. Tornado activity doesn’t tend to pick up again until later in the fall, when the atmosphere has cooled down again.

The local peaks in tornado occurrence tend to move northward as spring rolls into the summer: the Gulf Coast peaks earlier in the spring, the Southern Plains in May and June, and the Northern Plains and upper Midwest in June and July.

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“The rivers have reversed and the tide has turned entirely against him,” he continued, citing a recent Axios Harris poll that showed Tesla had plummeted from eighth place in the ranking of America’s 100 most visible companies in 2021 to 95th in 2025.

Galloway attributed Tesla’s issues to Musk alienating the company’s core customer base with his turn toward politics over the last year.

In the United States, the Tesla CEO spent millions backing Trump’s presidential campaign and was almost inseparable from him during the transition. He then became the public face of DOGE, an advisory body tasked with reducing government spending.

While Musk became a hero to many of Trump’s supporters, the image of a tech billionaire wielding so much power also sparked a backlash, which mostly targeted Tesla.

Tesla reported a 71% drop in earnings per share year over year during its earnings call in late April and has faced widespread protests at its dealerships and showrooms.

“He is a brilliant guy, but he’s alienated his core demographic,” Galloway said on Friday. “He’s alienated the wrong people. Three-quarters of Republicans would never consider buying an EV. So he’s cozied up to the people who aren’t interested in EVs.”

During Tesla’s recent earnings call, Musk said he planned to step back from his work with DOGE and refocus on the companies that made him a household name. He reiterated that on Saturday.

“Back to spending 24/7 at work and sleeping in conference/server/factory rooms,” Musk wrote on X after the platform had battled with widespread outages.

“I must be super focused on 𝕏/xAI and Tesla (plus Starship launch next week), as we have critical technologies rolling out.”

The SpaceX CEO also told an audience at the Qatar Economic Forum on Tuesday that he planned to spend “a lot less” on political campaigns in the future.

“If I see a reason to do political spending in the future, I will do it,” Musk clarified. “I do not currently see a reason.”

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Elon Musk says he is stepping back from his government work to refocus on his companies.  Scott Olson/Getty Images

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Republicans in Congress intend to cut about US$880 billion in federal health care spending.

One of their primary targets is Medicaid. That government program covers 82 million Americans with health insurance. Most of the people enrolled in the program are low income, have disabilities, or both.

Medicaid, jointly funded by the federal government and the states, is also the biggest funder in the U.S. of long-term care services, whether they are delivered in the patient’s home, another location where they spend part of their day, or a nursing home. That makes it particularly important for older adults and those with disabilities. All states must meet the basic federal guidelinesfor Medicaid coverage. But 41 states have opted to take advantage of the Affordable Care Act provision that expanded eligibility to cover more people under the program.

We are gerontology researchers who study health and financial well-being in later life. We’ve been analyzing what the potential impacts of Medicaid cuts might be.

While the debate about how to reduce the budget focuses largely on dollars and cents, we believe that cutting federal spending on Medicaid would harm the health and well-being of millions of Americans by reducing their access to care. In our view, it’s also likely that any savings achieved in the short term would be smaller than the long-term increase in health care costs born by the federal government, the states and patients, including for many Americans who are 65 and older.

Weak track record

Wary of backlash from their constituents, Republicans have agreed on a strategy that would largely cut Medicaid spending in a roundabout way.

Previous efforts by the GOP in some states, such as imposing work requirements for some people to get Medicaid benefits, have not greatly reduced costs. That’s largely because there are relatively few people enrolled in the Medicaid program who are physically able to be employed and aren’t already in the workforce. Nor have past efforts to reduce fraud, waste, and abuse led to significant savings.

According to widespread media reports, Republicans are considering changes that would cut the amount of money that the federal government reimburses states for what they spend on Medicaid.

In May 2025, the nonpartisan Congressional Budget Office estimated that 8.6 million Americans would lose their health insurance coverage should the GOP proposal become law.

Historically, states have dealt with budget cuts by reducing their payments to health care providers, limiting eligibility, or restricting benefits. These reductions all particularly affected home- and community-based services that many disabled and older adults rely on.

About 3 in 4 of the people with Medicaid coverage who receive long-term care through the program get that care at home, in their communities, or both, rather than residing in a nursing home. States save an estimated 26 cents for every dollar spent on those services delivered outside nursing homes.

Losing coverage can be harmful for your health

We recently analyzed data from a nationally representative study of approximately 6,000 people who had Medicaid coverage but lost it when they turned age 65 because their income exceeded 100% of the federal poverty level. In 2025, that cutoff is about $15,560 for a single person and $21,150 for a couple.

Medicaid income eligibility generally drops from 138% to 100% of the federal poverty level at age 65 once Medicare becomes a person’s primary health insurer.

The people who participated in the study had lost their Medicaid coverage upon turning 65 between 1998 and 2020. Our team followed the experiences of these participants over a 10-year period starting at age 65 to see how they fared compared with people who continue to be enrolled in Medicaid after their 65th birthday.

What we found was both surprising and disturbing.

Fewer activities of daily living

Over the decade following that milestone, the people who lost their Medicaid coverage had more chronic conditions and could perform fewer activities of daily living, such as bathing and getting dressed, without any assistance as compared with those who still had Medicaid coverage. In addition, they were twice as likely to experience depression and be in fair or poor health.

As people’s health worsened, they also went to the hospital more often and stayed there longer. They also used outpatient surgery services more frequently.

These services are particularly expensive for the health care system. Depending on the service, it may also be costly for patients. Unlike the comprehensive coverage of Medicaid, the Medicare program fully covers only inpatient hospitalizations, short-term nursing facility care, hospice, some short-term home care, annual wellness visits, vaccines and some basic preventive care. Beyond that, Medicare requires the payment of premiums to help with uncovered services that can also include deductibles and copays.

This arrangement can lead to significant out-of-pocket costs that make health care hard for low-income older adults to afford unless they have both Medicare and Medicaid coverage.

We also found that older people who lost Medicaid coverage were less likely to see their primary care physician for routine and follow-up care, despite being enrolled in Medicare. This explains in part why they are going to the hospital more often, likely avoiding routine health care that may incur out-of-pocket costs and eventually utilizing Medicare-covered hospital care when needed.

In short, we found that exiting the Medicaid program upon turning 65 actually leads to an increase in the use of some of the most expensive health care services, such as inpatient hospitalization and outpatient surgery. So although Medicaid may no longer pay for these costs, the rest of the health care system does.

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