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Live Updates: Israel and Hamas Reach Deal on Hostage and Prisoner Exchange

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7 hours ago

David E. SangerEphrat Livni and Aaron Boxerman

Here’s the latest.

After months of deadlock, Israel and Hamas have reached an agreement for the release of Israeli hostages in exchange for Palestinian prisoners, a long-awaited breakthrough that could point toward an end to the two-year war in Gaza.

President Trump, who helped broker the deal, announced on social media Wednesday that both sides had agreed to the first phase of his plan, including that Israel would pull back their troops to an agreed upon line. Qatar, one of the countries helping negotiate, and Hamas also indicated in statements that the deal would allow for the entry of aid into Gaza.

Isabel Kershner

7 hours ago

Isabel Kershner

Netanyahu described the agreement as “a critical turning point,” as well as “a diplomatic success and a national and moral victory” for Israel, in a new statement. He also thanked President Trump for “his unwavering commitment to the safety of Israel and the freedom of our hostages.”

Isabel Kershner

7 hours ago

Isabel Kershner

Prime Minister Benjamin Netanyahu of Israel has spoken with President Trump and thanked him for his efforts and his “world leadership,” according to a statement from Netanyahu’s office. “The two held a very emotional and warm conversation and congratulated each other on the historic achievement,” the statement said. Netanyahu has invited the U.S. president to address the Israeli Parliament, the statement added.

Yara Bayoumy

7 hours ago

Yara Bayoumy

The hostage release is expected as soon as this weekend and preparations are already underway, an official familiar with details of the deal said.

Pranav Baskar

8 hours ago

Pranav Baskar

The Hostages and Missing Families Forum said in statement pos

ted to X on Wednesday the agreement had provoked “a mix of excitement, anticipation, and concern” among its members. The group expressed “profound gratitude” to President Trump, and called on the Israeli government to “convene immediately” to approve the agreement. “Any delay could exact a heavy toll on the hostages and soldiers,” the group wrote.

Isabel Kershner

8 hours ago

Isabel Kershner

It is nearly 3 a.m. in Israel and all the main television channels here are broadcasting live, though they usually shut down for the night around midnight. Tearful relatives of hostages and former hostages were posting emotional and joyful videos on social media. “That’s it, it’s over!” Meirav Gilboa-Dalal, the mother of hostage Guy Gilboa Dallal, 24, told Channel 12 News as family members cheered in the background.

Farnaz Fassihi

8 hours ago

Farnaz Fassihi

Iran had said earlier this week in a statement from its foreign ministry that it would support any decision made by Palestinians and their “resistance groups” as they negotiated with Israel on a Trump cease-fire plan. Iran has for years armed and funded Hamas as part of a regional policy that boosted regional militant groups known as the “axis of resistance’ to fight Israel. In the past two years, Israel has decimated groups like Hezbollah in Lebanon. Now if a cease-fire holds in Gaza, and Hamas disarms or retreats, it would deliver yet another blow to Iran’s regional strategy.

 

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https://static01.nyt.com/images/2025/10/08/multimedia/08israel-hamas-ceasefire-header2/08israel-hamas-ceasefire-hp-promo1-pctg-superJumbo.jpg?quality=75&auto=webpKatya Emelianova kneels beside a portrait of a loved one at a memorial to victims, soldiers, and hostages in Tel Aviv, Israel, Tuesday.Credit…David Guttenfelder/The New York Times

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Click the link below for the complete article:

https://www.nytimes.com/live/2025/10/08/world/israel-hamas-gaza-ceasefire

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A Composer’s ‘Brain’ Makes Music Years after His Death

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Rachel Feltman: For Scientific American’s Science Quickly, I’m Rachel Feltman.

Plenty of us would find it difficult to compose a new piece of music under any circumstances, even in the prime of our lives. But experimental composer Alvin Lucier is making music from beyond the grave—at least in a manner of speaking.

In a museum in Australia, a recent exhibition allowed visitors to hear sounds generated by neurons grown using the late artist’s blood. The exhibit raised questions about both consciousness and creativity and teased at what becomes possible when art meets cutting-edge neuroscience.

Here to tell us more about this musically prolific petri dish is Scientific American associate editor Allison Parshall.

Allison, so great to have you back with us.

Allison Parshall: Thank you for having me.

Feltman: So what are we gonna talk about today?

Parshall: Today, we’re going to talk about some experimental music. What do you know about experimental music? What do you think of when you think about it?

Feltman: I definitely think of John Cage first. I’m probably—I, I wouldn’t say I’m an experimental-music fan, but between having a sister who’s an opera singer and having done a little bit of modern dance in college with a teacher who loved Merce Cunningham, I guess [laughs] I probably know a little bit more than average. But yeah, I feel like John Cage is, like, the guy.

Parshall: Tell me a little bit about what you think about with John Cage.

Feltman: I mean, it’s hard not to think of 4’33” first, his piece that is simply the ambient silence of a room with an orchestra in it not playing.

Parshall: Peak experimental.

Feltman: Yeah, peak experimental. And also I feel like there’s been some great discourse and argument over, like, what constitutes a valid performance of 4’33” [laughs] and, like, what pollutes it. The sound of somebody texting—is that an okay thing to have [laughs] in a performance of 4’33”? That’s what comes to mind, for sure.

Parshall: So, like, the most experimental you can get: There is no music, or is that music …

Feltman: Right, yeah.

Parshall: Even if there is nothing? Yeah, I definitely think about 4’33”, also, the most, and he premiered that in 1952. And it was around that era that some experimental musicians were starting to probe into, like, the very nature of sound itself and what counts as music. And there was this one composer—not John Cage—whose work was so methodical it was almost scientific. He actually used his brain to make music back in the 1960s, and I have been utterly fascinated by this story for the past few months, so I’m very excited to get to tell you about it.

Feltman: I’m excited to hear about it.

Parshall: So let me set the scene for you: In Perth, Australia, there’s an art museum with a haunting musical exhibit. You start at the mouth of this dark, narrow hallway. It curves in front of you, getting wider as it goes, like the cochlea structure in your inner ear. The hallway is lined with these square-shaped brass plates that periodically vibrate with sound. The sound is a little bit different in every place that you stand in the room because the sound waves are coming from the plates and interacting with each other differently throughout the space.

No moment is the same as the last, and sitting at the center of the room is a brass plinth under a spotlight. At the top of the plinth, there’s a clear window, and you walk over, and you look down, and you see a small dish with a blob that’s just a few millimeters across.

These are brain cells, and they come from the legendary experimental composer Alvin Lucier. He’s dead; he passed away in 2021. But you’re surrounded by music that originates from this little organlike structure. It’s called an organoid.

The process of making this started with Alvin’s own blood cells, which were transformed into stem cells, which were then turned into neuronal cells like those in the brain. Those brain cells fire, sending electrical impulses that cause hammers behind each of the brass plates to strike. Microphones then pick up that sound—and any sound that you might be making while you’re in the exhibit—and feed that information as electrical signals back into Alvin’s brain organoid.

This exhibit is called Revivification for what it attempts to do: revivify Alvin—or at least some part of him.

Feltman: Wow, that’s very weird and kind of spooky, and I feel like probably has led to a lot of debate over how it fits into his portfolio as an experimental composer. I guess the first piece of information to know to get into that debate is: Did he know this was gonna happen? Did he plan for this? Did he …

Parshall: Yeah.

Feltman: Compose the situation?

Parshall: He was super aware that this was happening. In fact, it was his idea, or at least in part his idea, according to his collaborators on the project.

So I spoke with the other artists and the neuroscientists who were involved in the exhibit, as well as one of Alvin’s former colleagues. I also spoke with his daughter, Amanda Lucier; she’s a photojournalist based in Portland. And here’s what she had to say on the subject.

Amanda Lucier: There was something about the way that he was that made him think and made you think that he was never gonna die. That makes me smile, thinking about how he pulled off continuing to work and continuing to be a part of the world of experimental music quite literally after his death. I mean, if anyone was gonna pull off immortality, it was him.

Parshall: The story of Revivification, in many ways, actually starts a whole century ago with the invention of the EEG, or the electroencephalogram.

Feltman: I had one of those once. It was kind of anticlimactic because the process of preparing for it is so dramatic: you get the cap with all the electrodes, and they, like, use this weird paste to stick it to your head. Then the actual test is just you kind of sitting there existing while a computer does something that you can’t see—though I do remember that the goop does stay in your hair, so that’s a fun thing that happens [laughs].

Parshall: I imagine that’s no fun to wash out, but I’ve never had one before. But they seem kind of cool, if you said anticlimactic.

An EEG, what it does is measures the electrical activity from the brain from outside the skull, and it’s using, like you mentioned, those electrodes that are placed all over the head. And what it’s so good at is capturing real-time information from the brain. So it can capture waves of activity as networks of neurons fire in concert with one another. Those waves of activity, they travel at different speeds. So gamma waves are the fastest. They happen when you’re really focused or thinking about something. Delta are the slowest, and those happen when you’re in, like, a dreamless sleep. And alpha waves, they happen when you’re in a relaxed but awake state, like during meditation.

So when EEG was first invented, roughly a hundred years ago, it allowed for the very first recordings of the live human brain, like, living brain activity. And so, of course, neuroscientists were all over it as a tool for unpacking what is actually going on in the brain as we do different activities. Before, they just kinda had to wait for you to die, and then look what it looked like.

In the 1960s, it caught the attention of Alvin, who was then a composer on the faculty at Brandeis University. He was feeling uninspired in his work at the time, but he was totally taken by this technology.

Alpha brain waves are too low in frequency to be heard by the human ear. We can hear down to, like, 20 hertz, or 20 waves per second. And these waves, alpha brain waves, are generally, like, 10 hertz. But Alvin’s colleagues wanted him to record the waves and then manipulate them into something that humans could hear and then use that audio to create a composition. But he was not interested in that at all. What he wanted to do was far more interesting and experimental.

Parshall: He developed a piece called “Music for Solo Performer.” Alvin would sit in a chair with EEG electrodes on, in front of an audience, and try to meditate. If he was successful, the low-frequency alpha brain waves would be picked up by the electrodes, amplified and then played through speakers that are positioned throughout the room. The waves would still be inaudible, but directly in front of the speakers would be percussion instruments—such as gongs and cymbals, bass drums, timpanis—and the sound waves would cause them to vibrate along with the speakers, producing audible noise that the audience could hear.

There was something really scientific about the way that Alvin approached composition. Here’s Susan Leigh Foster. She’s a close colleague and friend of Alvin and his family. A dance professor for years, she taught with Alvin at Wesleyan University, where he spent most of his career.

Susan Leigh Foster: This would be maybe the most important thing I could say about Alvin [laughs]: he liked setting up conditions, or forces, that would then produce sound. In that way, he really bears a lot of similarity to the way that scientific work is done. Like, you have a hypothesis. You set up the experiment. You conduct the experiment.

You know, what if you take a sound and send it down a long wire and then amplify that and then watch as it changes over the hours as the room temperature keeps changing and as people come into the room and as air currents change, or what if you bury speakers underground, which is a project he did at Dartmouth.

Parshall: Alvin was always listening and observing. Here’s his daughter again.

Lucier: I remember being mortified as a middle-school student going into a Pier 1 Imports with some friends, and there was a vacuum going, and he would match the tone of the vacuum to see if he could create beading patterns. So he’d be in the corner there, going, like: [hums note]. And now, in retrospect, I think, “Oh, wow, that was really cool for me to have that experience.” And at the time, I was like, “Oh, my God, Dad, even in the Pier 1 Imports.” [Laughs.]

Parshall: Over the course of his career, Alvin became a well-known and respected experimental composer. Guy Ben-Ary, one of the artists responsible for Revivification, admired him greatly.

Guy Ben-Ary: I mean, Alvin was one of the greatest composers of the 20th century. He was not part of kind of popular culture and not part of the group of classical composers that, you know, [were] very famous. They say that he was the composer’s composer.

Parshall: When Guy first encountered Alvin’s work in the late 2000s, it inspired him to bring sound into his artwork. So then he embarked on creating what he called a sort of unconventional, quote, “self-portrait.”

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https://static.scientificamerican.com/dam/m/62f6d95d708bc7d4/original/2509_SQ_FRI_BRAIN_MUSIC-1-1.jpeg?m=1758895018.361&w=900Jack Mitchell/Getty Images; Illustration by Scientific American

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Click the link below for the complete article (sound on for Podcast):

https://www.scientificamerican.com/podcast/episode/neuroscience-and-art-collide-in-a-posthumous-composition-by-alvin-lucier-in/?_gl=1*114pifr*_up*MQ..*_ga*MjAxNDU1MDc4OS4xNzU5OTEyNzM1*_ga_0P6ZGEWQVE*czE3NTk5MTI3MzQkbzEkZzAkdDE3NTk5MTI3MzQkajYwJGwwJGgw

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4 Reasons This Government Shutdown Is Different

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The House hasn’t been seen in weeks. The Senate is at a standstill. Bipartisan negotiations are nonexistent. And the White House seems more interested in making punitive threats against its own federal workforce than in trying to get them back to work.

This is the bleak state of Republican-controlled government under President Donald Trump on the eighth day of a government shutdown that has disrupted federal services, left thousands of federal employees on furlough, and caused ground stops at some airports due to shortages of air traffic controllers. The deepening impasse has many lawmakers in a pessimistic mood, raising fears of a protracted and painful battle that could go on for several more weeks.

“The first couple of days I was pretty sanguine about prospects of coming out of it, but it’s just gotten worse and worse and worse, and I think we’re going to be dug in for a while,” Sen. John Kennedy (R-La.) told HuffPost when asked about the state of play on Capitol Hill.

What makes this standoff over spending different from previous shutdowns — in 2019, 2018, and 2013 — is how dug in both parties are to their respective positions, how little urgency there is to reach a compromise, and how angry Democrats are about Trump’s abuse of executive powers to rescind or withhold money approved by Congress.

Democrats Are Fed Up

In March, Senate Minority Leader Chuck Schumer (D-N.Y.) faced widespread intraparty backlash after he helped pass a Republican spending bill to avert a shutdown. Since then, the Trump administration has frozen billions of dollars in federal funding, shuttered several executive agencies, deployed military troops to major U.S. cities, weaponized the Justice Department against his critics, bullied law firms and universities, and launched a widespread national crackdown on undocumented immigrants.

Democrats are now demanding that, at the least, the Trump administration agree to stop freezing or rescinding more federal funds if they vote for a bill reopening the government. What reason, Democratic lawmakers ask, do they have to support a spending bill that in effect supports Trump’s lawlessness and puts no guardrails on the executive branch?

Moreover, Democrats want to address enhanced Affordable Care Act health insurance subsidies that are due to expire at the end of the year. If Congress doesn’t act, and soon, premiums will more than double on average for over 20 million people enrolled in the health care program. Four million people are estimated to lose their insurance entirely.

A recent poll found three-quarters of the public, including a majority of Trump’s MAGA supporters, say they want Congress to extend the subsidies, stiffening Democrats’ resolve this time around.

“We need to get serious about fixing the problems here at home, starting with health care,” Schumer said in a Senate floor speech on Tuesday. “And Democrats’ position has not changed: We want the same thing that a majority, an overwhelming majority, of Americans want, which is to end this shutdown and halt the health care crisis that will send premiums spiking for tens of millions of people.”

Republicans maintain there’s nothing to negotiate until Senate Democrats vote to reopen the government, accusing them of holding hostage government funding over unrelated policy demands — a tactic the GOP also employed in previous shutdown fights. They maintain that they are willing to discuss the enhanced ACA subsidies, which Democrats passed during the pandemic, but the issue has sharply divided GOP lawmakers in both the House and Senate, and it is unclear whether they’d be willing to take it up or pass a fix by the end of the year.

“The Democrats want to have a conversation about the COVID tax credit cliff that they created, and at some point we’re happy to have that conversation, but not until the government opens up,” Senate Majority Leader John Thune (R-S.D.) told reporters on Tuesday.

Negotiations? What Negotiations?

During previous shutdowns, the president of the United States — including Trump himself — hosted congressional leaders multiple times at the White House to discuss a way to reopen the government. Bipartisan Senate groups took matters into their own hands to help move things along, holding private talks that eventually yielded a compromise.

This time around, Trump convened one meeting with all four congressional leaders at the White House, but he didn’t do so until the eve of the funding deadline of Sept. 30. It went nowhere.

n the Senate, meanwhile, there’s been no formation of a group or committee tasked with coming up with a deal. Rank-and-file members have instead held informal discussions on the floor that have made little progress. The House isn’t even in session at all and isn’t expected to return until Tuesday — three weeks after it last held votes.

“There is, you know, conglomerations of different people and groups, but it’s been very informal,” said Sen. Richard Blumenthal (D-Conn.). “The basic dichotomy here is [Speaker Mike] Johnson and Trump and [Senate GOP leader John] Thune won’t give us a vote before the shutdown is ended. It’s hard to negotiate when Johnson isn’t even having his members come back before Oct. 14.”

“They simply will not talk, which seems different from past years,” he added. “We want to sit down with Trump. We want to sit down with Johnson. They’re basically saying, vote for the bill, and then we’ll talk.”

A big reason lawmakers have struggled to reach a deal is the deep lack of trust in Washington in recent years. The Trump administration has repeatedly ripped up prior bipartisan spending agreements, controversial moves that have poisoned the well with Democrats and made it harder for them to accept a short-term funding bill, as even some Republicans have acknowledged.

“There has to be enough trust that a deal can be made,” Sen. Bill Cassidy (R-La.) told HuffPost.

He then pondered, hopefully: “Is there some condition that can be achieved, that you can have a trustless society in the sense where we can still go forward, but not necessarily trust each other?”

‘Intimidation Tactics’

In an effort to cow Democrats into submission, the White House Office of Management and Budget has threatened several punitive measures against its own government, including enacting mass firings of furloughed employees and suggesting that those on furlough won’t necessarily get paid back when the government eventually reopens.

This isn’t what happened under Trump’s first presidency after the government shut down in 2019, the longest shutdown in history, when he demanded Democrats agree to fund construction of his border wall. Trump actually signed a bill into law codifying what had been a bipartisan tradition of authorizing back pay for furloughed federal workers after government shutdowns.

But the White House threats backfired on Capitol Hill as Democrats vowed to stand firm in their demands, and even some Republican lawmakers voiced their disagreement.

“These intimidation tactics are making it clear that they are not acting in any good faith,” Sen. Chris Murphy (D-Conn.) said. “So for people who think you’re going to cut a deal with these guys and they’re going to live up to the deal, they’re showing you every single day that they’re only interested in dirty politics.”

Sen. Jeanne Shaheen (D-N.H.), a retiring moderate Democrat who has been involved in bipartisan discussions about a deal to reopen the government and address the expiring health care insurance subsidies, was even more blunt about OMB Director Russ Vought.

“It would be a lot easier to resolve the situation if Russ Vought would stop talking,” she told HuffPost.

It wasn’t just Democrats crying foul, either. Sen. Thom Tillis (R-N.C.) called the threats from the White House “bad strategy.”

“I think that if you’re talking about my staff and other staff, that’s probably not a good message to send right now to people who are not being paid,” Tillis told reporters. “I’m not an attorney, but I think it’s bad strategy to even say that sort of stuff.”

Trump’s Muddled Messaging

Prior government shutdowns garnered much more national attention than the current standoff. Part of this is because shutdowns and drama over government funding used to be rare in Washington. Nowadays, the institution is consumed with political gridlock, and it seems like the lawmakers are constantly dealing with threats of shutdown. Often, the most they can do is kick the can down the road by passing a “continuing resolution” to keep funding going at current spending levels.

n the last few weeks, however, Trump has been anything but focused on the government funding fight playing out in Washington. He’s been far more busy drawing all sorts of headlines on other fronts, including making attacks against late night TV show hosts and other nations at the United Nations General Assembly, announcing new domestic policies, launching strikes against suspected Venezuelan drug cartels, sending National Guard troops into Illinois and Oregon despite opposition from those states’ governors, and calling for Chicago’s mayor and the governor of Illinois to be jailed. On Wednesday, he’s set to hold a roundtable on antifa, a loose movement opposed to fascism.When he has addressed the situation on Capitol Hill, he has often contradicted GOP leadership, undercutting their positions by saying he is open and willing to speak to Democrats and that he’d like to pay furloughed federal workers.

Polls show most Americans don’t expect to be personally affected by the shutdown. Only 11% said they expected to be personally affected, according to a YouGov survey conducted last week. That could change as the pain of a government shutdown becomes more acute and more people are affected by airport staffing shortages. Federal workers will also begin missing paychecks on Oct. 10, and military families on Oct. 15. During the 2019 shutdown, the Pentagon was one of the few departments that was funded, which is one of the reasons it lasted so long.

“It’s a factor,” Sen. Tim Kaine (D-Va.) said of the coming soft deadlines. “I mean, we don’t like any of this. We just want them to fix the problem that they made, that’s going to cause Virginians to have to pay so much more for health care or lose health insurance. So that’s what we’re focused on.”

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https://img.huffingtonpost.com/asset/68e65cac1800000c625d1a13.jpeg?ops=scalefit_720_noupscale&format=webp

Senate Minority Leader Chuck Schumer attends a news conference following a weekly Democratic policy luncheon Tuesday on Capitol Hill.  Andrew Harnik via Getty Images

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Click the link below for the complete article:

https://www.huffpost.com/entry/government-shutdown-trump-chuck-schumer_n_68e65a73e4b0d98d3e52f5e4

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Joan Kennedy, Who Married Into a Dynasty, Dies at 89

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Joan Kennedy, who married into one of America’s foremost political dynasties and spent much of her life wrestling with alcoholism while caught up in the tragedies and tempests that plagued the Kennedy family, died on Wednesday at her home in Boston. She was 89.

Her death was confirmed by Steve Kerrigan, the chairman of the Massachusetts Democratic Party. He did not cite a cause, saying only that she had died in her sleep.

The former wife of Senator Edward M. Kennedy, known as Ted, Ms. Kennedy was shy and reserved compared with her competitive, athletic, and often boisterous in-laws. Ill-prepared for life in the reflected glare of Kennedy klieg lights, and haunted by her own family history of alcoholism, she found herself caught up in high-stakes politics, a faithless marriage, and an on-again, off-again struggle with her own drinking.

For stretches at a time, however, she registered numerous triumphs. An accomplished pianist, she gave a recital with the Philadelphia Orchestra in 1970 that won standing ovations and stellar reviews. Under the baton of Arthur Fiedler, she narrated stories, like Prokofiev’s “Peter and the Wolf,” accompanied by the Boston Pops. She published a book, “The Joy of Classical Music: A Guide for You and Your Family” (1992), edited by her sister-in-law, Jacqueline Kennedy Onassis. And she devoted her later years to raising money for nonprofit organizations and charities in Boston.

But she was never interested in politics, the Kennedy family business. Her introduction to it came when her husband campaigned for and won a special election to the Senate in 1962, when he was just 30 and she was 27. By then, his brother John was president, and his brother Robert was attorney general.

Within a few years, though, with the assassinations of John and Robert, pressure built on Senator Kennedy to take up their mantle despite his family’s concern for his safety. He became less discreet about his infidelities and excessive drinking, and Joan, too, turned increasingly to alcohol.

She stood by her husband through considerable drama, most notably in 1969, when he drove off a one-lane bridge on Chappaquiddick Island, in Massachusetts, in an accident that killed his passenger, Mary Jo Kopechne, a 28-year-old former secretary to Robert F. Kennedy when he was a senator from New York.

Ms. Kennedy, who was pregnant at the time, had already endured two miscarriages and was on strict bed rest. With the Chappaquiddick drama threatening her husband’s political future, she accompanied him to Ms. Kopechne’s funeral and to court, where he pleaded guilty to leaving the scene of an accident.

Shortly afterward, she miscarried again. By then, she said, she had begun drinking heavily as the family rallied around Senator Kennedy.

“For a few months, everyone had to put on this show, and then I just didn’t care anymore,” Ms. Kennedy told Laurence Leamer, the author of “The Kennedy Women” (1994). “That’s when I truly became an alcoholic.”

Her drinking eventually became public, with repeated arrests on charges of drunken driving, starting in 1974, and orders to enter rehabilitation programs.

She and Mr. Kennedy had effectively separated before he ran for president unsuccessfully in 1980, but they kept up a united front during his campaign for the Democratic nomination; after he dropped out, the marriage officially dissolved.

Virginia Joan Bennett was born on Sept. 2, 1936, in New York City. She and her younger sister, Candace, were raised in upper-middle-class suburban Bronxville, N.Y., by their mother, Virginia Joan (Stead) Bennett, an amateur seamstress who made most of their clothes, and their father, Harry Wiggin Bennett Jr., an advertising executive whose ancestors had arrived in Massachusetts in the 1600s.

Joan was studious and loved playing the piano. While a student at Manhattanville College of the Sacred Heart (now Manhattanville University) in Purchase, N.Y., where she majored in English and minored in music, she worked part-time as a model and competed in beauty contests. She appeared in television commercials for Maxwell House coffee and in print ads for beauty products. She was also the Revlon Hairspray girl, appearing live on the game show “The $64,000 Question.”

She made her debut in New York society twice, first at the fifth annual Gotham Ball, then at the 19th Debutante Cotillion and Christmas Ball.

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https://static01.nyt.com/images/2025/10/09/multimedia/00kennedy_joan-pzgh-print1/00kennedy_joan-pzgh-superJumbo.jpg?quality=75&auto=webpJoan Kennedy, with her husband at the time, Edward M. Kennedy, in Boston in 1979, when he announced his campaign for the 1980 Democratic presidential nomination. Their children, Kara Ann and Patrick, joined them for the event.  Credit…George Tames/The New York Times

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Click the link below for the complete article:

https://www.nytimes.com/2025/10/08/us/joan-kennedy-dead.html?smid=nytcore-android-share

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Health Care Politics Bolster Democrats in Shutdown Fight

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When the top two Democrats in Congress sat down with President Trump in the Oval Office last week a day before the government was to shut down, they warned him that the coming fight was going to be politically painful for him and his party.

If Republicans failed to agree to extend expiring Obamacare subsidies, as Democrats were demanding as a condition of any government funding deal, Mr. Trump and the G.O.P. would bear the brunt of the blowback from voters, Senator Chuck Schumer and Representative Hakeem Jeffries, the two minority leaders from New York, told the president.

Prices would spike for around 20 million Americans, they explained, including for many Trump voters.

Mr. Trump did not dispute the point, saying that Mr. Schumer and Mr. Jeffries were probably right, according to three people briefed on the private conversation who spoke on the condition of anonymity to describe it. But he quickly added that he and Republicans would deflect blame back onto Democrats.

A White House official said that Mr. Trump had disputed the argument by responding that everyone would make their own case to the public as to who was at fault.

The exchange helps explain why Democrats believe they have the political upper hand in the shutdown fight, and why they are refusing to back down from their demands, at least for now. They believe that Mr. Trump, who has long been sensitive to the political perils of health care issues for Republicans, could be the key to winning a commitment on the expiring subsidies that could end the crisis.

Democrats are keenly aware that Republicans in Congress are divided on extending the subsidies, with some of them, including those from competitive states and districts, sounding the alarm about the coming premium increases.

“I made the point that the damage that’s being done to the health care of everyday Americans is hurting people who voted for him, and that is the reality,” Mr. Jeffries recently told reporters as he described the case he had made to Mr. Trump in the Oval Office that day. “It’s hurting everybody, but it’s certainly hurting people who voted for him.”

Data backs up his point. According to KFF, a health policy research group, more than half of all people receiving insurance through the Affordable Care Act live in congressional districts represented by Republicans, with particularly high concentrations in southern states such as Florida, Georgia, Mississippi, and South Carolina, all of which have not expanded Medicaid under the 2010 law.

And Mr. Trump’s longtime pollster, John McLaughlin, warned this summer in an op-ed that circulated widely among Republicans in Washington that a potential tax hike on more than 24 million working-class Americans could spell “potential political catastrophe for the G.O.P.”

Still, despite Mr. Trump’s professed openness to a deal, and that of some rank-and-file Republicans, there is little appetite among G.O.P. leaders to extend the Affordable Care Act tax credits, which Democrats enacted in 2021 during the coronavirus pandemic as a temporary measure to allow more Americans to obtain health coverage.

Speaker Mike Johnson and Senator John Thune, the South Dakota Republican and majority leader, have both said that significant changes would need to be made to how they are distributed before any extension could be brought to the floor.

It is possible that the renewed subsidies could be approved in the House and Senate by Democrats and a minority of Republicans, but that is a scenario that both leaders would be eager to avoid.

The Republican leaders have also insisted that they would not negotiate with Democrats until they vote to reopen government, creating the stubborn impasse. Democrats say they need a commitment on health care well beyond a promise of future negotiations, and they say Republicans have so far offered nothing close to that in informal discussions, let alone any formal talks.

With Republicans on Capitol Hill resisting, Democrats see Mr. Trump and his natural inclination to cut a deal as providing a potential off-ramp as the shutdown drags on.

“I’d like to see a deal made for great health care,” Mr. Trump told reporters at the White House on Monday. “I’m a Republican, but I want to see health care much more so than the Democrats.”

The remarks made Republicans on Capitol Hill nervous, and Mr. Trump quickly walked them back on Tuesday after speaking with Mr. Johnson.

“I think Schumer is incapable of making a deal,” Mr. Trump said. “They are a mess. They’re a party that has no leadership — and they have no policy.”

But Democrats are mostly holding firm, a sign of confidence that they are on the right side of the shutdown politics. As of Tuesday, not a single additional Democrat had crossed over to support Republicans’ stopgap bill to reopen the government, aside from the three aligned with Democrats who did so last week.

Republicans had built their strategy for resolving the shutdown around the idea that they could break off anxious Democrats as the closure took a toll on federal services, and eventually push the spending bill through to passage.

Instead, Senator Angus King of Maine, an independent who caucuses with Democrats and broke ranks last week to back the G.O.P. bill, openly mused on Monday about withdrawing that support.

“The best they’ve been able to tell us so far is that they’re open to conversations about solving the A.C.A. problem,” Mr. King said of Republicans. “That doesn’t cut it.”

Mr. Thune on Tuesday said that Senate Democrats were being “bludgeoned” by the left to hold the line, and that he still held out hope that more would join Republicans.

“They’re under enormous pressure from their leadership, but there are going to have to be some brave souls who are courageous enough to come out and deliver the votes to open up the government,” he said.

In the House, Representative Marjorie Taylor Greene, the far-right Republican from Georgia, chimed in with an improbable plug for Democrats’ position, saying that while she opposed the Affordable Care Act, she had learned that her “own adult children’s insurance premiums for 2026 are going to DOUBLE” if Congress failed to act.

But even Republicans who would back an extension of the subsidies say that they would only consider talks once the government is reopened.

Senator Susan Collins, Republican of Maine and the chairwoman of the Appropriations Committee, said she had been privately circulating her own multipart proposal for ending the shutdown, but that negotiations centered on the Obamacare subsidies could begin only after the government were reopened.

“There would be a commitment to having that discussion,” she said of the A.C.A. subsidy extension.

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Senator Chuck Schumer of New York, the minority leader, with other Democratic senators at the Capitol on Tuesday. Credit…Tierney L. Cross/The New York Times

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Good Conversations Don’t Require Everybody to Agree, Neuroscience Shows

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With each turn of the news cycle, you may wonder how anyone in their right mind, seeing what they’re seeing, could still hold differing political views from your own. I wrestle with some of these feelings myself. When I talk with people on the other side of a debate, I’m often tempted to push them to see things how I do. Or I may stay close to issues where I know we agree, so we can have a conversation that feels safe and easy.

But there is a third option for navigating these conversations: curious exploration. My and my colleagues’ research into the ways brain activity across people aligns or diverges as they converse suggests that seeking to persuade may not be the most fruitful way to approach a conversation. Instead, an open attitude, allowing ourselves to traverse a range of ideas and to learn from other people’s experiences, may be both more enjoyable and productive.

In recent years, neuroscientists have identified an important phenomenon: brain synchrony, in which brain activation in two or more people increases and decreases in similar regions at similar times. When people’s brain activity is in sync, it seems to indicate a common interpretation and understanding of what they are experiencing. For example, when one person tells a story, and another understands it in the same way, the listener’s brain aligns with the speaker’s and even begins to anticipate what will come next. On the other hand, when people interpret the same story in markedly different ways, perhaps because they’ve been given different background information, their brain activity is less synchronized than people who are given the same background facts and therefore share the same assumptions coming in.

These insights apply not only to hearing stories or watching movies but also to responding to news media and political content. Strong political speeches can bring people’s brains into sync with one another, for instance. But people get their news from politically polarized sources, which means that they encounter news coverage of different events and receive diverging analyses of the same events. This shapes their views of those issues and creates conflicting background assumptions when they encounter new political stories. In parallel, studies show divergence in brain responses when people with different political views engage with the news, as though they were making sense of different stories altogether. In research initiated by the late Emile Bruneau at the University of Pennsylvania, who died in 2020, and carried forward by Nir Jacoby, now at Dartmouth College, our team scanned the brains of participants who identified as Democrats or Republicans while they watched video clips of people talking about policies. We found that participants’ brain activation in social and emotional processing systems was more aligned with people from their own party than it was with those from the opposing party.

All of this work hints that our interactions might be more harmonious if we were more in sync with one another. But evidence from a new technique called functional magnetic resonance imaging (fMRI) hyperscanning, which can track brain activity during real conversations, complicates that idea. This method is exciting because it allows researchers to observe two brains in action at the same time. With hyperscanning, we can see how people’s brains respond to one another during real-time conversation. My collaborators and I have been using it to understand the dynamics of good conversations—exchanges where people enjoy themselves, reach consensus on how to solve hard problems or help each other navigate emotional challenges. We’ve discovered that even if one’s goal is to simply enjoy the conversation, sticking to safe topics where everyone is on the same page might not be the best solution. In a hyperscanning study, our team, including psychologists Lily Tsoi of Caldwell University, Shannon Burns of Pomona College, Sebastian Speer, and Diana Tamir, both at Princeton University, gave friends and strangers instructions to get to know each other better. We found that the conversations participants enjoyed the most were not those where their brain activity stayed perfectly in sync the whole time.

Strangers, on average, gradually increased their neural synchrony over the course of a conversation, whereas friends typically started out more in sync with one another early on. Then something interesting happened: after starting off more in sync, friends’ patterns of brain activity in regions that process social interactions began to diverge. They covered more topics and explored wider ground than strangers and, on average, enjoyed the conversations more. Strangers explored fewer topics and had less enjoyable conversations. But some pairs of strangers showed a pattern more like friends. These pairs seemed to use synchrony as a jumping-off point for exploring more ideas rather than an end. In turn, these pairs of strangers, whose brain activity diverged as the discussion unfolded, also rated their conversations as more enjoyable.

And in conversations where people needed to discuss their differences of opinion, we encountered a similarly intriguing finding. In still unpublished work, our team studied what happened as people discussed policy issues, such as the future of higher education and environmental concerns. We coached these participants to enter these conversations in one of two ways: with a goal to compromise or a goal to persuade. When people came into the conversation looking to compromise, we found, this led to more expansive exploration (for example, covering more topics, mental states, and brain patterns). Ultimately, this more expansive exploration led to greater consensus about how to solve large societal problems. On the other hand, the people who came in trying to persuade their partner explored less in their conversations and were ultimately less successful in achieving a shared vision for a path forward.

Recently, I tried to put these findings into practice while speaking with a colleague who held different views than I did and learned how events that had unfolded in his job and community had shaped his opinions and decisions. Although the conversation was tiring and did not end in complete agreement, it renewed our connection to each other and left me open to talking more.

To be sure, individual conversations in isolation can’t fix society’s polarization. Institutions—including media, industry, and government—play a major role in shaping culture, assumptions, and divides. Still, these institutions are also composed of people, and conversations are a key tool for reimagining the world we want together. Our findings suggest one set of possibilities for people navigating conversations with those across divides. We can be more open, curious, and exploratory when speaking with others, rather than avoid controversies or start off pushing our viewpoint.

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Kaptnali/Getty Images

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How to Kill Mosquitoes: What Works and What Doesn’t

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Mosquitoes bite, suck your blood, and leave you with itchy bumps and possibly a horrible infection. Mosquito-borne pathogens include malaria, West Nile virus, Zika virus, Chikungunya virus, and dengue. No wonder so many of us want to learn how to kill mosquitoes for good.

While you might fantasize about living in a mosquito-free world, eradicating them would actually be disastrous for the environment. Adult mosquitoes are food for other insects, birds, and bats, while larval mosquitoes support aquatic ecosystems. The best we can hope for is to limit their ability to transmit disease, repel them, and kill them within the confines of our yards and homes.

Mosquito-killing products bring in the big bucks, so it should come as no surprise that there is a wealth of misinformation out there. Before you get sucked into buying a product that simply won’t work, get educated about what does and does not kill these blood-sucking pests.

Key Takeaways: How to Kill Mosquitoes

  • The best way to kill and control mosquitoes is to consistently apply more than one method. Some methods may only target adults, while others may only target larvae.
  • Effective ways to kill mosquitoes include removing breeding grounds, encouraging predators, applying an agent containing BTI or IGR, and using traps.
  • Insect repellents and bug zappers don’t kill mosquitoes.
  • Pesticide-resistant mosquitoes may survive spraying, plus the chemical kills other animals and may persist in the environment.

How Not to Kill Mosquitoes

First things first when learning how to kill mosquitoes: You need to understand the difference between repelling them and killing them. Repellents make a location (like your yard or skin) less attractive to mosquitoes, but don’t kill them. So, citronella, DEET, smoke, lemon eucalyptus, lavender, and tea tree oil might keep the insects at bay, but won’t control them or get rid of them in the long run. Repellents vary in effectiveness, too. For example, while citronella may deter mosquitoes from entering a small, enclosed area, it doesn’t really work in a wide-open space (like your backyard).

There are a host of methods that actually do kill mosquitoes, but aren’t great solutions. A classic example is a bug zapper, which kills only a few mosquitoes, yet attracts and kills beneficial insects that keep the mozzy population down. Similarly, spraying pesticides is not an ideal solution because mosquitoes can become resistant to them, other animals get poisoned, and the toxins can cause lasting environmental damage.

Source Reduction

Many species of mosquitoes required standing water to breed, so one of the most effective methods of controlling them is to remove open containers and repair leaks. Dumping containers of standing water kills the larvae living in them before they get a chance to mature.

However, removing water may be undesirable or impractical in some cases. Further, some species don’t even need standing water to reproduce! The Aedes species, responsible for transmitting Zika and dengue, lays eggs out of water. These eggs remain viable for months, ready to hatch when sufficient water becomes available.

 

Biological Methods

A better solution is to introduce predators that eat immature or adult mosquitoes or infectious agents that harm mosquitoes without affecting other wildlife.

Most ornamental fish consume mosquito larvae, including koi and minnows. Lizards, geckos, dragonfly adults and naiads, frogs, bats, spiders, and crustaceans all eat mosquitoes.

Adult mosquitoes are susceptible to infection by the fungi Metarhizium anisoplilae and Beauveria bassiana. A more practical infectious agent is the spores of the soil bacterium Bacillus thurigiensis israelensis (BTI),. Infection with BTI makes the larvae unable to eat, causing them to die. BTI pellets are readily available at home and gardening stores, easy to use (simply add them to standing water), and only affect mosquitoes, black flies, and fungus gnats. The treated water remains safe for pets and wild animals to drink. The disadvantages of BTI are that it requires reapplication every week or two and it doesn’t kill adult mosquitoes.

Chemical and Physical Methods

There are several chemical methods that target mosquitoes without the risks to other animals that come with spraying pesticides.

Some methods rely on chemical attractants to lure mosquitoes to their doom. Mosquitoes are attracted to carbon dioxide, sugary scents, heat, lactic acid, and octenal. Gravid females (those carrying eggs) may be attracted to traps laced with a hormone released during the egg-laying process.

The lethal ovitrap is dark, water-filled container, typically with a small opening to prevent larger animals from drinking the water. Some traps use chemicals to bait the traps, while others simply provide a convenient breeding ground. The traps may be filled with predators (e.g., fish) or with dilute pesticide to kill larvae (larvicide) and sometimes adults. These traps are highly effective and affordable. The disadvantage is that multiple traps must be used to cover an area (about one every 25 feet).

Another chemical method is the use of an insect growth regulator (IGR), added to water to inhibit larval development. The most common IGR is methoprene, which is supplied as a time-release brick. While effective, methoprene has been shown to be mildly toxic to other animals. 

Adding a layer of oil or kerosene to water kills mosquito larvae and also prevents females from depositing eggs. The layer alters the surface tension of the water. Larvae can’t get their breathing tube to the surface for air, so they suffocate. However, this method kills other animals in the water and makes the water unfit for consumption.

Physical Methods

You don’t have to be an expert to know how to kill mosquitoes with this method. One example of a physical method of killing mosquitoes is swatting them with your hand, a fly swatter, or an electric swatter. Swatting works if you’ve only got a few mosquitoes, but it’s not particularly helpful if you’re being swarmed. While bug zappers aren’t ideal outdoors because they can unnecessarily kill beneficial insects, electrocuting indoor insects isn’t generally considered objectionable. Just remember, you need to bait a bug zapper to attract mosquitoes because they don’t care about the pretty blue light.

Because mosquitoes are not strong fliers, it’s also easy to suck them onto a screen or into a separate trap using a fan. Mosquitoes caught using a fan die from dehydration. Screen traps may be made at home by fastening window screening fabric over the back of a fan.

The Bottom Line

If you’re serious about killing mosquitoes, you’ll probably need to use a combination of methods to control them. Some of the most effective strategies target either the larvae or the adult. Others kill mosquitoes at all stages of their life cycle, but may miss some of the insects.

If you live in a wetland area and get a significant influx of mosquitoes from outside your property, you won’t be able to kill all of the local population. Don’t despair! Scientists are developing ways to make mosquitoes sterile or lay eggs that won’t mature. In the meantime, you’ll need to combine repellents with lethal measures to enjoy the outdoors.

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https://www.thoughtco.com/thmb/YJ-Z-ZfdwudoPH8jpcgOXa1A4vQ=/750x0/filters:no_upscale():max_bytes(150000):strip_icc()/dead-mosquito---2-157293242-5a9edac0fa6bcc0037220151.jpgMost people believe the only good mosquito is a dead mosquito. doug4537 / Getty Images

https://www.thoughtco.com/thmb/OWo6fLVA8x7n91BzAXHATqnVbCU=/750x0/filters:no_upscale():max_bytes(150000):strip_icc()/tombstone-drawn-by-dead-mosquito-489008121-5a9fe6986bf0690036c5dce9.jpgYou may need to use a combination of methods to kill mosquitoes. Stefano Petreni / EyeEm / Getty Images

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Gaza Peace Talks Take Place Just Ahead of 2nd Anniversary of Oct. 7

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As Israel prepared to mourn on the second anniversary of the Oct. 7 Hamas-led attack, talks to end the devastating war in Gaza were expected to continue on Tuesday in Egypt, with the focus on a hostages-for-prisoners swap proposed by the Trump administration.

The grim anniversary falls on Sukkot, a Jewish harvest festival. Most businesses across Israel will be closed for the holiday, and the government has delayed formal commemorations until later this month. As a consequence, the mood is expected to be subdued.

Some relatives of hostages gathered outside Prime Minister Benjamin Netanyahu’s residence on Monday night to hold a holiday prayer service and to call for an end to the conflict.

Einav Zangkauer, whose son Matan is a captive in Gaza, addressed President Trump in a video from the event. “Please end this nightmare,” she said. “Please make it happen.”

She was referring to a plan to end the war and bring home the hostages that President Trump unveiled last month, being discussed in Egypt this week. And Ms. Zangkauer was expressing a sentiment shared by many.

“Everyone wants it to happen,” President Trump said on Monday evening at a briefing in the White House, speaking of his peace proposal. “Even Hamas.”

But much still remains unresolved.

The indirect talks between Israel and Hamas, mediated by the United States, Qatar, and Egypt, are likely to focus on two aspects of Mr. Trump’s 20-point proposal: exchanging Israeli-held Palestinians for captives, and an Israeli pullback from parts of Gaza.

Israel believes that about 20 hostages are still alive in Gaza, and also seeks the remains of about 25 others. Secretary of State Marco Rubio told Fox News Sunday that Hamas had “agreed to the president’s hostage release framework.”

Under that plan, the hostages will be exchanged for 250 Palestinians prisoners serving life sentences and 1,700 Gazans jailed by Israel during the war. For every hostage whose remains are released, Israel will also release the remains of 15 Gazans.

While the plan calls for the release of the hostages within 72 hours of Israel agreeing to it, that would be logistically difficult, experts say. And the two sides have yet to agree on which Palestinian prisoners will be released.

The White House press secretary, Karoline Leavitt, told reporters at a briefing on Monday that the teams were in Egypt to discuss that exchange. “They’re going over the list of both the Israeli hostages and also the political prisoners who will be released, and those talks are underway,” she said.

“All sides of this conflict agree that this war needs to end,” she said, “and agree to the 20-point framework that President Trump proposed.” The talks, she added, were an “incredible achievement.”

On Friday, Hamas said it was willing to release the hostages. But Hamas has not addressed major points in the American peace plan, among them demands that it has objected to in the past. The proposal, for example, calls on the group to disarm and for it to have no role in the governance of Gaza — both key Israeli positions that Hamas has long rejected.

Questions also remain about the withdrawal of Israeli forces from positions in Gaza.

In a social media post on Saturday, Mr. Trump said that Israel had already agreed to an initial withdrawal line within Gaza for the first phase of the deal.

“When Hamas confirms, the Ceasefire will be IMMEDIATELY effective, the Hostages and Prisoner Exchange will begin, and we will create the conditions for the next phase of withdrawal,” he pledged.

But Hamas may still seek to negotiate those lines.

In previous talks on ending the conflict, Hamas agreed to Israeli troops withdrawing into a buffer zone near Gaza’s border with Israel. But Mr. Trump’s plan would leave Israeli forces deeper in Gaza, and Hamas has signaled that it may object to elements of the plan.

In a speech to Israelis over the weekend, Prime Minister Benjamin Netanyahu tried to cast the Trump plan as a victory. He said the stage for a possible deal to end to the war had been set by his decision to keep up the pressure on Hamas with a devastating military campaign, which drew condemnation from much of the world. He also cited diplomatic efforts.

Members of Mr. Netanyahu’s far-right coalition have long objected to a deal and have threatened to dissolve his government if he agrees to one. The prime minister has sought to appease them, but he is also under pressure from many Israelis who want a hostage deal and an end to the conflict, as well as from the international community, not least Mr. Trump.

On Saturday, Mr. Trump posted images of Israelis rallying in Tel Aviv for a hostage deal. He added no comments, but the images appeared to speak for themselves.

Defying Mr. Trump does not appear to be an option, even for Mr. Netanyahu. By Saturday, the Israeli military was limiting its actions to what Israeli officials called defensive operations and responses to immediate threats.

Hamas, too, is under pressure to end the war.

Many Palestinians in Gaza see the Trump proposal as their best hope after nearly two years of extreme privation and repeated displacement. Much of Gaza has been destroyed, tens of thousands of Palestinians have been killed, including thousands of children, and Mr. Trump has said that Israel will have a green light to destroy Hamas if the group does not agree to a deal.

Mr. Trump demanded on social media that Israel stop bombing Gaza to allow the agreement with Hamas to move forward. The Israeli military instructed its forces to focus on defense, curbing military operations in the Gaza Strip, according to Israeli officials.

The fighting on the ground has nonetheless continued. The Israeli military said that it launched multiple attacks on Sunday against what it described as militants threatening troops. Emergency workers in Gaza said that they had been unable to reach some of those killed because they were in combat zones.

Israel and Hamas have held indirect talks off and on throughout the war, with negotiations generally falling apart. Mr. Rubio conceded on Sunday that the war was not yet over and that there was work to be done, but he said this time could be different.

“What gives you hope here is that at least there is now a framework for how all this can come to an end,” he said.

Ms. Leavitt on Monday declined to give a deadline for the discussions but said “the Administration is working very hard to move the ball forward as quickly as we can.”

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https://www.nytimes.com/2025/10/06/world/middleeast/israel-gaza-hamas-peace-talks.html

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NIH Funds New Autism Studies on Genes and Environment as Trump Focuses on Tylenol

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Scientists moved a step closer to understanding the complex causes of autism this week. Although all of the headlines went to US President Donald Trump’s poorly evidenced statements that the painkiller acetaminophen is linked to the neurodevelopmental condition, his White House autism event brought welcome — and largely overlooked — news to scientists: the US National Institutes of Health (NIH) is investing US$50 million in an unusual autism-research effort.

Trump and Jayanta Bhattacharya, director of the NIH, announced on 22 September that 13 research groups will receive funding under the Autism Data Science Initiative (ADSI), a Trump administration programme to fund studies that explore how interacting genetic and environmental factors contribute to autism. “This is where the field needs to be going in searching for the complex causes of autism,” says Helen Tager-Flusberg, who studies autism at Boston University, Massachusetts.

The funded projects range from studies on environmental exposures during pregnancy to experiments on brain cells. Funding was also awarded to efforts to replicate the projects’ results and so ensure that they are robust.

Researchers, although pleased by the aims of the funded work and the rigour of the methods, have some concerns about the project. Several ADSI-funding recipients say that they are expected to complete their projects relatively quickly — within three years instead of the usual five — and some say that they are alert to political interference with their results. Trump prompted fierce pushback from scientists with his statements about acetaminophen earlier this week, given the lack of convincing evidence to support a link with autism. “We should wait until the research happens before announcing an answer,” says Jason Stein, a neuroscientist at the University of North Carolina, Chapel Hill, who received an ADSI grant.

“This is not political interference, but rather a bold, science-driven effort to deliver meaningful answers more quickly,” said a spokesperson for the US Department of Health and Human Services (HSS), which oversees the NIH.

Quick turnaround

The NIH announced the ADSI in May and invited researchers to submit grant applications for research into the causes of autism, its growing prevalence, and potential interventions. Some researchers expressed concern that applicants had only a month to submit proposals — much less time than usual — and it was unclear who was reviewing the grants and with what criteria. Some worried that the funding would be channelled to researching the discredited idea promoted by Trump’s health secretary, Robert F. Kennedy Jr, that vaccines are linked to autism. “Some people thought: maybe we should steer clear of this,” says Judith Miller, a psychologist who studies autism at the Children’s Hospital of Philadelphia in Pennsylvania.

In the end, nearly 250 research teams applied, and no awards were granted to projects that focus explictly on autism and vaccines.

Several of the projects will involve exposomics: the study of the array of environmental factors to which a person is exposed. Miller is leading a three-year, $4.3-million project combining genome and exposome data to seek factors associated with autism. The project will draw on previously collected data on more than 100,000 children, including about 4,000 autistic children, and connect those to maternal-health records. The research team plans to use information on where participants live to add in data on air quality, access to green spaces, and other environmental markers. “We haven’t been able to bring this type of data all together in a clinical population,” before, Miller says.

Replication requirement

Stein and his team, by contrast, are examining autism using brain organoids grown from the stem cells of autistic and non-autistic children. The researchers plan to expose the tissue to substances that epidemiological studies have linked to autism — such as valproic acid, a drug used to treat epilepsy — and examine how this affects gene activity.

The team expects to be asked by the NIH to look at acetaminophen or other substances, too, says Joseph Piven, a psychiatrist at University of North Carolina, Chapel Hill, who is also working on the organoid project. “As long as they have some detectable level of epidemiological evidence, I think that’s a valid question to go forward,” he says.

The ADSI is building in replication efforts from the start. Judy Zhong, a population-health scientist at Weill Cornell Medicine in New York City, has received around $5 million from the ADSI for a centre that will require other ADSI-funded investigators to hand over their computer models so that their results can be independently replicated. “It is very unusual,” Zhong says.

Collaborative approach

But researchers are still worried about political interference in autism research. Some point to the announcement earlier this month that the HHS would award a contract to Rensselaer Polytechnic Institute in Troy, New York, to search for an association between vaccines and autism in databases. “Is this the best use of funds to support another investigation, on what appears to be a largely settled question?” says Craig Newschaffer, an autism researcher at Pennsylvania State University in University Park.

Some researchers would like to see more funding for research that helps autistic people to lead healthy and fulfilling lives — a primary focus of only 2 of the 13 ADSI grants. Katharine Zuckerman, a paediatrician at Oregon Health & Science University in Portland, will be using her $4.25-million grant to look for factors in childrens’ lives — such as regular doctor’s visits or attending quality schools — that correlate with outcomes that autistic people say are important to them, such as sleep or good mental health. Like the other ADSI projects, this will be done in consultation with the autism community.

“Looking at the cause of autism is important, but I think that it’s also important that we address the concerns of autistic people who are here today and what we could do to improve their lives,” Zuckerman says.

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https://static.scientificamerican.com/dam/m/1774977d8a31ddb6/original/brain-organoid.jpg?m=1758909843.8&w=900

Confocal light micrograph of a synaptic conjugation between three-dimensional (3D) human embryonic stem cell (hESC)-derived brain organoids grown on an organ-on-chip (OOC) system. An OOC is a multi-channel 3D microfluidic cell culture. Organoids are miniature, simplified versions of organs grown in the laboratory. These organoids are being grown to study neural tube formation and neuronal development.  Arthur Chien/Science Source

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How Entrepreneurs Can Spot Opportunities in Unlikely Place

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Key Takeaways

  • Breakthrough ideas rarely follow a straightforward path. They often emerge from connecting unexpected skills and experiences.
  • If you’re looking to apply your skills and past knowledge to new frontiers, you should draw on your background, stay focused on the mission, and curate expertise early.

Most founder stories begin with a business plan, a pitch deck, or a stint in a Silicon Valley accelerator. Mine started in a garage, working as a mechanic before moving into large-scale solar construction. That unconventional path gave me a perspective I believe many entrepreneurs share: The best ideas rarely follow a straightforward path. They come from connecting unexpected skills and experiences. Whether you build in energy, finance or technology, the real opportunity lies in spotting links that others overlook.

As industries evolve, founders are increasingly asked to combine insights from different fields. The next breakthrough can come from anywhere. My story is one version of that pattern: years in construction, side ventures in cycling and crypto, as well as a growing conviction that blockchain and renewable energy could merge into something bigger. The important point is that these connections are available to anyone willing to look for them

NFTs beyond the hype

For me, the clearest connection between seemingly separate paths came in the form of NFTs. They showed how a digital tool could unlock real-world solutions when applied differently.

For many, NFTs are shorthand for speculation and hype. They recall headlines of digital art selling for millions during a bubble, but at their core, NFTs are simply verifiable certificates of ownership. They are secure, transparent and impossible to counterfeit. Those qualities give them value far beyond collectibles.

Renewable energy is a prime example. Historically, solar infrastructure has been locked behind institutional walls. You needed significant capital, specialized contracts, and relationships in a closed network. By linking NFTs to renewable projects, individuals could hold digital certificates that represent direct participation in the infrastructure powering their communities. Instead of being abstract shareholders in a utility, people could have verifiable claims tied to specific assets — be it a solar farm in Spain or a wind project in Japan.

This points to a broader principle for founders: Technologies often outgrow the reputations they start with. Something like NFTs, which were dismissed as frivolous in one context, can become transformative in another. The pattern is common. Artificial intelligence was once a niche academic field before becoming the backbone of entire industries. Cloud computing was once seen as insecure and unreliable, but today no modern business can operate without it. Hype cycles can distract, but they can also be early signals of where long-term value will emerge. Leaders must learn to separate noise from substance and recognize when a tool is finally ready for serious application.

Blockchain as an equalizer

Blockchain itself grew from speculation, but its biggest benefit lies in offering access. Traditional finance and infrastructure projects often operate like exclusive clubs, requiring large amounts of money, insider knowledge, and legal support. Blockchain lowers these barriers. It makes processes transparent, allows direct participation, and removes unnecessary intermediaries.

In renewable energy, that means individuals and small groups can help finance and accelerate the transition alongside corporations and governments. Participation is no longer limited to the few who already sit inside the system. That is the equalizing force blockchain brings — and it is the type of structural change founders should be looking for in their own industries.

Advice for founders

From my own journey, three lessons stand out for anyone looking to apply their expertise to new frontiers:

1. Draw on your background, however unconventional. Skills picked up in unrelated fields often prove essential later. Steve Jobs famously credited a college calligraphy class with shaping the typography of the Macintosh. In my case, running construction sites taught me how to manage risk, coordinate teams, and solve problems under pressure — skills that proved invaluable when I later moved into blockchain. Founders often underestimate their own experience, but the truth is that most breakthroughs are not born from a blank slate. They are built on layers of past knowledge, applied in new ways.

2. Stay focused on the mission. Every industry has hype cycles, but blockchain is especially noisy. New tokens, fads, and shortcuts appear daily. The temptation to chase quick wins is strong, but they rarely build lasting businesses. Innovation requires a clear mission and the patience to execute it. Founders who withstand the noise are those who anchor themselves to a long-term vision. That discipline not only creates stronger companies, but it also builds credibility with partners, regulators, and investors who are looking for stability in a volatile field.

3. Curate expertise early. Great founders are not experts in everything; they are curators of expertise. To bring my project to life, I brought in specialists from day one. Identifying gaps early and filling them before they become roadblocks is essential. It saves time, prevents costly mistakes, and accelerates execution. The best founders see themselves less as lone visionaries and more as architects — assembling the right team and letting them excel in their respective domains.

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Entrepreneur

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Click the link below for the complete article:

https://www.entrepreneur.com/growing-a-business/how-entrepreneurs-can-spot-opportunities-in-unlikely-places/497258

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