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A team of researchers from the US National Cancer Institute and the National Heart, Lung, and Blood Institute has developed an enhanced version of a cryo-electron microscope, meaning that these powerful tools for determining protein structures are more powerful than ever.
Cryo-electron microscopes (also known as cryo-EM) are used for analysis on the molecular or near-atomic level, and according to Science, the new one created by NCI structural biologist Dr. Sriram Subramaniam and his colleagues is the highest-resolution device of its kind to date.
The research team used their cryo-EM to create a new image that reveals a drug-like molecule bound to its protein at closer to atomic resolution than previously possible. The resolution is so sharp, the publication said, that it rivals the “gold standard” of mapping atomic protein contours, x-ray crystallography.
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