James' World 2

Click the link below the picture

.

Immune cells rush to the brain and promote deep sleep after a heart attack, according to a new study involving both mice and humans. This heavy slumber helps recovery by easing inflammation in the heart, the study found.

The findings, published on October 30 in Nature, could help to guide care for people after a heart attack, says co-author Cameron McAlpine at the Icahn School of Medicine at Mount Sinai in New York City, who studies immune function in the cardiovascular and nervous systems. “Getting sufficient sleep and rest after a heart attack is important for long-term healing of the heart,” he notes.

The implications of the study go beyond heart attack, says Rachel Rowe, a specialist in sleep and inflammation at the University of Colorado Boulder. “For any kind of injury, your body’s natural response would be to help you sleep so your body can heal,” she says.

The heart needs its sleep

Scientists have long known that sleep and cardiovascular health are linked. People who sleep poorly are at a higher risk of developing high blood pressure, for example, than are sound sleepers. But how cardiovascular disease affects sleep has been less explored.

To learn more, the authors induced heart attacks in mice and investigated the animals’ brainwaves. The researchers found that these mice spent much more time in slow-wave sleep — a stage of deep sleep that has been associated with healing — than did mice that hadn’t had a heart attack.

Next, the authors sought to understand what was causing that effect. One obvious place to look was the brain, which controls sleep, notes McAlpine. After a heart attack, immune cells trigger a massive burst of inflammation in the heart, he says, and the researchers wondered whether these immune changes also occurred in the brain.

The team found that, after a mouse’s heart attack, immune cells called monocytes flooded its brain. These cells produced large amounts of a protein called tumour necrosis factor (TNF), which is an important regulator of inflammation and also promotes sleep.

To confirm that these cells were linked to the increased sleep, researchers prevented monocytes from accumulating in the rodents’ brains. As a result, “the mice no longer had this increase in slow-wave sleep after their heart attack,” McAlpine says, supporting the theory that the influx of monocytes to the brain contributes to the post-heart-attack sleep boost. Similar experiments confirmed TNF’s role as a messenger to sleep-inducing brain cells.

.

.

.

Click the link below for the article:

.

__________________________________________